A5003207746- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Management of metastatic bone disease
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Gynecological conditions and treatments
- Female Genital Mutilation/Cutting Issues
- Surgical site infection prevention
- Pancreatic and Hepatic Oncology Research
- Sexual Differentiation and Disorders
- Cancer Genomics and Diagnostics
Jagiellonian University
2024
The Maria Sklodowska-Curie National Research Institute of Oncology
1999-2018
Centrum Onkologii
1999
Colorectal cancer (CRC) is the second most common in Europe and a leading cause of death worldwide. Patient-derived xenograft (PDX) models maintain complex intratumoral biology heterogeneity therefore remain platform choice for translational drug discovery. In this study, we implanted 37 primary CRC tumors five cell lines into NU/J mice to develop models. Primary established xenografts were histologically assessed surveyed genetic variants gene expression using panel 409 cancer-related genes...
The aim of this study was to verify the accuracy existing scoring system for assessment anastomotic leakage risk after anterior resection and identify additional factors that were not included in classification.The 501 consecutive rectal cancer patients who underwent without formation protective stoma. determined using a previously proposed based on three factors: male sex, intraoperative blood loss level anastomosis.Symptomatic occurred 12.2% (61/501) our patients. Lower anastomosis...
Despite the findings of several randomized clinical studies, role gentamicin collagen implant (GCI) in rectal cancer surgery is unclear. Local pelvic application GCI following preoperative radiotherapy and total mesorectal excision (TME) was evaluated to determine risk surgical site infections (SSI).In this single-center trial, 176 patients with after preoperative, short-term (5 × 5 Gy) were either study group which used or control without GCI. Prior intraoperatively five excluded from...
A previous randomized study conducted by our group showed that application of gentamicin-collagen implant (GCI) into the pelvic cavity after total mesorectal excision (TME) reduced incidence distant metastases. Therefore, we decided to conduct a confirmatory study.Patients with rectal cancer were included in if they met following criteria: adenocarcinoma rectum, preoperative short-term radiotherapy (5 × 5 Gy), and WHO performance score 0-1.One hundred seventy-six patients randomly assigned...
Abstract Purpose The aim of this study was to compare surgical and sexual outcomes after Davidov-Moore vaginoplasty in women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). Methods In the case-series study, we described seven women, at a median age 22.6 ± BMI 22.8 2.3 kg/m 2 . We measured peri- postsurgical parameters, including surgery-related neovaginal length initiation time. Sexual were using Female Function Index (FSFI) before 6 months vaginoplasty. Results All procedures performed...
Abstract Aim Acceptance of a short distal bowel margin results in higher rate anterior resection but may compromise oncological safety. This study aimed to evaluate the safety 5‐mm margin. Method A retrospective analysis was carried out 412 consecutive patients with rectal cancer treated negative circumferential Radiotherapy given 63% an advanced tumour. The median follow up 75 months. Results Fewer group ≤ 5 mm had tumour pT stage compared > ( P = 0.033). Two were converted...
Introduction. Metastatic tumors in the pancreas constitute a small (2–5%), but steadily growing percentage of all neoplasms this organ. The aim study was to analyze surgical treatment metastases pancreas, particular its effectiveness and risk complications. Material methods. retrospective analysis performed on 21 patients treated surgically three centers. This group included 16 women (76%) 5 men (24%). median age at time diagnosis underlying disease 55.5 years (41–71). We analyzed location...