A5101725730- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mesenchymal stem cell research
- Inflammatory Myopathies and Dermatomyositis
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- IL-33, ST2, and ILC Pathways
- Eosinophilic Disorders and Syndromes
- Immune cells in cancer
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Chromatin Remodeling and Cancer
- Metabolism, Diabetes, and Cancer
- Single-cell and spatial transcriptomics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Oral and gingival health research
- Systemic Lupus Erythematosus Research
- RNA Research and Splicing
Xiangya Hospital Central South University
2016-2024
Central South University
2016-2024
University of Shanghai for Science and Technology
2023-2024
Universitätsklinikum Erlangen
2021-2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
Tongji University
2023
Jinan City People's Hospital
2023
Shandong First Medical University
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2021
Abstract Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation fibroblasts, however, may lead to fibrosis with organ dysfunction. Although several pathways capable promoting fibroblast and repair have been identified, their interplay in the context chronic fibrotic diseases remains incompletely understood. Here, we provide evidence that transforming growth factor-β (TGFβ) activates autophagy by an epigenetic mechanism amplify its profibrotic effects....
The interleukin (IL)-1 receptor accessory protein (IL1RAP) is an essential coreceptor required for signalling through the IL-1, IL-33 and IL-36 receptors. Here, we investigate antifibrotic potential of combined inhibition these cytokines by anti-IL1RAP antibody to provide a scientific background clinical development in systemic sclerosis (SSc).
Objectives Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory mechanism. This study aims to identify changes in IR profiles IIM subtypes, investigating their influence on proteins correlations with clinical features. Methods RNA sequencing liquid chromatography-tandem mass spectrometry were performed muscle tissues obtained from 174 patients 19 controls,...
Idiopathic inflammatory myopathies (IIM) are a class of autoimmune diseases with high heterogeneity that can be divided into different subtypes based on clinical manifestations and myositis-specific autoantibodies (MSAs). However, even in each IIM subtype, the symptoms prognoses patients very different. Thus, identification more potential biomarkers associated classification, symptoms, prognosis is urgently needed.
Systemic sclerosis (SSc) is characterized by fibrosis, vascular disease, and inflammation. Adenosine signaling plays a central role in fibroblast activation. We undertook this study to evaluate the therapeutic effects of adenosine depletion with PEGylated deaminase (PEG-ADA) preclinical models SSc.The PEG-ADA on inflammation, remodeling, tissue fibrosis were analyzed Fra-2 mice B10.D2→BALB/c (H-2d ) model sclerodermatous chronic graft-versus-host disease (GVHD). The confirmed vitro human...
Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate changes into transcription. Here, we used a BET inhibitor (I‐BET151) to target inflammatory tissue reduce flare severity in murine experimental model. Methods BALB/c mice were treated intraperitoneal injection or local the paw with I‐BET151, which blocks interaction...
Deregulation of the cJUN/AP-1 and hedgehog/GLI2 signaling pathways has been implicated in fibroblast activation systemic sclerosis (SSc). However, consequences their concomitant up-regulation are unknown. Here, we tested hypothesis that mutual amplification both might drive persistent activation.
Objective X-linked inhibitor of apoptosis protein (XIAP) is a multifunctional with important functions in apoptosis, cellular differentiation and cytoskeletal organisation emerging as potential target for the treatment various cancers. The aim current study was to investigate role XIAP pathogenesis systemic sclerosis (SSc). Methods expression human skin samples patients SSc chronic graft versus host disease (cGvHD) healthy individuals analysed by quantitative PCR, immunofluorescence (IF)...
Rheumatic diseases are a group of highly heterogeneous autoimmune and inflammatory disorders involving multiple systems. Dysfunction immune non-immune cells participates in the complex pathogenesis rheumatic diseases. Therefore, studies on abnormal activation cell subtypes provided specific basis for understanding diseases, which promoted accuracy disease diagnosis effectiveness various treatments. However, there was still far way to achieve individualized precision medicine as result...
Gliomas are highly malignant and invasive tumors lacking clear boundaries. Previous bioinformatics experimental analyses have indicated that F‑box leucine‑rich repeat protein 6 (FBXL6), a crucial for the cell cycle tumorigenesis, is expressed in certain types of tumors. The high expression level FBXL6 reported to promote tumor growth adversely affect patient survival. However, molecular mechanism, prognostic value drug sensitivity glioma remain unclear. To address this, present study...
Objectives Little is known on the mechanisms necessary to maintain physiological adult human skin integrity. This study aims quantitatively describe anatomical changes in systemic sclerosis (SSc)‐skin compared controls and investigate underlying mechanisms. Methods Skin morphology was histologically assessed twenty‐three SSc‐patients, eighteen fifteen patients with hypertrophic scars. Spatial WNT/β‐catenin‐activation analyzed by RNAscope immunofluorescence‐staining. Enrichment of reticular...
e14536 Background: Polybromo 1 ( PBRM1), which is required for the stability of SWI/SNF chromatin remodeling complex, often deleted or mutated in clear cell renal carcinoma (ccRCC). However, prognostic value PBRM1 ccRCC with immunotherapy was controversial and less explored other cancer types. Methods: The sequencing data clinical information patients were obtained from Cancer Genome Atlas (TCGA) cohort (n = 10967) MSKCC 387). In TCGA cohort, expression levels PD1 defined as high low using a...
Abstract Purpose Gliomas are highly malignant and invasive tumors that lack clear boundaries. Recent bioinformatics experimental analyses have indicated FBXL6, a protein crucial for the cell cycle tumorigenesis, is expressed in certain tumors. This high expression of FBXL6 thought to promote tumor growth adversely affect patient survival. However, molecular mechanism, prognostic value, drug sensitivity gliomas still remain unclear. Methods To address these gaps, we conducted an extensive...
<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, inflammation, and extensive fibrosis of the skin organs. Exosomes (EXOs) are cell-derived vesicles 30-150 nm in size that contain various mRNAs, microRNAs proteins. <h3>Objectives</h3> Here, we aimed to investigate roles EXOs SSc pathogenesis, especially angiogenesis. <h3>Methods</h3> were respectively isolated from plasma, cultured peripheral blood mononuclear cells (PBMCs) neutrophil...
e16083 Background: Gastric cancer (GC) is the fifth most incident and fourth deadliest worldwide, currently immune checkpoint inhibitors have been approved for treatment of patients with recurrent/metastatic GC. Studies reported that inactivation chromatin remodeling complex may be a promising biomarker (ICI) treatment. The aim this study was to investigate predictive value genes on response ICIs in Methods: We analyzed next-generation sequencing (NGS) data from three cohorts: Chinese cohort...