A5056032674- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Neonatal Respiratory Health Research
- Renal and related cancers
- Neuroscience of respiration and sleep
- Genetic and Kidney Cyst Diseases
- Fatty Acid Research and Health
- Polyamine Metabolism and Applications
- Nutrition, Genetics, and Disease
- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- Pulmonary Hypertension Research and Treatments
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Pediatric health and respiratory diseases
- Urological Disorders and Treatments
- Sulfur Compounds in Biology
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Respiratory and Cough-Related Research
- Nutrition and Health in Aging
- Phytoestrogen effects and research
Wheaton College - Illinois
2009-2022
East Carolina University
2017-2022
Kansas State University
2000-2015
Framingham State University
2007
University of Kentucky
1994
Pennsylvania State University
1993-1994
Weight control by exercise and dietary calorie restriction (DCR) has been associated with reduced cancer risk, but the underlying mechanisms are not well understood. This study was designed to compare effects of weight loss increasing physical activity or decreasing intake on tumor promoter-induced Ras-MAPK PI3K-Akt pathways. SENCAR mice were randomly assigned one following five groups: ad libitum-fed sedentary control, (AL+Exe), pair-fed at amount as controls (PF+Exe), 20% DCR, DCR plus...
Bleomycin, a widely used antineoplastic agent, has been associated with severe pulmonary toxicity, primarily fibrosis. Previous work shown reduction in bleomycin-induced lung pathology by long-chain omega-3 fatty acids. Treatment short-chain acids, α-linolenic acid, found dietary flaxseed oil may also reduce fibrosis, as previously evidenced the kidney. To test this hypothesis, 72 rats were divided between diets receiving either 15% (w/w) or corn (control). These groups further to receive...
Cancer prevention by weight control via dietary calorie restriction (DCR) and/or exercise has been demonstrated in animal models. To understand the underlying mechanisms, we compared phorbol ester (TPA)-induced gene expression profiles DCR- or exercise-treated mouse skin tissues. SENCAR mice were randomly assigned to one of following groups: ad libitum-fed sedentary control, (AE), but pair-fed at amount (PE), and 20% DCR. After 10 weeks, both body fat composition significantly decreased DCR...
Cux1 is a homeodomain protein involved in cell cycle regulation and kidney development. represses the cyclin kinase inhibitor p27 during early development, promoting proliferation nephrogenic zone. Promoter reporter analysis of revealed that concentration dependent manner, immunoprecipitation showed interacts with co-repressor Grg4 histone deacetylases HDAC1 HDAC3. Chromatin (ChIP) identified interaction Cux1, Grg4, HDAC1, HDAC3 at two different sites promoter. To determine whether there was...
The purpose of this study was to determine the responsiveness alveolar type II cells dietary fish oil and consequent effects on lung surfactant. Rats were fed a corn or diet for four weeks. Dietary n-3 fatty acids readily incorporated into cell phospholipids as indicated by higher levels eicosapentaenoic acid (2.77 +/- 0.10%) docosahexaenoic (1.63 in group receiving diet. elevated accompanied concomitant reduction arachidonic linoleic acid. Neither nor triacylglycerols. Feeding containing...
Monocrotaline (MCT), a pyrrolizidine alkaloid extracted from the shrub Crotalaria spectabilis, induces in lungs of many mammalian species severe hypertension and fibrosis. Previous work with MCT-induced lung disease rats has shown that some steps to progressive fibrosis can be interrupted or decreased by intervention retinoic acid (RA) angiotensin converting enzyme inhibitor, captopril. This report emphasizes pathology cytokines present MCT model 8 treatment groups, six per group: (1)...
We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation tracheal precancerous lesions. However, underlying mechanism cancer risk induced by vitamin A deficiency unclear. The purpose this study was to determine whether smoke-induced depletion related changes lung risk-related molecular markers.We investigated roles receptors (RARs) as well other biomarkers for potential rats exposed smoke. Twenty-four male...
Older adults frequently report use of vitamin and mineral (VM) supplements, although the impact supplements on dietary adequacy remains largely unknown. The purpose current study was to evaluate micronutrient intakes older with emphasis identifying nutrients most improved by VM likely remain inadequate, consumed in excess. Community-based volunteers were recruited from senior centers completed a questionnaire querying demographic data, health status, supplement use. Participants (n = 263)...
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic hereditary disorders in humans characterized by fluid-filled cysts, primarily kidneys. Cux1, a cell cycle regulatory gene highly expressed during development, elevated cyst-lining cells Pkd1 mutant mice, and human ADPKD cells. However, forced expression Cux1 insufficient to induce cystic transgenic mice or rapid cyst formation after cilia disruption kidneys adult mice. Here we report double mouse model...
Abstract Arachidonic acid and its leukotriene metabolites have been shown to stimulate surfactant secretion by alveolar type II cells. The present study was undertaken determine the effects of various unsaturated fatty acids, including eicosapentaenoic acid, on secretion. Surfactant expressed as percent [ 3 H]choline‐derived phospholipids released into culture medium pneumocytes adult rats. Consistent with earlier findings, arachidonic stimulated in a concentration‐dependent fashion (3.5–21...
CUX1 is a transcriptional repressor gene in the network controlling G1‐S phase transition. It represses expression of cyclin kinase (CK1) inhibitors p21 and p27. Transgenic mice constitutively expressing develop multiorgan damage consequent to aberrant p27 kidneys (polycystic), testes (diminished spermatogenesis), liver (fibrosis). These also present severe pulmonary inflammation, vasculitis, bronchiolitis, bronchiectasis, fibrosis. This study relates induced heart expression. H&E...
Research has indicated that excessive vitamin A can have deleterious impacts on bone. Retinoic acid (RA), the most active metabolite of A, been tested in clinical trials for treatment lung cancer and emphysema. These are not measuring Bone Mineral Content (BMC) or Density (BMD). In this study, we used an animal model to determine potential effects all-trans RA bone mass when as a means protect against treat cigarette smoke-induced injuries, also evaluate BMC early indicator osteoporosis...