A5073090575- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Liver physiology and pathology
- Oral Health Pathology and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune and Inflammatory Disorders Research
- Multiple Myeloma Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Ubiquitin and proteasome pathways
- Pancreatic function and diabetes
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Psoriasis: Treatment and Pathogenesis
- Vasculitis and related conditions
- Protein Degradation and Inhibitors
- S100 Proteins and Annexins
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Mast cells and histamine
Universitätsklinikum Erlangen
2019-2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2023
Rockefeller University
2023
University of Calabria
2001
Abstract Tumors consist of cancer cells and a network non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, emerging as immune modulators. Neutrophils release histone-bound nuclear DNA cytotoxic granules extracellular traps (NET). Here we show that CAFs induce NET formation within the tumor systemically in blood bone marrow. These tumor-induced NETs (t-NETs) driven by ROS-mediated pathway dependent on CAF-derived Amyloid β, peptide implicated both...
Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) study the function of these cells in vivo. Here, we revisited effects Clo-Lip together with genetic models MoPh deficiency, revealing that exert their anti-inflammatory independent MoPh. Notably, not only but also polymorphonuclear neutrophils (PMN) ingested vivo, which resulted functional arrest. Adoptive transfer PMN, MoPh, reversed treatment, indicating stunning PMN rather than depletion accounts...
Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition NET reduces pathology in multiple inflammatory models, indicating that NETs are potential therapeutic targets. Here, we demonstrate using a preclinical basket approach our anti-citrullinated protein antibody (tACPA) has broad potential. Treatment tACPA prevents symptoms various mouse models...
Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-allelic mutations IL36RN, the genetic cause not known most cases. To identify characterize new pathways involved pathogenesis GPP, we performed whole-exome sequencing 31 with GPP demonstrated effects MPO encoding enzyme myeloperoxidase (MPO). We discovered eight...
The phagocyte NADPH oxidase (the NOX2 complex) generates superoxide, the precursor to reactive oxygen species (ROS). ROS possess both antimicrobial and immunoregulatory function. Inactivating mutations in alleles of complex cause chronic granulomatous disease (CGD), characterized by an enhanced susceptibility infections autoimmune diseases such as Systemic lupus erythematosus (SLE). latter is insufficient removal dead cells, resulting response against components cell's nucleus when...
Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate changes into transcription. Here, we used a BET inhibitor (I‐BET151) to target inflammatory tissue reduce flare severity in murine experimental model. Methods BALB/c mice were treated intraperitoneal injection or local the paw with I‐BET151, which blocks interaction...
Bioreactors for liver assist tested on small animal models are generally scaled-up to treat humans by increasing their size host a given cell mass. In this process, function in different culture devices is often established based the metabolite concentration difference between bioreactor inlet and outlet irrespective of how matter distributes bioreactor. paper, we report our investigation aimed at establishing whether design operating conditions influence distribution two bioreactors...
Since publication, it was brought to our attention that the Materials and methods section incomplete did not include information on origin, preparation, handling of clodronate liposomes