A5039805418- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Energy and Environment Impacts
- DNA Repair Mechanisms
- Ovarian cancer diagnosis and treatment
- Congenital Diaphragmatic Hernia Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial biofilms and quorum sensing
- Renal and related cancers
- Synthesis and biological activity
- Hemodynamic Monitoring and Therapy
- Autoimmune Bullous Skin Diseases
- Hepatitis B Virus Studies
- Electrodeposition and Electroless Coatings
- Intestinal Malrotation and Obstruction Disorders
- Cancer Research and Treatment
- Urologic and reproductive health conditions
- Ultrasound and Hyperthermia Applications
- Biochemical effects in animals
- Electrocatalysts for Energy Conversion
- Corrosion Behavior and Inhibition
- Graphene and Nanomaterials Applications
- Genital Health and Disease
- Synthesis and Characterization of Heterocyclic Compounds
The Maria Sklodowska-Curie National Research Institute of Oncology
2013-2023
Danylo Halytsky Lviv National Medical University
2021
Jan Kochanowski University
2015-2021
Centrum Medyczne Kształcenia Podyplomowego
2019
Medical University of Lublin
2018
Górnośląskie Centrum Medyczne
2013
Centrum Onkologii
2013
Institute of Pharmacology
2007
Polish Academy of Sciences
2007
University at Buffalo, State University of New York
2006
Biodiesels represent more carbon-neutral fuels and are introduced at an increasing extent to reduce emission of greenhouse gases. However, the potential impact different types blend concentrations biodiesel on toxicity diesel engine emissions still relatively scarce some contradictory. The objective present work was compare exhaust particles (DEP) from combustion two 1st-generation fuels: 7% fatty acid methyl esters (FAME; B7) 20% FAME (B20) a 2nd-generation FAME/HVO (synthetic hydrocarbon...
Bacterial surface structures of a proteinic nature and glycoconjugates contribute to biofilm formation provide shields host defense mechanisms (e.g., the complement system phagocytosis). A loss or alteration these molecules, leading phage resistance, could result in fewer virulent bacteria. In this study, we evaluate biology phenotype changes Pseudomonas aeruginosa PAO1 phage-resistant clones, which emerge phage-treated biofilms. We characterize clones for phage-typing patterns, antibiotic...
Bicifadine (1-<i>p</i>-tolyl-3-azabicyclo[3.1.0]hexane) inhibits monoamine neurotransmitter uptake by recombinant human transporters in vitro with a relative potency of norepinephrine > serotonin dopamine (≈1:2:17). This profile is supported microdialysis studies freely moving rats, where bicifadine (20 mg/kg i.p.) increased extrasynaptic and levels the prefrontal cortex, locus coeruleus, striatum. Orally administered an effective antinociceptive several models acute, persistent, chronic...
Epidemiological data indicate that exposure to diesel exhaust particles (DEPs) from traffic emissions is associated with higher risk of morbidity and mortality related cardiovascular pulmonary diseases, accelerated progression atherosclerotic plaques, possible lung cancer. While the impact DEPs combustion fossil fuel on human health has been extensively studied, current knowledge biofuels provides limited inconsistent information about its mutagenicity genotoxicity, as well adverse risks....
Summary.— The authors describe a case of pemphigus, confirmed histologically (acantholysis) and by immunofluorescence studies (circulating pemphigus autoantibodies in the titre 1:1280, vivo bound immunoglobulins IgG, complement intercellular substance epidermis). symptoms developed 10 months after burn which refused to heal involved site other skin areas. possible connection between development is discussed light reports pemphigus-like antibodies burns, normally appear temporarily some...
Biodosimetric methods used to measure the effects of radiation are critical for estimating health risks irradiated individuals or populations. The direct measurement radiation-induced γ-H2AX foci in peripheral blood lymphocytes is one approach that provides a useful end point triage. Despite documented advantages assay, there considerable variation among laboratories regarding formation same exposure conditions and cell lines. Taking this into account, goal our study was evaluate influence...
