Growing evidence of transcriptional and metabolomic differentiation induced many studies which analyze such in context outcome disease progression, treatment or influence different factors affecting cellular tissue metabolism. Particularly, cancer researchers are looking for new biomarkers that can serve as a diagnostic/prognostic factor its further corresponding relationship regarding clinical effects. As result the increasing interest use dichotomization continuous variables involving...

The medial parietooccipital and peritrigonal areas present challenges for neurosurgical procedures. Adjacency to the eloquent cortex-postcentral gyrus cuneus, as well crucial white matter tracts, such optic radiation-makes surgical approaches difficult. This study aims describe technique outcomes of treating lesions using contralateral approach. is a retrospective analysis 19 cases treated in Department Neurosurgery Neurooncology, Copernicus Memorial Hospital, Łódź between April 2021 May...

Abstract Lung malignancies comprise lethal and aggressive tumours that remain the leading cancer-related death cause worldwide. Regarding histological classification, lung squamous cell carcinoma (LUSC) adenocarcinoma (LUAD) account for majority of cases. Surgical resection various combinations chemo- radiation therapies are golden standards in treatment cancers, although five-year survival rate remains very poor. Notch, Hedgehog, Wnt Erbb signalling evolutionarily conserved pathways...

Notch signaling is an evolutionarily conserved pathway regulating normal embryonic development and homeostasis in a wide variety of tissues. It also critically involved carcinogenesis, as well cancer progression. Activation the members can be either oncogenic or suppressive, depending on tissue context. The present study comprehensive overview, extended with bioinformatics analysis TCGA cohorts, including breast, bladder, cervical, colon, kidney, lung, ovary, prostate rectum carcinomas. We...

Prostate carcinoma (PRAD) is one of the most frequently diagnosed malignancies amongst men worldwide. It well-known that androgen receptor (AR) plays a pivotal role in vast majority prostate tumors. However, recent evidence emerged stating estrogen receptors (ERs) may also contribute to tumor development. Moreover, progression and aggressiveness cancer be associated with differential expression genes epithelial-to-mesenchymal transition (EMT). Therefore we aimed assess significance status as...

Most of the currently used cancer immunotherapies inhibit programmed cell death protein 1 (PD1)–programmed ligand (PDL1) axis T‐cells. However, dendritic cells (DCs) controlled by natural killer (NK) via FMS‐related tyrosine kinase 3 (FLT3) are necessary for activation The aim study was to evaluate FLT3 as a prognostic factor and determine its role in immune infiltration (with emphasis on NK DCs). Using Cancer Genome Atlas (TCGA) database, we performed bioinformatic analysis gene expression...

The current standard of care (SoC) for patients with extensive-disease small-cell lung cancer (ED-SCLC) is chemo-immunotherapy. efficacy radiotherapy (RT) chest consolidation has been established ED-SCLC who have responded to chemotherapy. There a lack data on incorporating RT as and metastasis-directed therapy ED-SCLC. RISE (Radiotherapy Extensive-Stage Small-Cell Lung Cancer) study aims evaluate the effectiveness different strategies residual lesions receive A total 165 will be recruited,...

Abstract Purpose The standard treatment for oligometastatic colorectal cancer includes systemic therapy, with surgery and metastasis-directed therapy as options. optimal strategy, especially repeat oligoprogression (rOP), remains unclear. We report outcomes of liver computer tomography-guided high-dose rate brachytherapy (CT-BRT) in this setting. Methods This retrospective cohort study included patients liver-only during meeting criteria up to 5 metastases, CT-BRT eligibility, ECOG status ≤...

The molecular determinants of the heterogenic course prostate cancer (PC) remain elusive. We aimed to determine drivers predisposing unfavorable PC outcomes anticipated by BCR events among patients similar preoperative characteristics. TCGA transcriptomic and clinical data 497 individuals were used, stratified according risk EAU-EANM-ESTRO-ESUR-SIOG. relevance functional markers regarding BCR-free survival was examined cutp algorithm. Through UpSetR, subgroups bearing an signature...

Introduction: Notch signalling, an evolutionarily conserved mechanism of cellular differentiation and tissue remodelling, is frequently deregulated in several human malignancies, including renal cell carcinoma (RCC).However, the prognostic value individual pathway members RC subtypes remains indefinable.The present study investigates whether differential expression has a contrary effect on disease-free survival (DFS) clear (KIRC), papillary (KIRP) chromophobe (KICH) patients.Material...

The optimal sequence of chemoradiotherapy with immunotherapy is still not established. patient’s immune status may play a role in determining this order. We aim to determine the kinetics multi-potential haemopoietic factor FMS-related tyrosine kinase 3 ligand (Flt-3L) during chemoradiotherapy. Our pilot, single arm prospective study, enrolled patients rectal cancer who qualified for neoadjuvant Blood samples Flt-3L were collected before and every second week complete blood count week....

