A5068015233- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cardiac tumors and thrombi
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Bone health and treatments
- CNS Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Chronic Myeloid Leukemia Treatments
- Gastrointestinal disorders and treatments
Nicolaus Copernicus University
2015-2024
Collegium Medicum in Bydgoszcz
2015-2024
University of Bydgoszcz
2009-2021
Memorial Hospital
2019
GTx (United States)
2018
Centrum Onkologii
2007-2018
Mount Sinai Medical Center
2014
Roswell Park Comprehensive Cancer Center
2014
NewYork–Presbyterian Hospital
2014
Cornell University
2014
At present, there are no standard criteria that have been validated for interim PET reporting in lymphoma. In 2009, an international workshop attended by hematologists and nuclear medicine experts Deauville, France, proposed to develop simple reproducible rules Accordingly, validation study was undertaken with the primary aim of validating prognostic role using Deauville 5-point score evaluate images secondary measuring concordance rates among reviewers same score. This paper focuses on...
Abstract Accurate determination of the extent and grade adult-type diffuse gliomas is critical to patient management. In clinical practice, contrast-enhancing areas in magnetic resonance imaging (MRI) sequences are usually used target biopsy, surgery, radiation therapy, but there can be discrepancies between these actual tumor extent. Here we show that adding 18 F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) MRI accurately locates most malignant gliomas, potentially impacting...
Negative [(18)F]fluorodeoxyglucose (FDG) -positron emission tomography (PET)/computed (CT) after two cycles of chemotherapy indicates a favorable prognosis in Hodgkin lymphoma (HL). We hypothesized that the negative predictive value would be even higher patients responding rapidly enough to PET one cycle. This prospective study aimed assess prognostic cycle HL and dynamics FDG uptake (PET1) (PET2).All scans were read by blinded, independent reviewers different countries, according Deauville...
PURPOSE The role of consolidation radiotherapy in patients with primary mediastinal B-cell lymphoma (PMBCL) is controversial. METHODS IELSG37 trial, a randomized noninferiority study, aimed to assess whether irradiation can be omitted PMBCL complete metabolic response (CMR) after induction immunochemotherapy. end point was progression-free survival (PFS) at 30 months random assignment. Patients CMR were randomly assigned observation or (30 Gy). With margin 10% (assuming 30-month PFS 85% both...
Purpose The five point Deauville (D) scale is widely used to assess interim PET metabolic response chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and D4,5. Inter-reader reliability of whole not well characterised. Methods Five international expert readers scored 100 PET/CT scans from paediatric Scans were acquired 51 European...
Purpose . The aim of this study was to determine if the preoperative maximum standardized uptake value (SUVmax) measured by 18F-FDG PET/CT in primary tumor has prognostic group patients with endometrial cancer. Patients, Materials, and Methods A total one hundred consecutive cancer patients, age range 40–82 years (mean 62 years) FIGO I–IV stage, who underwent 18-FDG-PET/CT within two weeks prior radical surgery, were enrolled study. SUV compared clinicopathologic features surgical specimens....
Accurately defining glioma infiltration is crucial for optimizing radiotherapy and surgery, but heterogeneous MRI imperfectly defines the tumor extent. Currently, it impossible to determine gradient within a FLAIR signal. O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET often reveals high-grade beyond contrast-enhancing areas on MRI. Here, we studied FET uptake dynamics in normal brain structures by dual-timepoint (10 min 40-60 post-injection) acquisition optimize analysis protocols infiltration....
We compared initial computed tomography (CT) and positron emission (PET)/CT in 96 patients with Hodgkin lymphoma (HL), assessing the role of baseline PET/CT stage migration treatment selection. The number I, II, III IV disease based on CT versus was: 5 vs. 7, 49 37, 28 22 14 30, respectively. In 33 (34%) patients, changed HL stage: 27 (28%) were upstaged six (6.3%) downstaged. Upstaging was caused by detection new extranodal involvements (47 sites 26 patients): bone marrow (10 patients),...
PET/CT-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment can be challenging. This study analyzed clinicopathologic correlations and prognostic meaning of different patterns (BM) <sup>18</sup>F-FDG uptake HL. <b>Methods:</b> One hundred eighty newly diagnosed early unfavorable advanced-stage HL patients, all scanned at baseline after 2 adriamycin-bleomycin-vinblastine-dacarbazine...
The management of residuals after completion chemotherapy in advanced seminoma is controversial. It has been proposed that fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used as a follow-up. In this study we investigated FDG-PET follow-up tool patients treated previously with or radiotherapy. Thirty-seven assigned to an group based on CT and/or FDG-PET/CT and then were included the study. All these underwent examination part scheme. Patients retroperitoneal lymph node...
