A5026337187- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Mosquito-borne diseases and control
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- Peroxisome Proliferator-Activated Receptors
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Parasitic Diseases Research and Treatment
- Sodium Intake and Health
- Nutritional Studies and Diet
- Parasites and Host Interactions
- Lipid metabolism and biosynthesis
- Dermatological diseases and infestations
- Diabetes and associated disorders
- Immune cells in cancer
- Retinal Imaging and Analysis
Navamindradhiraj University
2017-2024
Vajira Hospital
2010-2023
Bridge University
2022
Bangkok Metropolitan Administration
2011
The University of Texas Health Science Center at San Antonio
2003-2010
The effect of pioglitazone (PIO) on plasma adiponectin concentration, endogenous glucose production (EGP), and hepatic fat content (HFC) was studied in 11 type 2 diabetic patients (age, 52 ± yr; body mass index, 29.6 1.1 kg/m2; HbA1c, 7.8 0.4%). HFC (magnetic resonance spectroscopy) basal concentration were quantitated before after PIO (45 mg/d) for 16 wk. Subjects received a 3-h euglycemic insulin (100 mU/m2·min) clamp combined with 3-[3H] infusion to determine rates EGP tissue...
The effect of pioglitazone on splanchnic glucose uptake (SGU), endogenous production (EGP), and hepatic fat content was studied in 14 type 2 diabetic patients (age 50 ± years, BMI 29.4 1.1 kg/m2, HbA1c 7.8 0.4%). Hepatic (magnetic resonance spectroscopy) SGU (oral load- insulin clamp technique) were quantitated before after (45 mg/day) therapy for 16 weeks. Subjects received a 7-h euglycemic (100 mU · m−2 min−1) clamp, 75-g oral load ingested 3 h starting the clamp. Following ingestion,...
To investigate the effect of a sustained (7-day) decrease in plasma free fatty acid (FFA) concentrations on insulin action and intramyocellular long-chain acyl-CoAs (LCFA-CoAs), we studied acipimox, potent inhibitor lipolysis, seven type 2 diabetic patients (age 53 ± 3 years, BMI 30.2 2.0 kg/m2, fasting glucose 8.5 0.8 mmol/l, HbA1c 7.5 0.4%). Subjects received an oral tolerance test (OGTT) 120-min euglycemic (80 mU/m2 per min) clamp with 3-[3H]glucose/vastus lateralis muscle biopsies to...
Type 2 diabetes is an insulin-resistant state characterized by hyperinsulinemia and accelerated atherosclerosis. In vitro in vivo studies rodents have suggested that nitric oxide generation plays important role glucose transport insulin action. We determined synthase (NOS) activity skeletal muscle of 10 type diabetic (hemoglobin A1C = 6.8 ± 0.1%) 11 control subjects under basal conditions during 80 mU/m2·min euglycemic clamp performed with vastus lateralis biopsies before after 4 h insulin....
The involvement of the immune system in protection and pathology natural dengue virus (DENV) has been extensively studied. However, despite studies that have referred to activation neutrophils DENV infections, exact roles remain elusive. Here, we explored phenotypic functional responses a cohort adult patients. Results indicated during an acute infection, up-regulate CD66b expression, produce more robust respiratory response as compared with convalescent or healthy individuals; this...
To investigate the effect of a sustained (7-d) decrease in plasma free fatty acid (FFA) concentration individuals genetically predisposed to develop type 2 diabetes mellitus (T2DM), we studied acipimox, potent inhibitor lipolysis, on insulin action and adipocytokine concentrations eight normal glucose-tolerant subjects (aged 40 +/- 4 yr, body mass index 26.5 0.8 kg/m(2)) with at least two first-degree relatives T2DM. Subjects received an oral glucose tolerance test (OGTT) 120 min euglycemic...
Muscle insulin resistance develops when plasma free fatty acids (FFAs) are acutely increased to supraphysiological levels (approximately 1,500-4,000 micromol/l). However, FFA >1,000 micromol/l rarely observed in humans under usual living conditions, and it is unknown whether action may be impaired during a sustained but physiological increase seen obesity type 2 diabetes mellitus (T2DM) 600-800 It also unclear normal glucose-tolerant subjects with strong family history of T2DM (FH+) would...
Lipotoxicity (increased tissue fat content) has been implicated in the development of muscle insulin resistance and type 2 diabetes mellitus (T2DM).The aim was to study effect pioglitazone on intramyocellular metabolism.Twenty-four T2DM subjects (glycosylated hemoglobin = 8.3 +/- 0.4%) participated three similar protocols before after 4 months 45 mg/d treatment: 1) 3-h euglycemic (80 mU/m(2) . min) clamp with measurement proton nuclear magnetic resonance; 2) vastus lateralis biopsy for...
BackgroundDengue infection is a global health threat. While symptomatic cases contribute to morbidity and mortality, the majority of infected people are asymptomatic but serve as an important reservoir. However, kinetics viremia in infections remains unknown.MethodsWe enrolled 279 hospital-based index quantified dengue virus (DENV) RNA at enrollment day defervescence. To identify cases, 175 household members were monitored for clinical symptoms during follow-up, blood was taken twice weekly...