Purpose: To assess the recurrence and birth rates among patients with non-epithelial ovarian cancer. Methods: The study included 146 germ cell (GCT, n = 84) sex cord-stromal tumors (SCST, 62), who underwent fertility-sparing surgery. Adjuvant chemotherapy was administered to 86 (58.9%) patients. Most cases (133 out of 146) were staged FIGO I. Results: 5- 10-year disease-free survival 91% 83%, respectively. risk not associated tumor histology, stage or age. Twenty-four months after treatment,...
The use of hyperthermic intraperitoneal perfusion chemotherapy has allowed to significantly improve treatment outcomes in patients with cancer dissemination within the peritoneal cavity. intraoperative is based on a enhanced efficacy oncolytic drugs when acting at temperature 42–43°C. paper presents an accurate description anesthetic management undergoing (HIPEC). suggested method was developed literature data as well own clinical observations. Particular emphasis placed maintenance...
The study of drugs diffusion through different biological membranes constitutes an essential step in the development new pharmaceuticals. In this study, method based on monolayer cell culture CHO-K1 cells has been developed order to emulate epithelial barrier permeability studies by laser interferometry. Laser interferometry was employed for experimental analysis nickel(II) and cobalt(II) complexes with 1-allylimidazole or their chlorides’ eukaryotic monolayers. amount (mol) chlorides...
Objective: Recombinant adeno-associated virus (rAAV) type 2 is a common vector used in gene therapy. However, the presence of anti-AAV2 neutralizing antibodies or other factors can significantly limit effective transduction. Intraperitoneal therapy could enable local delivery target directly to ovarian cancer cells. Until now, there have been no reports on anti-AAV ascitic fluid, which might effectiveness rAAV as candidate for intraperitoneal Thus, characterization preexisting neutralization...
Gynecological cancers constitute a serious problem in the world. Their advanced stages are often characterized by accumulation of ascites, which leads to spreading cancer cells outside their primary focus. Despite progress treatment, prognoses still not satisfactory. The main causes these failures chemoresistance, metastases and recurrences disease, is influenced by, among others, microenvironment cells. This study investigated effect microenvironment, create ascites derived from patients...
Ovarian clear cell carcinoma belongs to rather rare ovarian neoplasms and is believed be a separate disease with a...
1. Hagmar L, Bonassi S, Strömberg U, Mikoczy Z, Lando C, Hansteen I-L, Montagud AH, Knudsen Norppa H, Reuterwall Ch, Tinnerberg Brøgger A, Forni Högstedt B, Lambert Mitelman F, Nordenson I, Salomaa Skerfving S. Canser predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the Europen Study on Cytogenetic. Mutat Res. 1998; 405: 171–178. Google Scholar
Increased use of 1st and 2nd generation biofuels raises concerns about health effects new emissions. We analyzed cellular molecular lung in Fisher 344 rats exposed to diesel engine exhaust emissions (DEE) from a Euro 5-classified running on B7: petrodiesel fuel containing 7% fatty acid methyl esters (FAME), or SHB20 (synthetic hydrocarbon biofuel): FAME 13% hydrogenated vegetable oil. The were for 7 consecutive days (6 h/day) 28 h/day, 5 days/week), both with without particle filter (DPF)...
<b>Introduction:</b> Congenital diaphragmatic hernia (CDH) is a rare disorder that can result in serious complications and even death of the child. The presence abdominal organs chest cavity prenatal period disturbs proper development lungs eventually may lead to their hypoplasia respiratory failure. <b>Case Report:</b> We presented 4 cases children aged 2 9 years, which X-ray images suggested staphylococcal pneumonia or pleural pneumothorax. These were circulatory, efficent, them developing...
In the article, we investigate use of lamotrigine in patients required special caution during epilepsy treatment. Lamotrigine provides optimal control disease before pregnancy, which gives a chance to maintain this state pregnancy. has not got teratogenic effect, that’s why it can be administrated with comorbid mood disorders, is stabilizing neuronal membranes and inhibition glutamate release, both cause antidepressant normothymic effect. This effect so strong that currently, registered...