A5054682822- Helicobacter pylori-related gastroenterology studies
- Estrogen and related hormone effects
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Gastroesophageal reflux and treatments
- Microscopic Colitis
- Drug Transport and Resistance Mechanisms
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Esophageal Cancer Research and Treatment
- T-cell and B-cell Immunology
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Reproductive System and Pregnancy
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Neuropeptides and Animal Physiology
University of Łódź
2016-2025
University of Utah
2021-2024
Huntsman Cancer Institute
2021
New Mexico Cancer Center
2020
University of New Mexico
2020
UNM Comprehensive Cancer Center
2020
Institute of Molecular Medicine
2020
Medical University of Lodz
2015
Rigshospitalet
2015
Immunotherapy of gastrointestinal cancers is challenging; however, several lines evidence suggest that adoptive transfer stimulated or modified immune cells support not only protective role in tumor microenvironment, but actively participate the elimination cancer cells.In vivo studies employing cell-derived allograft murine models were performed. The effects T helper (Th) 2 on growth and microenvironment composition using Th2 cells, interleukin (IL)-5 treatment, immunofluorescence,...
The pathogenesis of inflammatory bowel diseases (IBD) seems to be associated with alterations immunoregulation. Several lines evidence suggest that estrogens play a role in the modulation immune responses and may related etiology IBD. purpose this work was examine involvement G protein-coupled estrogen receptor (GPER), α (ERα), β (ERβ) ERα spliced variants ERα36 ERα46 Crohn’s disease (CD) ulcerative colitis (UC). studied group included 73 patients IBD 31 sex age-related controls. No...
Background: Current treatment of gastroesophageal reflux disease (GERD) is focused on decreasing the gastric acid secretion. However, there still a group patients not responding to conventional therapy. Proteinase-activated receptors and purinergic have been involved in inflammation, visceral hyperalgesia, esophageal hypersensitivity. The aim this study was evaluate expression PAR2 (F2RL1) P2RX2, P2RX3 P2RY2 GERD patients. Methods: studied quantified using real-time PCR biopsies with healthy...
Abstract Background An accumulating data suggest that the adhesion G protein-coupled receptor F5 (ADGRF5) is fundamental for human health and diseases1-3. It was noted ADGRF5 mediates immune response in cancers but its impact on colitis development still unknown. Moreover, recent findings identified mature tethered agonist of which corresponds to Stachel sequence this receptor4. The purpose work design peptides corresponding able activate with higher activity than evaluate them model....
Abstract Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating evidence highlights the meaningful impact of estrogen receptors physiology and pathophysiology colon. However, significance G protein-coupled receptor (GPER) on Crohn’s disease (CD), one inflammatory bowel (IBD) types, is still elusive. Our study revealed GPER overexpression at mRNA protein levels patients with CD. To evaluate effects activation/inhibition colitis development, a murine 2, 4,...
Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role carcinogenesis, much remains learn regarding growth progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CSF is linked with metastasis human gastrointestinal tumors neutralizing a mouse model of colitis-associated cancer protective. Here, we set out identify its receptor, G-CSFR, CD4+ CD8+ T cell responses...
Background: The current treatment of gastroesophageal reflux disease (GERD) is focused on decreasing gastric acid secretion. However, there still a group patients that do not respond to conventional therapy. Proteinase-activated receptors and purinergic have been implicated in inflammation, visceral hyperalgesia esophageal hypersensitivity. aim this study was evaluate the expression PAR2 (F2RL1) P2RX2, P2RX3 P2RY2 GERD patients. Methods: A total 53 with 9 healthy controls were enrolled...
The <i>α</i>7 pentamer nicotinic acetylcholine receptors (nAChRs) are a target in transduction of anti-inflammatory signals from the central nervous system to gastrointestinal (GI) tract. aim this study was investigate action novel nAChR partial agonist encenicline and determine mechanism underlying its activity. Anti-inflammatory activity evaluated using trinitrobenzenesulfonic acid (TNBS)- dextran sulfate sodium (DSS)-induced models colitis. Macroscopic score, ulcer colon length thickness,...
Tumor-associated macrophages (TAMs) in the gastrointestinal tumor microenvironment (TME) are known to polarize into populations exhibiting pro- or anti-tumoral activity response stimuli such as growth factors and cytokines. Our previous work has recognized granulocyte colony-stimulating factor (G-CSF) a cytokine capable of influencing immune cells TME pro-tumoral activity. Here, we aimed focus on how G-CSF regulates TAM phenotype function effects (GI) progression. Thus, wildtype (WT)...
Ruthenium atoms located in the surfaces of carbosilane dendrimers markedly increase their anti-tumor properties. Carbosilane have been widely studied as carriers drugs and genes owing to such characteristic features monodispersity, stability, multivalence. The presence ruthenium dendrimer structure enhances successful use anti-cancer therapy. In this paper, activity generation 1 2 against 1301 cells was evaluated using Transmission Electron Microscopy, comet assay Real Time PCR techniques....
G protein-coupled receptor 30 (GPR30) is a recently de-orphanized estrogen that mediates the effects of estrogens on different cells. It has been postulated in inflammatory bowel diseases (IBD) activation GPR30 blocks pathways dependent pro-inflammatory cytokines. The aim our study was to investigate expression patients with IBD and its potential implication future therapies.Fifty-seven were enrolled study: 20 subjects Crohn's disease (CD), 22 ulcerative colitis (UC) 15 controls. In each...
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder affecting 9-23% of the world's population, with higher prevalence among women. IBS complex influenced by psychosocial, physiological, and genetic factors, exacerbated stress.
Pharmacological treatment and/or maintenance of remission in inflammatory bowel disease [IBD] is currently one the biggest challenges field gastroenterology. Here we aimed to assess anti-inflammatory effect and mechanism action sialorphin, natural blocker endogenous opioid peptide-degrading enzymes neprilysin [NEP] aminopeptidase N [APN], mouse models IBD changes expression these patients.We used two experimental colitis mice [2,4,6-trinitrobenzene sulphonic acid [TNBS]- dextran sulphate...
Abstract Background GPR18 is a recently deorphanized receptor which was reported to act with several endogenous cannabinoid ligands. Here, we aimed describe the role of in intestinal inflammation and inflammatory pain. Methods The anti‐inflammatory activity selective agonist, PSB‐KK‐1415, antagonist, PSB‐CB5, characterized semi‐chronic chronic mouse models colitis induced by 2,4,6‐trinitrobenzenesulfonic acid (TNBS). extent evaluated based on macroscopic microscopic scores, quantification...
To investigate the levels of G protein-coupled receptor 55 (GPR55) expression in colonic tissue inflammatory bowel disease (IBD) patients and healthy controls, its potential implication IBD treatment.Fifty were enrolled our prospective study: n = 21 with Crohn's (CD) 16 ulcerative colitis (UC); 19 women 18 men. Control consisted 13 non-IBD patients. In each subject, two biopsies taken from different locations. patients, both endoscopically inflamed non-inflamed areas drawn development...