A5007346802- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Metabolomics and Mass Spectrometry Studies
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Pesticide Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cassava research and cyanide
- Quantum Dots Synthesis And Properties
- Characterization and Applications of Magnetic Nanoparticles
- Photoacoustic and Ultrasonic Imaging
- Multicomponent Synthesis of Heterocycles
- Nanoparticles: synthesis and applications
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
- SARS-CoV-2 detection and testing
- Poisoning and overdose treatments
- Protease and Inhibitor Mechanisms
- Injury Epidemiology and Prevention
- Microwave-Assisted Synthesis and Applications
Medical University of Warsaw
2015-2024
University of Warsaw
2023
Abstract Background Lung cancer is one of the most frequently diagnosed cancers all over world and also leading causes cancer-related mortality. The main treatment option for small cell lung cancer, conventional chemotherapy, characterized by a lack specificity, resulting in severe adverse effects. Therefore, this study aimed at developing new targeted drug delivery (TDD) system based on Ag–In–Zn–S quantum dots (QDs). For purpose, QD nanocrystals were modified with 11-mercaptoundecanoic acid...
Tetraspanins, including CD9, CD63, and CD81, are transmembrane biomarkers that play a crucial role in regulating cancer cell proliferation, invasion, metastasis, as well plasma membrane dynamics protein trafficking. In this study, we developed simple, fast, sensitive immunosensors to determine the concentration of extracellular vesicles (EVs) isolated from human lung cells using tetraspanins biomarkers. We employed surface plasmon resonance (SPR) quartz crystal microbalance with dissipation...
Recent advances in nanomedicine have paved the way for developing targeted drug delivery systems. Nanoscale exosomes are present almost every body fluid and represent a novel mechanism of intercellular communication. Because their membrane origin, they easily fuse with cells, acting as natural system maintaining bioactivity immunotolerance cells. To develop reconstitutable exosome-based candidate clinical applications, quality assurance by preserving its physical biological properties during...
Extracellular vesicles (EVs) released from primary cell lines, originating resected tissues during biopsies in patients with non-small lung cancer (NSCLC) revealing adenocarcinoma and squamous carcinoma subtypes, were examined for membrane proteomic fingerprints using a proximity barcoding assay. All the collected EVs expressed canonical tetraspanins (CD9, CD63, CD81) highly coexpressed molecules such as lysosome-associated protein-1 (LAMP1-CD107a), sialomucin core protein 24 (CD164), Raph...
Iron( iii ) oxide nanoparticles doped with magnesium exposed to an alternating magnetic field induced cytotoxic effects on lung cancer cells (A549).
Personalized medicine is a new approach to modern oncology. Here, facilitate the application of extracellular vesicles (EVs) derived from lung cancer cells as potent advanced therapy medicinal products in cancer, EV membrane was functionalized with specific ligand for targeting purposes. In this role, most effective heptapeptide binding (PTHTRWA) used. The functionalization process surface performed through C- or N-terminal end heptapeptide. To prove activity EVs PTHTRWA, both model lipid...
Cyanides are infamous for their highly poisonous properties. Accidental cyanide poisoning occurs frequently, but occasionally, intentional poisonings also occur. Inhalation of fumes generated by fire may cause poisoning. There many limitations in direct analysis cyanide. 2-Aminothiazoline-4-carboxylic acid (ATCA), a metabolite, seems to be the only surrogate that is being used detection because its stability and cyanide-dependent quality biological matrix. Unfortunately, toxicokinetic...
Abstract Background Lung cancer is one of the most frequently diagnosed all over world and a leading cancer-related mortality. The therapy lung includes surgery, chemotherapy radiatherapy mailny depends on type stage characterized based WHO guidelines. Althought conventional main treatment option for small cell (SCLC) common non-SCLC it with lack specificity resulting to severe toxicities normal cells harmful side effects. Therefore, targeted drug delivery (TDD) systems have been used reduce...
This work presents a new look at the application of cyclodextrins (CD) as drug nanocarrier. Two different (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). Here, we demonstrated that combination αCD and βCD enabled load control release two anticancer drugs: doxorubicin (DOX) beta-lapachone (beta-LP) (DOX in β-CD beta-LP into α-CD) via host-guest inclusion. The PEI-βCD(DOX)-αCD-FA nanoconjugate...
Abstract Background Magnetic fluid hyperthermia (MFH) represents a promising therapeutic strategy in cancer utilizing the heating capabilities of magnetic nanoparticles when exposed to an alternating field (AMF). Because efficacy and safety MFH treatments depends on numerous intrinsic extrinsic factors, therefore, proper setups should focus thermal energy dosed into cells. Methods In this study, we performed experiments using human lung A549 cells (in vitro) NUDE Balb/c mice bearing (A549)...
An amendment to this paper has been published and can be accessed via the original article.