A5101924482- Gut microbiota and health
- Polysaccharides and Plant Cell Walls
- Biochemical Analysis and Sensing Techniques
- Long-Term Effects of COVID-19
- Ion channel regulation and function
- COVID-19 Clinical Research Studies
- Ion Transport and Channel Regulation
- Cystic Fibrosis Research Advances
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Medicinal Plants and Neuroprotection
- Bone Metabolism and Diseases
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- SARS-CoV-2 and COVID-19 Research
- Biological and pharmacological studies of plants
- Phytoestrogen effects and research
- Plant-derived Lignans Synthesis and Bioactivity
- Synthesis and Biological Evaluation
Jilin Agricultural University
2006-2025
Shenyang Pharmaceutical University
2024
State Key Laboratory of Microbial Technology
2024
Shandong University
2024
Hunan Normal University
2020-2022
Hunan Provincial People's Hospital
2020-2022
Liaoning Normal University
2013-2017
Kansas State University
2010-2014
Abstract In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data examined the expression endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels fractalkine, vascular molecule-1 (VCAM-1), intercellular molecule 1 (ICAM-1), protein-1 (VAP-1) were elevated with mild disease, dramatically severe cases, decreased convalescence phase. We conclude increased is related to disease severity may contribute...
Secretory diarrhea remains a global health burden and causes major mortality in children. There have been some focuses on antidiarrheal therapies that may reduce fluid losses intestinal motility diarrheal diseases. In the present study, we identified shikonin as an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. The IC50 value was 6.5 μM. Short-circuit current measurements demonstrated inhibited Eact-induced Cl dose-dependent manner, with 1.5...
COVID-19 is characterized by endothelial dysfunction and presumed to have long-term cardiovascular sequelae. In this cross-sectional study, we aimed explore the serum levels of biomarkers in patients who recovered from one year after hospital discharge.In clinical follow-up 345 survivors Huanggang, Hubei, 119 age gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram Doppler ultrasound lower extremities,...
Epithelial chloride channels provide the pathways for fluid secretion in intestine. Cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated (CaCCs) are main luminal membrane of enterocytes. These proteins play important roles many physiological processes. In this study, we have identified a flavonoid quercetin as modulator CaCC channel activity. Fluorescence quenching assay showed that activated Clˉ transport dose-dependent manner, with EC50 ~37 µM. Short-circuit...
Thrombotic diseases have become a global burden due to morbidity, mortality, and disability. Traditional Chinese medicine has been proven effective in removing blood stasis promoting circulation, but the exact mechanisms remain unclear. Plasminogen activator inhibitor‐1 (PAI‐1) is natural inhibitor of tissue‐type urokinase‐type plasminogen activators. In this study, we screened four fractions Resina Draconis (a traditional medicine) extract for PAI‐1 inhibitory activity. Bioactivity‐guided...
Inflammatory bowel disease is a group of chronic, incurable inflammatory disorders the gastrointestinal tract that cause severe diarrhoea, intestinal inflammation, pain, fatigue and weight loss. In this study, we first developed model Citrobacter rodentium -induced colitis then evaluated protective effects selected probiotics on inflammation. The results showed administration combination including Lactobacillus rhamnosus ATCC 53103, acidophilus 4356 plantarum A significantly increased...
Phytochemicals have received much recent attention in cancer prevention through simultaneous targeting multiple pathways the disease progression. Here we determined that wolfberry phytochemicals was chemopreventive on leukemic Jurkat cell. The water soluble fractions (i.e., phytochemicals) were enriched carbohydrates (73.4 ± 4.5 % (w/w)), polyphenolics (1555 112 mg quercetin equivalent/100 g freeze dry powder, including 213 rutin/100 powder), and had enhanced antioxidant activity (7771 207...
Deer bone is rich in proteins and free amino acids, offering high nutritional value benefits such as strengthening bones antioxidant properties. However, the development utilization of deer resources are limited, safety evaluation health foods incomplete.
Diarrhea with physical weakness is a highly prevalent symptom in patients inflammatory bowel disease. Based on the dextran sodium sulfate (DSS) -induced mouse ulcerative colitis model, present study was undertaken to investigate effect and possible mechanism of Hericium caput-medusae (Bull.: Fr.) Pers. fermentation concentrate polysaccharide (HFP) diarrhea mice. HFP alleviated DSS-induced symptoms mice, including elevated body weight, increased colonic length as well mucus layer thickness,...
Plant lignans are diphenolic compounds widely present in vegetables, fruits, and grains. These have been demonstrated to protective effect against cancer, hypertension diabetes. In the study, we showed that two lignan compounds, kobusin eudesmin, isolated from Magnoliae Flos, could modulate intestinal chloride transport mediated by cystic fibrosis transmembrane conductance regulator (CFTR) calcium-activated channels (CaCCs). The activated CFTR channel function both FRT cells HT-29 cells....
<p>Inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and Ca<sup>2+</sup>-activated Cl<sup>-</sup> channel (CaCC) represents an attractive approach for the treatment secretory diarrhea. The aim study is to investigate molecular basis anti-diarrheal effect traditional Chinese herbal medicine <em>Bistortae rhizoma</em>. Fluorescence quenching assay indicated that 40% methanol /water fraction (D5) dose-dependently inhibited both...
Abstract Gut microbiota dysbiosis has been implicated in rheumatoid arthritis (RA) and influences disease progression. Although molecular culture‐independent studies revealed RA patients harbored a core microbiome had characteristic bacterial species, the lack of cultured strains limited investigations on their functions. This study aimed to establish an RA‐originated gut microbial biobank (RAGMB) that covers further correlates validates species clinically used diagnostic inflammation immune...