A5087917466- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Epigenetics and DNA Methylation
- Vascular Malformations Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Spinal Fractures and Fixation Techniques
- Advanced Chemical Sensor Technologies
- Management of metastatic bone disease
- Medical and Biological Sciences
- Anatomy and Medical Technology
- Cervical and Thoracic Myelopathy
- Bone fractures and treatments
- Analytical chemistry methods development
- Advanced Proteomics Techniques and Applications
University of Bydgoszcz
2012-2025
Bydgoszcz University of Science and Technology
2024-2025
AGH University of Krakow
2024-2025
Poznan University of Medical Sciences
2024
Military Hospital
2020-2023
Copernicus Memorial Hospital
2022
Collegium Medicum in Bydgoszcz
2022
Nicolaus Copernicus University
2022
1 Military Clinical Hospital with Outpatient Clinic
2022
4. Wojskowy Szpital Kliniczny z Polikliniką
2000-2012
Abstract Accurate determination of the extent and grade adult-type diffuse gliomas is critical to patient management. In clinical practice, contrast-enhancing areas in magnetic resonance imaging (MRI) sequences are usually used target biopsy, surgery, radiation therapy, but there can be discrepancies between these actual tumor extent. Here we show that adding 18 F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) MRI accurately locates most malignant gliomas, potentially impacting...
The medial parietooccipital and peritrigonal areas present challenges for neurosurgical procedures. Adjacency to the eloquent cortex-postcentral gyrus cuneus, as well crucial white matter tracts, such optic radiation-makes surgical approaches difficult. This study aims describe technique outcomes of treating lesions using contralateral approach. is a retrospective analysis 19 cases treated in Department Neurosurgery Neurooncology, Copernicus Memorial Hospital, Łódź between April 2021 May...
Glioblastoma is the most malignant central nervous system tumor, which represents 50% of all glial tumors. The understanding glioma genesis, prognostic evaluation, and treatment planning has been significantly enhanced by discovery molecular genetic biomarkers. This study aimed to evaluate survival in patients with primary glioblastoma concerning O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation other clinical factors. included 41 newly diagnosed treated from 2011 2014 10th...
The accurate detection of genetic variants such as single substitutions (IDH1/2, TERT), chromosomal abnormalities (CDKN2A, 1p/19q deletions, and EGFR amplifications), or promoter methylations (MGMT) is critical for glioma patient management, emphasized in the World Health Organization's (WHO's) most recent classification 2021 (WHO CNS5). purpose this study was to evaluate novel innovative methods determining IDH1/2 status context WHO CNS5. Multiple biomarkers were simultaneously screened...
While most studies on the postoperative condition of patients with spinal cord tumors describe long-term outcomes, data are needed immediate surgical outcomes demanding rehabilitation to make informed assessments for planning. The aim this study was identify factors predicting function and rehabilitative needs after intradural tumor surgery. Eighty-five prospectively recruited underwent surgery intramedullary (ID-IM; n = 23) extramedullary (ID-EM; 62) tumors. Neurological functional status...
The mutation in NF2 is the most common alteration associated with meningioma oncogenesis, and it related to loss of a suppressing protein called merlin. At same time, alterations energy production are visible cancer cells, where increased demands for observed. Fatty acid oxidation could be one ways cells obtain energy. This metabolic pathway uses acylcarnitine shuttle system, which responsible acylation fatty acids their transport through mitochondria. Therefore, this study aimed profile...
INTRODUCTION: Dural tenting sutures are a well-known neurosurgical technique. However, their use in preventing extradural hematomas (EDHs) lacks evidence-based support. For that reason, we deemed it necessary to evaluate this technique an evidence–based manner. METHODS: This is report of randomized, multi-center, investigator- and participant-blinded, controlled interventional non-inferiority trial with 1:1 allocation (NCT03658941). We included adults undergoing elective, supratentorial...
Abstract It is extremely challenging to perform chemical analyses of the brain, particularly in humans, due restricted access this organ. Imaging techniques are primary approach used clinical practice, but they only provide limited information about brain chemistry. Solid-phase microextraction (SPME) has been presented recently as a biopsy tool for study animal brains. The current work demonstrates first time use SPME spatially resolved sampling human vivo. Specially designed multi-probe...
Background. Motor cortex stimulation is one of the neuromodulation methods treating refractory central neurogenic pain.Objectives. . The aim this study was to retrospectively evaluate effects motor stimulation.Material and Methods. group consisted 14 consecutive patients with thalamic pain, atypical facial post-brachial plexus avulsion injury phantom pain in syringomyelia who were treated at Department Neurosurgery Military Research Hospital Bydgoszcz, Poland, from 2005 2013. procedures...
The development of a fast and accurate intraoperative method that enables the differentiation stratification cancerous lesions is still challenging problem in laboratory medicine. Therefore, it important to find optimize simple effective analytical enabling selection distinctive metabolites. This study aims assess usefulness solid-phase microextraction (SPME) probes as sampling for lipidomic analysis brain tumors. To this end, SPME was applied sample tumors immediately after excision,...
Alterations in the carnitine shuttle system may be an indication of presence cancer. As such, in-depth analyses this pathway different malignant tumors could important for detection and treatment disease. The current study aims to assess profiles acylcarnitines gliomas with respect their grade, isocitrate dehydrogenase (IDH) mutations, 1p/19q co-deletion. Brain obtained from 19 patients were sampled on-site using solid-phase microextraction (SPME) immediately following excision. Analytes...
Glioblastoma multiforme is one of the most malignant neoplasms among humans in their third and fourth decades life, which evidenced by short patient survival times rapid tumor-cell proliferation after radiation chemotherapy. At present, diagnosis gliomas decisions related to therapeutic strategies are based on genetic testing histological analysis tumor, with molecular biomarkers still being sought complement diagnostic panel. This work aims enable metabolomic characterization cancer tissue...
Brain tumors are neoplasms with one of the highest mortality rates. Therefore, availability methods that allow for quick and effective diagnosis brain selection appropriate treatments is critical importance patient outcomes. In this study, coated blade spray-mass spectrometry (CBS-MS), which combines features microextraction fast ionization methods, was applied analysis tumors. approach, a sword-shaped probe sorptive material to enable extraction analytes from biological samples. The then...
IDH1 (isocitrate dehydrogenase 1) is a potential biomarker and drug target. Genomic epigenetic data on astrocytoma have demonstrated that the mutation sufficient to establish glioma hypermethylator phenotype. Furthermore, recent studies also indicated mutant inhibitor induced demethylation of histone H3K9me3 expression genes associated with gliogenic differentiation. As presence p.R132H in gene seems be more powerful prognostic marker than O(6)-methylguanine-DNA methyltransferase promoter...
Gliomas are common brain tumours, but obtaining tissue for definitive diagnosis can be difficult. There is, therefore, interest in the use of non-invasive methods to diagnose and grade disease. Although positron emission tomography (PET) with 18F-fluorethyltyrosine (18F-FET) used differentiate between low-grade (LGG) high-grade (HGG) gliomas, optimal parameters measure their cut-points have yet established. We therefore assessed value single dual time-point acquisition 18F-FET PET primary...
Stereotactic biopsy of posterior fossa lesions is often regarded as hazardous due to the critical structures in that area. Therefore, aim study was evaluate diagnostic accuracy and safety infratentorial stereotactic brainstem or cerebellar its associations with other clinical, laboratory, radiological parameters. From January 2000 May 2021, 190 biopsies tumors, including 108 lesions, were performed. Moreover, 63 supratentorial cerebral peduncle analyzed compare efficacy both approaches....