A5036113696- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Antimicrobial agents and applications
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- HIV Research and Treatment
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Synthetic Organic Chemistry Methods
- Synthesis and characterization of novel inorganic/organometallic compounds
- Immunotherapy and Immune Responses
- Synthesis and properties of polymers
- HIV/AIDS drug development and treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Bacteriophages and microbial interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Virology and Viral Diseases
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
Universidad de Alcalá
2016-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Instituto Cajal
2019-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2018-2025
Centro de Investigación Biomédica en Red
2024
Instituto de Salud Carlos III
2008-2022
Bioengineering Center
2015-2021
Instituto de Química Orgánica General
2016-2020
Center for Innovation
2018-2019
University of Lisbon
2018-2019
Abstract Novel amine‐ or ammonium‐terminated carbosilane dendrimers of type n G‐[Si{OCH 2 (C 6 H 3 )‐3,5‐(OCH CH NMe ) }] x , G‐[Si{O(CH N(Me)(CH and G‐[Si{(CH NH + I − Cl have been synthesized characterized up to the third generation by two strategies: 1) alcoholysis SiCl bonds with amino alcohols subsequent quaternization MeI, 2) hydrosilylation allylamine SiH dendritic systems HCl. Quaternized are soluble in water, although degradation is apparent due hydrolysis SiO bonds. However,...
Cationic carbosilane dendrimers of generations 1–3 have been synthesized employing thiol–ene click chemistry. The obtained present three different types ammonium functions, two them with the charge at surface, –NH3+ and –NMe3+, other internalized by presence ethylalcohol moieties, –[NMe2(CH2CH2OH)]+. influence –NMe3+ –[NMe2(CH2CH2OH)]+ in dendrimer structure studied molecular dynamics. antibacterial properties these families evaluated against Gram-positive (Staphylococcus aureus CECT 240)...
Carbosilane-based ruthenium dendrimers have been tested as anticancer agents. These metallodendrimers are active against a number of cisplatin resistant cell lines in the low micromolar range while showing dendritic effect.
A series of carbosilane dendritic compounds Gn-ONNMem, containing one (n = 0), four 1), eight 2), or 16 3) terminal pyridylimine ligands, substituted with m methyl groups (m 0, 2, 3), and nickel complexes Gn-ONNMemNiBr2, comprising monometallic to metallodendritic structures, have been synthesized. The complexes, in combination methylaluminoxane (MAO), are active catalysts for the concurrent transformation ethylene into mixtures toluene-insoluble polyethylene oily oligomers. Oligomers...
The purpose of this research was to determine the potential use water-soluble anionic and cationic carbosilane dendrimers (generations 1–3) as mucoadhesive polymers in eyedrop formulations. Cationic decorated with ammonium –NH3+ groups were prepared by hydrosylilation Boc-protected allylamine followed deprotection HCl. Anionic terminal carboxylate also employed study. In vitro vivo tolerance studies performed human ocular epithelial cell lines rabbit eyes respectively. interaction...
The bactericidal activity of a library cationic dendritic systems depends on the hydrophilic/hydrophobic structural balance, being presence sulfur atom proximal to peripheral ammonium functions relevance.
The search for new microbicide compounds is of an urgent need, especially against difficult-to-eradicate biofilm-forming bacteria. One attractive option the application cationic multivalent dendrimers as antibacterials and also carriers active molecules. These require adequate hydrophilic/hydrophobic structural balance to maximize effect. Herein, we evaluated antimicrobial activity carbosilane (CBS) unmodified or modified with polyethylene glycol (PEG) units, planktonic P. aeruginosa...
One of the major limitations for treatment many diseases is an inability drugs to cross cell membrane barrier. Different kinds carriers are being investigated improve drug bioavailability. Among them, lipid or polymer-based systems special interest due their biocompatibility. In our study, we combined dendritic and liposomal analysed biochemical biophysical properties these formulations. Two preparation methods Liposomal Locked-in Dendrimers (LLDs) have been established compared. Carbosilane...
Abstract The use of dendrimers as drug and nucleic acid delivery systems requires knowledge their interactions with objects on way to the target. In present work, we investigated interaction a new class carbosilane functionalized polyphenolic caffeic residues human serum albumin, which is most abundant blood protein. addition albumin solution decreased zeta potential albumin/dendrimer complexes compared free increased density fibrillary form shifted fluorescence spectrum towards longer...
A new family of amine- and ammonium-terminated carbosilane dendrimers the type Gn-[Si(CH2)3N(Et)CH2CH2NMe2]x Gn-{[Si(CH2)3N+R(Et)CH2CH2N+RMe2]x(X−)y} (where n = 1, 2 3; R H, X Cl; Me, I) respectively has been synthesized by hydrosilylation N,N-dimethyl-N′-allyl-N′-ethyl-ethylenediamine, [(CH2CH–CH2)(Et)N(CH2)2NMe2] with corresponding hydride-terminated subsequent quaternization HCl or MeI. Quaternized are soluble stable in water other protic solvents for long time periods. The antibacterial...
Novel amine- and ammonium-terminated carbosilane dendrimers of type Gn-[Si{CH2O-(C6H4)-3-NMe2}]x or Gn-[Si{CH2O-(C6H4)-3-NMe3+I−}]x have been synthesized characterized up to second generation by phenolysis (chloromethyl)silyl-terminated with 3-dimethylamine phenol subsequent quaternization methyl iodide. Quaternized are stable in protic solvents can be solubilised water after the addition less than 1% dimethyl sulfoxide. A study antimicrobial activity these cationic first against both...