A5070794392- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Selenium in Biological Systems
- Analytical Chemistry and Chromatography
- X-ray Diffraction in Crystallography
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Crystallization and Solubility Studies
- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Inflammasome and immune disorders
- Nitric Oxide and Endothelin Effects
- Heat shock proteins research
- Animal Nutrition and Physiology
- RNA Research and Splicing
- Sulfur Compounds in Biology
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Luminescence and Fluorescent Materials
- MicroRNA in disease regulation
- Trace Elements in Health
- Respiratory Support and Mechanisms
- Ionic liquids properties and applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Northeast Petroleum University
2024-2025
Hunan Normal University
2021-2025
Hunan Provincial People's Hospital
2021-2025
Linyi University
2020-2024
Hunan University of Traditional Chinese Medicine
2023-2024
University of Bristol
2022
Shenyang Aerospace University
2022
Yunnan Normal University
2019-2021
Central South University
2014-2021
Xiangya Hospital Central South University
2014-2021
Abstract A copper‐catalyzed asymmetric aryl C−P cross‐coupling/cyclization reaction was successfully developed via dynamic kinetic transformation (DYKAT) under mild conditions. This study provides a general and simple method for the catalytic enantioselective synthesis of stable six‐, seven‐ eight‐membered P‐stereogenic phosphorus heterocycles with excellent enantioselectivities moderate to high yields. One‐pot gram‐scale P‐heterocycle from commercially available materials also accomplished...
Type 2 diabetes is an insulin-resistant state characterized by hyperinsulinemia and accelerated atherosclerosis. In vitro in vivo studies rodents have suggested that nitric oxide generation plays important role glucose transport insulin action. We determined synthase (NOS) activity skeletal muscle of 10 type diabetic (hemoglobin A1C = 6.8 ± 0.1%) 11 control subjects under basal conditions during 80 mU/m2·min euglycemic clamp performed with vastus lateralis biopsies before after 4 h insulin....
Doxorubicin (DOX) is an anthracycline drug with a wide spectrum of antineoplastic activities. However, it causes cardiac cytotoxicity, and this limits its clinical applications. MicroRNA-21 (miR-21) plays vital role in regulating cell proliferation apoptosis. While miR-21 preferentially expressed adult cardiomyocytes involved development heart disease, little known regarding biological functions responding to DOX-induced cytotoxicity. In study, the effects DOX on mouse function expression...
Abstract The Hedyotis diffusa – Scutellaria officinalis pair (HD–SB) has therapeutic effects on a variety of cancers. Our study was to explore the mechanism HD–SB in treatment hepatocellular carcinoma (HCC). A total 217 active ingredients and 1196 HCC-related targets were reserved from TCMSP SwissTarget Prediction database, we got 63 intersection GeneCards. We used Venn diagram, Cytoscape found that three core quercetin, luteolin, baicalein. PPI analysis showed TP53, CDK2, XPO1, APP....
Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used...
<title>Abstract</title> Background Current sepsis biomarkers have limitations, but mass spectrometry-based proteomics can identify patients at high risk of mortality or organ dysfunction, the molecular mechanisms pediatric sepsis, and reveal personalized therapeutic strategies, with high-risk cohorts benefiting from early accurate identification through clinical biomarkers. Methods The young mice were randomly divided into sham groups(D0), then plasma was dissected D0, day 1(D1), day3(D3)...
In this paper, an optimized structure of 4H-SiC U-shaped trench gate MOSFET (UMOSFET) with low resistance is proposed. The adds n-type region, wrapping the p+ shielding region incorporated at bottom gate. depletion formed by reduces greatly for high dopant concentration added region. This also conducts electrons downward and expands to We discussed influence width on breakdown voltage (BV) ON-resistance in paper. A reasonable size were chosen our simulation. channel inversion layer mobility...
Globally, the subsequent complications that accompany sepsis result in remarkable morbidity and mortality rates. The lung is among vulnerable organs incur sepsis-linked inflammatory storm frequently culminates into ARDS/ALI. metformin-prescribed anti-diabetic drug has been revealed with anti-inflammatory effects sepsis, but underlying mechanisms remain unclear. This study aimed to ascertain metformin's functions a young mouse model of sepsis-induced ALI.
Accurate identification of pedestrian crossing intention is great significance to the safe and efficient driving future fully automated vehicles in city. This paper focuses on recognition basis detection tracking. A large number natural sequence data pedestrians are first collected by a laser scanner HD camera, then 1980 effective samples selected. Influencing parameter sets obtained through statistical analysis. Finally, long short-term memory network with attention mechanism (AT-LSTM)...
COVID-19 is characterized by endothelial dysfunction and presumed to have long-term cardiovascular sequelae. In this cross-sectional study, we aimed explore the serum levels of biomarkers in patients who recovered from one year after hospital discharge.In clinical follow-up 345 survivors Huanggang, Hubei, 119 age gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram Doppler ultrasound lower extremities,...
Objectives Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory mechanism. This study aims to identify changes in IR profiles IIM subtypes, investigating their influence on proteins correlations with clinical features. Methods RNA sequencing liquid chromatography-tandem mass spectrometry were performed muscle tissues obtained from 174 patients 19 controls,...