Lipid oversupply plays a role in developing insulin resistance skeletal muscle, decreasing expression of nuclear-encoded mitochondrial genes, and increasing extracellular matrix remodeling. To determine if decrease plasma lipid content reverses these abnormalities, insulin-resistant subjects with family history type 2 diabetes had euglycemic clamps muscle biopsies before after acipimox treatment to suppress free fatty acids. Free acids fell from 0.584 +/- 0.041 0.252 0.053 mmol/l (P < 0.001)...
Introduction. Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control and have pleiotropic effects on kidney injury, albuminuria, vascular inflammation, especially in animal models. We evaluated the of a potent DPP4 inhibitor (gemigliptin) these processes among patients with diabetic disease (DKD). Methods. This study employed multicenter, prospective, randomized, placebo-controlled design. A total 201 participants were enrolled randomly assigned to one two groups, received...
Effective clinical management of acute dengue virus (DENV) infection relies on the timing suitable treatments during disease progression. We analyzed single-cell transcriptomic profiles peripheral blood mononuclear cell samples from two DENV patients, collected daily phase and also at convalescence. Key immune types demonstrated different dynamic responses over course infection. On day before defervescence (Day -1), we observed peak expression several prominent genes in adaptive...
Abstract Background The emergent outbreak of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has emphasized the requirement for therapeutic opportunities to overcome this pandemic. Ivermectin is an antiparasitic drug that shown effectiveness against various agents, including SARS-CoV-2. This study aimed assess efficacy ivermectin treatment compared with standard care (SOC) among people mild moderate COVID-19 symptoms. Methods In randomized,...
The aim of this study was to investigate insulin sensitivity and secretion in lean obese Asian (Thai) type 2 diabetic patients.Insulin assessed with the hyperinsulinemic euglycemic (80 mU/m(2) per min) hyperglycemic clamp technique 9 10 patients diabetes 4 nondiabetic control subjects.Obese diabetics had a lower M-value (sensitivity exogenous insulin) than (8.7 +/- 1.3 versus 16.5 1.6 mg . fat free mass kg(-1) min(-1), P < 0.001) subjects (15.9 4.0 0.05). Insulin (M-value) similar as...
The Asia-Pacific region carries a high disease burden, with over half of the global diabetic population residing in this region.Increasing evidence shows that without targeted intervention, progression from impaired glucose tolerance (IGT) to type 2 diabetes occurs more frequently Asians compared Caucasians.Furthermore, IGT is independently associated an increased risk cardiovascular disease, and should be managed as early possible.Because now major public health issue, strategies aimed at...
Abstract The objective of this study was to evaluate the efficacy and safety gemigliptin added a stable dose insulin alone or in combination with metformin patients type 2 diabetes mellitus. After two‐week run‐in period, were randomized 2:1 receive 50 mg placebo once daily as add‐on background therapy plus for 24 weeks. primary endpoint change haemoglobin A1c (HbA1c) from baseline at Week 24. Baseline characteristics similar between (n = 188) 95) groups terms HbA1c (8.1%). At 24, group...
Familial hypercholesterolemia (FH) is currently underdiagnosed and undertreated. The establishment of a FH registry could facilitate deeper understanding this disease. We described the clinical characteristics subjects with from Thai Registry, compared our data regional global data, identified gaps in care these subjects.A multicenter, nationwide prospective was established Thailand. Our were those European Atherosclerosis Society-FH Studies Collaboration. Multiple logistic regression...
<title>Abstract</title> A causal relationship between salt intake and hypertension, stroke, kidney disease has been established. However, whether reduced leads to lower blood pressure intensely debated. In this prospective, open-label, randomized controlled trial, we examined the impact of low-salt diet on pressure, renal function, other metabolic parameters. Herein, 194 patients with chronic (CKD) stage 1–3 were into (intervention) control groups. The intervention group was provided a (1.5...
A causal relationship exists between salt intake and hypertension, stroke, kidney disease. However, whether or not reduced slows progression of renal diseases has been intensely debated.
An 85-year old Thai woman was admitted to the hospital for dyspnea. Her ECG showed complete atrioventricular (AV) block. laboratory data upon admission revealed low serum thyroxine level and elevated thyrotropin level. Levothyroxine started, AV conduction block supported by a temporary pacemaker. At end of second week, her free T4 fell within normal range. The pacemaker subsequently removed. She discharged without permanent pacing. This case demonstrated that hypothyroidism can cause...
Abstract The emergent outbreak of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has emphasized the requirement for therapeutic opportunities to overcome this pandemic. Ivermectin is an antiparasitic drug that shown be effective against various agents, including SARS-CoV-2, and under extensive research in clinical trials. In randomized, double-blind, placebo-controlled trial among adult hospitalized patients with mild-to-moderate COVID-19, 72...