A5041378395- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Kruppel-like factors research
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Wnt/β-catenin signaling in development and cancer
- Cardiac Fibrosis and Remodeling
- Metastasis and carcinoma case studies
Zhejiang Provincial People's Hospital
2014-2024
Hangzhou Medical College
2017-2024
Zhejiang Hospital
2009-2021
Changhai Hospital
2019
Fudan University
2019
Second Military Medical University
2019
Hebei North University
2008-2013
Wenzhou Medical University
2008
Baylor College of Medicine
2008
Zhejiang Provincial Natural Science Foundation
2008
The present study investigated the clinical significance of secreted protein, acidic and rich in cysteine (SPARC), development progression gastric cancer.Immunohistochemistry was used to analyze SPARC, integrin beta1, matrix metalloproteinase (MMP)-2 expression 436 clinicopathologically characterized cancer cases.SPARC, MMP-2 protein levels were upregulated lesions compared with adjacent noncancerous tissues. SPARC detected 334 human cases highly expressed 239 tumors. We also found a...
Abstract Background Recent studies have shown that miR-199a-5p plays opposite roles in cancer initiation and progression of different types, acting as oncogene for some types but tumor suppressor gene others. However, the role molecular mechanism gastric are largely unknown. Methods In this study, expression level was first analyzed by qPCRand then validated 103 patients situ hybridization (ISH). Gastric cell lines were transfected with inhibitor mimic, underwent vitro transwell assays....
Abstract Background The metalloproteinase domain‐containing protein 10 (ADAM 10) has been implicated in the development and progression of gastric cancer. Methods Expression ADAM C‐erbB‐2 were examined immunochemically 436 clinicopathologically characterized cancer cases. Results Protein levels up‐regulated lesions compared with adjacent non‐cancerous tissues. Positive expression correlated age, size tumor, location depth invasion, vessel lymph node, distant metastasis TNM stage, also...
Increased expression of galectin-1 (Gal-1) in carcinoma-associated fibroblasts (CAFs) has been reported to correlate with progression and prognosis many cancers. However, rarely have reports sought determine whether high Gal-1 CAFs gastric cancer is involved the tumor process, specific mechanism by which it promotes evolution still unknown. In this study, we cultured CAFs, showed strong Gal-1, established a co-culture system cells. Specific siRNA vitro migration invasion assays were used...
Abstract: MicroRNA (miR)-145-5p has been reported to function as a suppressor of cancer and plays an important role in invasiveness. Epithelial–mesenchymal transition (EMT) is process invasion migration. However, the involvement miR-145-5p EMT human gastric (GC) remains unclear. In this study, we aimed investigate molecular mechanisms by which regulates GC We used quantitative real-time polymerase chain reaction expression level matched normal tissues. The effects on cell migration abilities...
Abstract Objectives Evidence from previous documents points to the involvement of Keratin 15 (KRT15) gene in modulation signaling networks governing cancer cell death, survival, proliferation, migration, invasion, and metastasis. Nonetheless, its relevance pan-cancer studies precise molecular mechanisms involved lung remain poorly understood. To comprehensively investigate clinical KRT15 human a diverse array cancers. Methods A comprehensive investigation tumors was conducted. In light this,...
To study clinical characteristics and management of patients with early severe acute pancreatitis (ESAP).Data 297 (SAP) admitted to our hospital within 72 h after onset symptoms from January 1991 June 2003 were reviewed for the occurrence development (ESAP). ESAP was defined as presence organ dysfunction symptoms. Sixty-nine had ESAP, 228 without SAP. The characteristics, incidence during hospitalization prognosis between SAP compared.Impairment degree pancreas (Balthazar CT class) in more...
Abundant macrophage infiltration and increased expression of coagulation factors have been observed in cancer patients. The aim the present study was to determine how interaction between activated monocytes/macrophages contributes gastric (GC) cell migration invasion. We assessed cytokine/chemokine production coagulation-factor-treated macrophages by ELISA. effects tumor-associated (TAM) on GC invasion were determined vitro assay. In addition, we used an co-culture system cells/TAM treated...
