A5057447466- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Bacterial biofilms and quorum sensing
- Ferrocene Chemistry and Applications
- Synthesis and biological activity
- Bacteriophages and microbial interactions
- Synthesis of Tetrazole Derivatives
- Bacterial Identification and Susceptibility Testing
- Synthesis and Biological Evaluation
- Antibiotic Resistance in Bacteria
- Chemotherapy-induced organ toxicity mitigation
- Cell Image Analysis Techniques
- Microbial infections and disease research
- Kidney Stones and Urolithiasis Treatments
- Seaweed-derived Bioactive Compounds
- Molecular Sensors and Ion Detection
- Microfluidic and Bio-sensing Technologies
- Protein Interaction Studies and Fluorescence Analysis
- Analytical Chemistry and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Polysaccharides and Plant Cell Walls
- Marine Bivalve and Aquaculture Studies
- Electrochemical Analysis and Applications
- Field-Flow Fractionation Techniques
- Digital Holography and Microscopy
Central Office of Measures
2023-2025
Jan Kochanowski University
2015-2025
The physicochemical properties of metal complexes determine their potential applications as antitumor agents. In this study, the mononuclear cobalt(II) and copper(II) coordination compounds (stoichiometry: [Co(iaa)2(H2O)2]·H2O (iaa = imidazole-4-acetate anion), [Co(1-allim)6](NO3)2 (1-allim 1-allylimidazole), [Cu(iaa)2H2O] [Cu(1-allim)4(NO3)2]) ligands have been evaluated on human lung carcinoma A549 cells normal bronchial BEAS-2B cells. Designing chemical structure new agents possible...
The photophysical and sensory properties of the donor–acceptor pyrazoloquinoline derivative (PQPc) were investigated using absorption, steady-state, time-resolved fluorescence measurements. compound synthesized from commercial, readily available substrates exhibited absorptions in UV–Vis range, with a maximum longwave band around 390 nm. was 460–480 nm, depending on solvent. quantum yield between 12.87% (for n-hexane) 0.75% acetonitrile) decreased increasing solvent polarity. PET mechanism...
Half-sandwich Ru(II) complexes belong to group of biologically active metallo-compounds with promising antimicrobial and anticancer activity. Herein, we report the synthesis characterization arene ruthenium containing benzimidazole moiety, namely, [(η6-p-cymene)RuCl(bimCOO)] (1) [(η6-p-cymene)RuCl2(bim)] (2) (where bimCOO = benzimidazole-2-carboxylate bim 1-H-benzimidazole). The compounds were characterized by 1H NMR, 13C IR, UV-vis CV. Molecular structures determined SC-XRD analysis,...
Antimicrobial resistance is a growing public health concern that requires urgent action. Biofilm-associated to antimicrobials begins at the attachment phase and increases as biofilms maturate. Hence, interrupting initial binding process of bacteria surfaces essential effectively prevent biofilm-associated problems. Herein, we have evaluated antibacterial anti-biofilm activities three ruthenium complexes in different oxidation states with 2-pyridin-2-yl-1H-benzimidazole (L1 = 2,2'-PyBIm):...
The microscopic alga Coccomyxa subglobosa, collected from the Głowoniowa Nyża Cave (Tatra Mountains, Poland), is a source of fatty acids (FAs) that could be used for biodiesel production. FAs subaerial algae have unlimited availability because ubiquity in nature. Algal culture was carried out under laboratory conditions and algal biomass measured during growth phase, resulting 5 g dry weight (32% oil). acid methyl ester (FAME) profile analyzed by means gas chromatography–mass spectrometry...
The constantly growing resistance of bacteria to antibiotics and other antibacterial substances has led us an era in which alternative antimicrobial therapies are urgently required. One promising approach is target bacterial pathogens using metal complexes. Therefore, we investigated the possibility utilizing series manganese(II) complexes with heteroaromatic ligands: Alcohol, aldehyde, ketone, carboxylic acid as inhibitors for biofilm formation Pseudomonas aeruginosa. To complete mentioned...
Pseudomonas aeruginosa infection is problematic in patients with cystic fibrosis (CF). P. secretes a diversity of pigments, such as pyocyanin and pyoverdine. The aim this study was to evaluate the effects complexes nickel(II) ([Ni(iaa)2(H2O)2]·H2O (iaa = imidazole-4-acetate anion), [Ni(1-allim)6](NO3)2 (1-allim 1-allylimidazole) NiCl2 on pyoverdine production by 23 strains isolated from under growth conditions specific for CF respiratory system. antibacterial biophysical properties tested...
The aim of this study was to analyze the correlation between past bacterial infections and type chemical composition urinary stones experienced by human patients. Bacteria have been recognized contribute stones; however, role uropathogens in development specific has not extensively investigated. detection infection (eleven different species) from 83 patients made on a DNA level using polymerase chain reaction (PCR) denaturing gradient gel electrophoresis (DGGE) correlated with measured X-ray...
In this work we present an interferometric approach to quantifying the bacterial growth medium diffusion through a biofilm pretreated with tested antibacterial agent. The effect of agents on Pseudomonas aeruginosa PAO1 mature was by digital holographic microscopy and laser interferometry compared biological tests (spectrofluorimetric measurement pyocyanin pyoverdine production). It is shown that multimodal provides better determination cell eradication and/or degradation matrix forming biofilm.
As a result of drug resistance, many antimicrobial medicines become ineffective, making the infections more difficult to treat. Therefore, there is need develop new compounds with antibacterial activity. This role may be played, for example, by metal complexes carboxylic acids. study reports formation and characterization ruthenium pyridazine-3-carboxylic acid (pdz-3-COOH)-([(η
In this work we present a phase-retrieval-based approach to quantifying the diffusion of drugs through biomembranes or biofilms. So far, phenomenon was studied based on fringe orientation resulting from refractive index gradient in vicinity interface. The result is usually obtained with Mach-Zehnder interferometer an imaging system. This limits spatial resolution method and does not allow observation local changes diffusion. For reason, propose use single-shot phase retrieval by utilizing...
The study of drugs diffusion through different biological membranes constitutes an essential step in the development new pharmaceuticals. In this study, method based on monolayer cell culture CHO-K1 cells has been developed order to emulate epithelial barrier permeability studies by laser interferometry. Laser interferometry was employed for experimental analysis nickel(II) and cobalt(II) complexes with 1-allylimidazole or their chlorides’ eukaryotic monolayers. amount (mol) chlorides...