A5072789845- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Lymphoma Diagnosis and Treatment
- Pectus Deformity Diagnosis and Treatment
- Neurological Disorders and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Rheumatoid Arthritis Research and Therapies
- Medical Imaging and Pathology Studies
- Toxin Mechanisms and Immunotoxins
- Tracheal and airway disorders
- DNA Repair Mechanisms
- Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Metastasis and carcinoma case studies
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
Nicolaus Copernicus University
2013-2022
Collegium Medicum in Bydgoszcz
2012-2022
Ipsen (United States)
2017-2018
University of Bydgoszcz
2004-2015
Centrum Onkologii
2003-2010
Lublin Oncology Center
2009
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2005
Medical University of Lodz
1999
Military Medical Academy
1998-1999
Institute of Cardiology
1999
Background: The level of 8-oxoguanine (8-oxoG), a general marker oxidative DNA damage, in is the result both an equilibrium between rates its formation and removal from by repair enzymes 8-oxodGTP cellular nucleotide pool hydrolysis to 8-oxodGMP, preventing incorporation into DNA. To determine contribution each component 8-oxoG DNA, we compared 8-oxoG–excising activity (encoded hOGG1), 8-oxodGTPase hMTH1), levels tumors surrounding normal lung tissues non–small-cell cancer patients. Methods...
// Karol Czubak 1 , Marzena Anna Lewandowska 2, 3 Katarzyna Klonowska Krzysztof Roszkowski 4, 5 Janusz Kowalewski 3, 6 Marek Figlerowicz Piotr Kozlowski European Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, Polish Academy Sciences, Poznan, Poland 2 Molecular Oncology Genetics Department, Innovative Medical Forum, The Franciszek Lukaszczyk Center, Bydgoszcz, Department Thoracic Surgery Tumors, Nicolaus Copernicus University, Torun, Collegium Medicum, 4...
The accurate detection of genetic variants such as single substitutions (IDH1/2, TERT), chromosomal abnormalities (CDKN2A, 1p/19q deletions, and EGFR amplifications), or promoter methylations (MGMT) is critical for glioma patient management, emphasized in the World Health Organization's (WHO's) most recent classification 2021 (WHO CNS5). purpose this study was to evaluate novel innovative methods determining IDH1/2 status context WHO CNS5. Multiple biomarkers were simultaneously screened...
There is a growing interest in the genetic variation of noncoding genomic elements, including miRNAs, and several mutations miRNA genes implicated human diseases, cancer, have already been detected. However, lack dedicated analytical tools severely hampers progress this area. In study, we developed whole-miRNome sequencing (WMS), which enables targeted all (n~2000) 28 biogenesis genes. Herein, by almost 600 samples, ~300 tumor/normal pairs samples from different cancer types, identified...
Objective: The study was undertaken in order to assess the degree of impairment cardiovascular system patients with funnel chest and investigate any changes caused by surgical correction. Methods: Echocardiographic examinations systolic, diastolic ejection volume indices calculation as well pulmonary function tests were performed before surgery at medium-term follow-up on 34 who operated for pectus excavatum between 1987 1992. Results: mean age 13.4 years. There 70.6% males. Pulmonary found...
In the present study, we examined whether level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in leukocyte DNA is higher lung cancer patients compared to controls. Factors that may influence oxidative stress, such as antioxidant vitamins, were also determined. These parameters analyzed 4 groups subjects: smokers with cancer, ex-smokers healthy comparable smoking status and nonsmokers. The 8-oxodGuo mean leukocytes reached values 9.22/10(6) dGuo molecules (smokers) 11.16/10(6)...
Lung cancer is the leading cause of cancer-related death worldwide. Recent progress in lung diagnosis and treatment has been achieved due to a better understanding molecular mechanisms disease identification biomarkers that allow more specific treatments. One best known examples personalized therapy use tyrosine kinase inhibitors, such as gefitinib erlotinib, for successful non-small-cell patients selected based on EGFR mutations. Therefore, reliable detection mutations critical application...
To identify the effect of pulmonary resection on right ventricular performance and its possible contribution to mortality morbidity.Before 2 days after for primary lung cancer in 31 patients (21 males; ages 32-69 years), echocardiographic examinations ventricle were performed. Systolic, diastolic stroke volumes as well ejection fraction estimated. Right calculated using subtracting method.Right end-diastolic volume index increased significantly pneumonectomy: 80.4+/-7.2 ml/m2 versus...
The epidermal growth factor receptor (EGFR) mutation status in the tyrosine kinase domain is known to be a predictor of response gefitinib or erlotinib lung cancer; thus, non-surgical procedure tumor specimen collection critical for analysis. aim present study was analyze EGFR, KRAS and BRAF limited cytological material. To best our knowledge, this first time that quantitative scale cells percentage material were evaluated at early stages pathomorphological qualification Our results revealed...
Objective: Minute amounts of free-circulating DNA are present in plasma healthy individuals, whereas its increased concentration was observed patients with malignant tumors including non-small cell lung cancer (NSCLC). This study aimed at demonstrating the potential usefulness monitoring NSCLC for therapy effectiveness assessment throughout treatment and follow-up period. Methods: Plasma assessed 50 (stage I – IIIA) prior following radical using real-time quantitative PCR method. 10...