A5089500996- Bladder and Urothelial Cancer Treatments
- Vitamin D Research Studies
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- Reproductive System and Pregnancy
- Urinary and Genital Oncology Studies
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Acne and Rosacea Treatments and Effects
- Endometriosis Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Nutrition and Health Studies
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Renal and related cancers
- T-cell and B-cell Immunology
- Gastrointestinal Tumor Research and Treatment
- Photodynamic Therapy Research Studies
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
Nicolaus Copernicus University
2013-2024
Collegium Medicum in Bydgoszcz
2013-2024
Centrum Onkologii
2011-2012
University of Bydgoszcz
2005
// Anna A. Brożyna 1, 2 , Wojciech Jóźwicki Krzysztof Roszkowski 3 Jan Filipiak 4 Andrzej T. Slominski 5, 6 1 Department of Tumour Pathology and Pathomorphology, Oncology Centre-Prof. Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz, Poland Faculty Health Sciences, Nicolaus Copernicus University Collegium Medicum in Oncology, Radiotherapy Gynecologic Chemotherapy, 5 Departments Dermatology Pathology, Alabama at Birmingham, AL, USA Laboratory Service the VA Medical Center...
Background:The broad spectrum of oxidative damage DNA biomarkers: urinary excretion 8-oxodG (8-oxo-7,8-dihydro-2'-deoxyguanosine), 8-oxoGua (8-oxo-7,8-dihydroguanine) as well the level in leukocytes, was analyzed cancer patients and healthy subjects.Material/Methods:222 134 volunteers were included analysis, using methodologies which involve HPLC (high-performance liquid chromatography) prepurification followed by gas chromatography with isotope dilution mass spectrometry detection...
Melanoma is highly resistant to current modalities of therapy, with the extent pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) constitutively activated melanoma and can serve as a molecular target for cancer therapy steroid/secosteroid action. Cultured cells were used mechanistic studies on NF-κB activity, utilising immunofluorescence, western blotting, EMSA, ELISA, gene reporter, estimated DNA synthesis assays. Formalin-fixed, paraffin-embedded...
The retinoic acid-related orphan receptors (RORs) regulate several physiological and pathological processes, including immune functions, development cancer. To study the potential role of RORs in melanoma progression, we analysed RORα RORγ expression nevi primary melanomas non-lesional skin metastases relation to clinico-pathomorphological features. was lower than decreased during with lowest levels found at stages III IV metastases. Their correlated pathomorphological pTNM parameters being...
Abstract Background The presence of regulatory T (Treg) cells in human endometrium is crucial for maintaining immunological homeostasis within the uterus. For this study we decided to evaluate subpopulations Treg conditions where a disturbance equilibrium ectopic and decidua has been observed, such as cases ovarian endometriosis (involving local immune cell suppression) pregnancy an increase system activity). We then compared these findings what observed normal eutopic women during secretory...
The major role of 24-hydroxylase (CYP24A1) is to maintain 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) homeostasis. Recently, it has been discovered that CYP24A1 also catalyses the hydroxylation 20(OH)D3, producing dihydroxy-derivatives show very effective antitumorigenic activities. Previously we showed a negative correlation vitamin D receptor (VDR) and CYP27B1 expression with progression, aggressiveness overall or disease-free survivals skin melanomas. Therefore, analyzed in relation...
Testing for the epidermal growth factor receptor (EGFR) gene mutations requires considerable multidisciplinary experience of clinicians (for appropriate patient selection), pathologists selection cytological or histological material) and geneticists performing reporting reliable molecular tests). We present our on efficacy routine EGFR testing in various types tumor samples frequency a large series Polish non-small cell lung cancer (NSCLC) patients.Deletions exon 19 substitution L858R 21...
In recent years, a significant number of studies have investigated the preventive role vitamin D in different neoplasms. this study, we analyze various components signaling pathways human uveal tract and melanoma, including analysis expression receptors (VDR), activating inactivating hydroxylases, respectively, CYP27B1 CYP24A1, retinoic acid-related orphan (ROR) α (RORα) γ (RORγ) these tissues. We further analyzed VDR, CYP27B1, ROR relation to melanin levels, clinical stage prognosis. Our...
Extracellular vesicles (EVs), including exosomes and microvesicles, together with apoptotic bodies form a diverse group of nanoparticles that play crucial role in intercellular communication, participate numerous physiological pathological processes. In the context cancer, they can allow transfer bioactive molecules genetic material between cancer cells surrounding stromal cells, thus promoting such processes as angiogenesis, metastasis, immune evasion. this article, we review recent...
The rapid development of molecular biology techniques allows for the introduction real-time polymerase chain reaction (PCR) methods with a limit mutation detection at 1 % in background wild-type DNA. Analysis KRAS mutations codons 12, 13, and 61, together analysis BRAF codon 600, are predictive biomarkers anti-epidermal growth factor receptor (EGFR) treatment colorectal cancer. Our aim was to compare PCR using DNA isolated from tissue samples previously evaluated presence tumor cells...
Vitamin D3 shows tumoristatic and anticancer effects by acting through the vitamin D receptor (VDR), while hydroxylation of 25-hydroxyvitamin at position 1α CYP27B1 is an essential step in its activation. The expression both VDR has been found many normal cancer tissues, but there a lack information about human bladder cancers. aim present research was to examine whether related prognostic markers disease outcome. We analyzed samples tumor tissues obtained from 71 urinary patients. highest...
Lung cancer is the leading cause of cancer-related death worldwide. Recent progress in lung diagnosis and treatment has been achieved due to a better understanding molecular mechanisms disease identification biomarkers that allow more specific treatments. One best known examples personalized therapy use tyrosine kinase inhibitors, such as gefitinib erlotinib, for successful non-small-cell patients selected based on EGFR mutations. Therefore, reliable detection mutations critical application...
// Wojciech Jóźwicki 1, 2 , Anna A. Brożyna Jerzy Siekiera 3 Andrzej T. Slominski 4, 5 1 Department of Tumour Pathology and Pathomorphology, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz, Bydgoszcz 85-796, Poland Oncology Centre-Prof. Franciszek Łukaszczyk Memorial Hospital, Urology, 4 Departments Dermatology Pathology, Alabama at Birmingham, AL 35294, USA VA Medical Center, 35233, Correspondence to: Jóźwicki, e-mail: jozwickiw@co.bydgoszcz.pl Keywords: Treg,...
The epidermal growth factor receptor (EGFR) mutation status in the tyrosine kinase domain is known to be a predictor of response gefitinib or erlotinib lung cancer; thus, non-surgical procedure tumor specimen collection critical for analysis. aim present study was analyze EGFR, KRAS and BRAF limited cytological material. To best our knowledge, this first time that quantitative scale cells percentage material were evaluated at early stages pathomorphological qualification Our results revealed...
The management of residuals after completion chemotherapy in advanced seminoma is controversial. It has been proposed that fluorodeoxyglucose-positron emission tomography (FDG-PET) can be used as a follow-up. In this study we investigated FDG-PET follow-up tool patients treated previously with or radiotherapy. Thirty-seven assigned to an group based on CT and/or FDG-PET/CT and then were included the study. All these underwent examination part scheme. Patients retroperitoneal lymph node...