Breast cancer (BC) is characterized by high heterogeneity regarding its biology and clinical characteristics. The Notch pathway regulates such processes as organ modeling epithelial-to-mesenchymal transition (EMT).The aim of the study was to determine effect differential expression members on disease-free survival (DFS) in luminal type A (lumA) triple negative (TN) BC.The 19 examined a TCGA BC cohort. DFS analysis performed using log-rank test (p<0.05). Biological differences between groups...

Background: Cellular metabolism is a tightly controlled process during which cell growth and survival are maintained. Lung cancer disease with clear sex differences, where female patients have better rates than males. Evidence of differences demonstrated in risk, prognosis response to different therapies, yet sex-specific approach studies not widely considered. These tumour characteristics attributed that impact outcome, including constitutional genetic somatic molecular make it essential...

Abstract Smoking accounts for almost 80–90% of lung cancer cases, which is also the most frequent cause cancer-related deaths in humans. With over 60 carcinogens tobacco smoke, cells dividing at time carcinogen exposure are particular risk neoplasia. The present study aimed to investigate global gene expression differences adenocarcinoma (LUAD) tumour samples current smokers and non-smokers, an attempt elucidate biological mechanisms underlying divergent smoking effects. Current non-smoker...

The Notch pathway involves evolutionarily conserved signaling regulating the development of female tract organs such as breast, ovary, cervix, and uterine endometrium. A great number studies revealed aberrancies in association with their carcinogenesis disease progression, management which is still challenging. present study a comprehensive review available literature on during normal organs. has been enriched our analyses TCGA data including cervical, ovarian, endometrial carcinomas...

The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. WWOX gene non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis migration processes. Moreover, genetic aberrations in induce severe neuropathological phenotypes humans rodents. aim present study was investigate detail human neural progenitor cell (hNPC) maintenance how depletion disturbs signaling pathways...

Gliomas are the predominant cause of cancer-related deaths among young population. Even after incorporation IDH1/2 mutations and 1p19q codeletion there doubts regarding adjuvant treatment in WHO G2/G3 gliomas. miRNA molecules control about 30% all genes, also many oncogenes, tumor suppressor genes responsible for response to ionizing radiation systemic treatment. Patients with brain gliomas exhibit disorders. We aimed evaluate expression miR-200 family members relation selected...

Breast cancer (BC) remains a significant healthcare challenge. Routinely, the treatment strategy is determined by immunohistochemistry (IHC)-based assessment of key proteins such as estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), and Ki-67. However, it estimated that over 75% deaths result from metastatic tumors, indicating need to develop more accurate protocols for intertumoral heterogeneity their consequences on prognosis. Therefore, aim this preliminary...

Abstract Background Among all causes of death, cancer is the most prevalent and only outpaced by cardiovascular diseases. Molecular theory carcinogenesis states that apoptosis proliferation are regulated groups tumor suppressors or oncogenes. Transcription factors example proteins comprising representatives both cancer-related groups. Exemplary family transcription which exhibits dualism function Activating enhancer-binding Protein 2 (AP-2). Scientific reports concerning their in depend on...

Abstract The coronavirus disease 2019 (COVID-19) outbreak is a worldwide pandemic problem that started in China December and within few months spread to all continents. Very high infectivity of SARS-CoV-2 virus substantial severity caused medical care capacity shortage many countries. Therefore, real-time epidemic forecasting the COVID-19 useful plan public health strategies like country lockdown healthcare reorganization. We used extended susceptible-infected-removed (eSIR) model predict...

Abstract Background WW Domain Containing Oxidoreductase ( WWOX ) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors. Thus, using lentiviral systems we created an vitro model overexpressing or downregulating CAL-29 cell line assess invasiveness pathways. Surprisingly, while overexpression was accompanied increased expression of both AP-2...

WWOX is a tumor-suppressive steroid dehydrogenase, which relationship with hormone receptors was shown both in animal models and breast cancer patients. Herein, through nAnT-iCAGE high-throughput gene expression profiling, we studied the interplay of estrogen cell lines (MCF7, T47D, MDA-MB-231, BT20) under stimulation either introduction by retroviral transfection (MDA-MB-231, T47D) or silenced shRNA BT20). Additionally, evaluated consequent biological characteristics proliferation,...

Functional single-nucleotide polymorphisms (SNPs) in genes regulating cellular uptake, elimination, and metabolism of xenobiotics may potentially influence the outcome chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKI). Dasatinib, a second-generation TKI, is substrate ABC-superfamily xenobiotic transporters ABCB1 (MDR1, Pg-P) ABCG2 (BCRP). Pregnane X receptor (PXR, NR1I2) constitutive androstane (CAR, NR1I3) are involved control expression