Abstract Purpose: Dual timepoint fluoro-ethyl-tyrosine (FET)-PET acquisition (10 and 60 minutes after FET injection) improves the definition of glioblastoma (GBM) location shape. Here we evaluated safety efficacy simultaneous integrated boost (SIB) planned using dual FET-PET for postoperative GBM treatment. Patients Methods: In this prospective pilot study (March 2017–December 2020), 17 patients qualified FET-PET–based SIB intensity-modulated radiotherapy resection. The prescribed dose was...
Gliomas are common brain tumours, but obtaining tissue for definitive diagnosis can be difficult. There is, therefore, interest in the use of non-invasive methods to diagnose and grade disease. Although positron emission tomography (PET) with 18F-fluorethyltyrosine (18F-FET) used differentiate between low-grade (LGG) high-grade (HGG) gliomas, optimal parameters measure their cut-points have yet established. We therefore assessed value single dual time-point acquisition 18F-FET PET primary...
Streszczenie Liczba chorych na szpiczaka plazmocytowego zwiększa się, co jest skutkiem zarówno skuteczniejszej diagnostyki, jak również istotnego przedłużania przeżycia chorych. Zawdzięczamy to dostępności nowych leków w pierwszej i kolejnych liniach leczenia, zmianie koncepcji leczenia przedłużaniu czasu trwania stosując leczenie konsolidujące oraz podtrzymujące do progresji choroby. Poza zmianą zmienia się obecnie kryterium rozpoczęcia terapii uwzględniające biomarkery aktywności choroby...
Introduction:The aim of this study was to present a new predictive tool for non-sentinel lymph node (nSLN) metastases.Material and methods: One thousand five hundred eighty-three patients with early-stage breast cancer were subjected sentinel biopsy (SLNB) between 2004 2012.Metastatic SLNs found in 348 -the retrospective group.Selective axillary dissection (ALND) performed 94% cases.Involvement the nSLNs identified 32.1% following ALND.The correlation nSLN involvement selected...
Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a cutaneous form of chronic active Epstein-Barrvirus (EBV) infection, which can develop into the extremely rare systemic lymphoma. Patients with Inborn errors immunity (IEI), such as common variable immunodeficiency (CVID), are at higher risk developing severe course infections especially viral and malignancies than general population. The aim study was to present complex diagnostic therapeutic management HV-LPD. clinical...
Head and neck cancers (HNCs) are a group of tumors not common in European populations. So far, much is known about the role obesity, adipokines, glucose metabolism, inflammation pathogenesis HNC. The aim study was to determine concentrations ghrelin, omentin-1, adipsin, adiponectin, leptin, resistin, visfatin, glucagon, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), plasminogen activator inhibitor-1 (PAI-1), gastric inhibitory peptide (GIP) blood serum HNC patients depending on their...
Studies examining radiation-induced heart toxicity in breast cancer patients are inconclusive. The aim of this study was to prospectively and quantitatively asses myocardial blood flow (MBF) with, for the first time, 15O-H2O PET/CT as a marker damage irradiated patients.15 receiving intact or chest wall irradiation were included analysis (six with right-sided nine left-sided cancer). They underwent before radiotherapy (RT) 2 8 months after RT. MBF assessed at rest under stress conditions 17...
A satisfactory understanding of the clavicle development may be contributing to both diagnosis its congenital defects and prevention perinatal damage shoulder girdle. This study was carried out examine transverse sagittal diameters, cross-sectional area volume two fused primary ossification centers clavicle.Using methods CT, digital-image analysis statistics, size for in 42 spontaneously aborted human fetuses at ages 18-30 weeks studied.Without any male-female right-left significant...
Evaluation of FLT/PET/ CT usefulness in diagnosis and qualification for surgical treatment gastric cancer.The FLT/PET/CT test was carried out a group 50 cancer patients. Based on the result, decision followed about therapeutic procedure to be applied. A comparison made with regards consistency growth advancement degree evaluation initial preoperative against postoperative histopathology.In diagnosed patients used 37 21 resections were performed which 19 operations radical In 16 non-resective...
Objective The objective of this study was to investigate the morphologic features and 68Ga-prostate-specific membrane antigen (PSMA)-11 avidity celiac ganglia (CG) on multimodal PET/MRI. Materials methods 68Ga-PSMA-11 whole-body PET/MR examinations in 120 patients, referred for staging or follow-up prostate cancer, were retrospectively reviewed radiotracer uptake [maximum standardized value (SUVmax)] (size, shape, location) CG. Nodular, oval longitudinal nodular, thick with parts shapes CG...