Recent studies have shown that overexpression of regenerating gene family member 4 (REG4) is associated with the initiation and progression pancreatic cancer. In our study, we explored role REG4 in invasion Real-time PCR Western blot analysis were used to determine expression cancer cell lines. An MTT assay was carried out test effect on growth cells. The involvement examined by Transwell assay. Two MMPs, MMP-7 MMP-9, identified from a pool candidate genes as being related REG4-induced...
L1 cell adhesion molecule (L1CAM) and epithelial (EPCAM) have been implicated in the development progression of gastric cancer. The present study investigated clinical significance L1CAM EPCAM development, prognosis cancer.Expression were examined immunochemically 601 clinicopathologically characterized cancer cases.L1CAM protein was detected 23.9% human non-tumor mucosa samples. All samples expressed at low levels. High expression 163 (27.1%) tumors. Expression correlated with age, tumor...
Background and Objectives miR-301a is significantly overexpressed in many cancers. However, its expression biological role gastric cancer remain poorly understood. We investigated microRNA-301a (miR-301a) determined effects on cell behavior clinical significance the development progression of cancer. Methods tumors lines by reverse transcription-polymerase chain reaction. The clone formation, migration, invasion HGC-27 SGC-7901 cells were detected following transfection an inhibitor. a...
In chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. To treat COPD, it is crucial to repair damaged lung tissue regenerate lost alveoli. Type II epithelial cells (AECII) play a vital role in maintaining repair, amniotic fluid-derived mesenchymal stromal (AFMSCs) possess characteristics regular cells. However, remains untested whether transplantation rat AFMSCs (rAFMSCs) might alleviate injury...
Increased expression of HOXB7 has been reported to correlate with the progression in many cancers. However, specific mechanism by which it promotes evolution gastric cancer (GC) is poorly understood.In this study, we sought investigate role GC assessing patient tissue and its correlation clinical characteristics. We found that tissues showed increased was significantly associated Lauren classification, invasion depth, lymphatic metastasis poor prognosis, could serve as an independent...
Activation of the Toll-like receptor 4 (TLR4) by bacterial endotoxins in macrophages plays a crucial role pathogenesis sepsis. However, mechanism underlying TLR4 activation is still not fully understood. Here, we reveal that upon lipopolysaccharide (LPS) stimulation, lysine acetyltransferase CBP recruited to signalosome complex leading increased acetylation TIR domains signalosome. Acetylation significantly enhances signaling via NF-κB rather than IRF3 pathways. Induction responsible for...
In chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. Type II epithelial cells (AECII) play a vital role in maintaining homeostasis lung tissue repair. Sirtuin 1 (SIRT1), NAD+-dependent histone deacetylase, regulates many pathophysiological processes including inflammation, apoptosis, cellular senescence stress resistance. The main aim this study was to investigate whether SRT1720,...
analysis demonstrated that the mean survival time and 5-year rate were lower in cases with low expressions of syndecan-1 E-cadherin high expression integrin β3 (P < 0.01, all cases).COX multivariate showed level could be an independent prognostic index gastric carcinoma 0.01), whereas not indexes > 0.05, P 0.05 respectively). CONCLUSION:The are significantly correlated invasion metastasis carcinoma, they highly each other.Therefore may serve as important markers carcinoma.
Abstract To investigate matrix metalloproteinase‐9 (MMP‐9) mRNA and vascular endothelial growth factor (VEGF) protein expression in gastric carcinoma its correlation with microvascular density, growth‐pattern, invasion, metastasis, prognosis. In situ hybridization of MMP‐9 immunohistochemistry VEGF CD34 proteins were performed on surgical specimens cancers from 118 patients compared 20 nonmalignant mucosae. Their relationships to pathological parameters survival times determined by...