A5055905068- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Chronic Lymphocytic Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Chronic Myeloid Leukemia Treatments
- Laser Applications in Dentistry and Medicine
- Monoclonal and Polyclonal Antibodies Research
- Olfactory and Sensory Function Studies
- T-cell and Retrovirus Studies
- Diagnosis and Treatment of Venous Diseases
- Chemical Synthesis and Analysis
- Microplastics and Plastic Pollution
- Computational Drug Discovery Methods
- Infectious Aortic and Vascular Conditions
- HIV Research and Treatment
- Supramolecular Self-Assembly in Materials
- Essential Oils and Antimicrobial Activity
- Polyamine Metabolism and Applications
- Infective Endocarditis Diagnosis and Management
- Vascular Procedures and Complications
- Wound Healing and Treatments
- Click Chemistry and Applications
- Retinoids in leukemia and cellular processes
- Structural Analysis of Composite Materials
- Protein Degradation and Inhibitors
Medical University of Lodz
2017-2024
University of Łódź
2011-2016
Abstract Dendrimers are highly branched macromolecules with the potential to be used for biomedical applications. Several dendrimers toxic owing their positively charged surfaces. However, this toxicity can reduced by coating these peripheral cationic groups carbohydrate residues. In study, of three types 4th generation poly (propyleneimine) were investigated in vivo ; uncoated (PPI‐g4) dendrimers, and which 25% or 100% surface amino coated maltotriose (PPI‐g4‐25%m PPI‐g4‐100%m),...
Abstract Dendrimers provide many exciting opportunities for potential biomedical applications. However, owing to their positively charged surfaces, poly(propyleneimine) (PPI) dendrimers show toxic and haemolytic activities. One of the methods masking peripheral cationic groups is modify them using carbohydrate residues. In this study, three types fourth generation PPI dendrimers‐uncoated (PPI‐g4), approximately 35% maltotriose (Mal‐III)‐coated (PPI‐g4‐OS), 90% Mal‐III‐coated (PPI‐g4‐DS) were...
Oligosaccharide-modified poly(propylene imine) dendrimers are promising candidates as drug carriers and anti-prion agents. Here, we report the biodistribution of maltotriose-modified 4th generation (PPI) their ability to cross blood–brain–barrier that is important if these glycodendrimers considered potential therapeutic agents in central nervous system (CNS).
Dendrimers are highly branched macromolecules with the potential in biomedical applications. Due to positively charged surfaces, several dendrimers reveal toxicity. Coating peripheral cationic groups carbohydrate residues can reduce it. In this study, cytotoxicity and genotoxicity of three types 4th generation poly(propylene imine) were investigated. Peripheral blood mononuclear cells (PBMCs) treated uncoated (PPI-g4) dendrimers, which approximately 40% or 90% amino coated maltotriose...
Chronic lymphocytic leukemia (CLL) is the most common in Europe and North America. For many years scientists doctors have been working on introducing effective therapy into CLL as prognosis of survival time course disease differ among patients, which might pose a problem treating. Nanotechnology providing new insights diagnosis and, compared with conventional treatments, more efficient improve patients' comfort by decreasing side effects. Among various nanoparticles that are available,...
Although chronic lymphocytic leukemia (CLL) is the most common adult in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) an antitumor candidate cancer therapy. This study examines proapoptotic effects of poly(propylene imine) (PPI) glycodendrimers modified maltotriose residues (PPI‐G4‐OS‐Mal‐III and PPI‐G4‐DS‐Mal‐III) on TNF family CLL cells. The combination understanding signaling pathways...
We have investigated how low intensity laser irradiation emitted by a multiwave-locked system (MLS M1) affects the viability and proliferation of human bone marrow mesenchymal stem cells (MSCs) depending on parameters irradiation.Cells isolated surgically from femoral during surgery were identified flow cytometry cell differentiation assays. For irradiation, two wavelengths (808 905 nm) with following used: power density 195, 230, 318 mW/cm 2 , doses energy 3, 10, 20 J (energy 0.93-6.27 J/cm...
Published results of studies on poly(propylene imine) (PPI) dendrimers indicate their potential use in the treatment brain cancer or neurodegenerative diseases due to ability cross blood-brain barrier. However, depending dose, neurotoxicity may occur. Here, we discuss impact maltotriose modified PPI rat's nervous system. Wistar rats were treated intravenously for 14 consecutive days with densely (dense-shell; DS) and partly (open-shell; OS) at doses established as safe previous experiment...
Abstract The Wnt/β‐catenin signaling pathway is shown to play a significant role in the control of survival, proliferation, and differentiation hematopoietic cells. Studies have confirmed that aberrant activation canonical Wnt occurs various forms leukemia, crucial for chronic lymphocytic leukemia (CLL) pathogenesis. aim study evaluate influence maltotriose (M3) modified fourth generation poly(propylene imine) dendrimers (PPI‐G4) on gene expression CLL (MEC‐1) cells compare these findings...
Background: Chronic lymphocytic leukaemia (CLL) cells are characterized by failures in the apoptosis pathway and increased proliferation, resulting progressive accumulation of B-lymphocytes blood. Despite wide range antileukaemic drugs, CLL remains an incurable disease. However, a breakthrough is expected which will allow more effective treatment. </p> <p> Objective: The study investigates influence poly(propyleneimine) (PPI) dendrimer with peripheral amino groups, 30% were...
Background: Chronic Lymphocytic Leukaemia (CLL) is an indolent disorder, which mainly affects older adults. Since the advent of chemoimmunotherapy, great progress has been made in its treatment. However, some patients develop a more aggressive form disease and are included group high-risk CLL with dismal prognosis need for new therapies. Objective: Maltotriose-modified poly(propylene imine) dendrimers were presented as potential agents targeted therapy murine xenograft model. Methods:...
The development of molecular nanostructures with well-defined particle size and shape is eminent interest in biomedicine. Among many studied nanostructures, dendrimers represent the group those most thoroughly characterized ones. Due to their unique structure properties, are very attractive for medical pharmaceutical applications. Owing controllable cavities inside dendrimer, guest molecules may be encapsulated, highly reactive terminal groups susceptible further modifications, e.g.,...