A5027675251- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders
- Dermatology and Skin Diseases
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Chemokine receptors and signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
Universitätsklinikum Erlangen
2020-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2024
Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-allelic mutations IL36RN, the genetic cause not known most cases. To identify characterize new pathways involved pathogenesis GPP, we performed whole-exome sequencing 31 with GPP demonstrated effects MPO encoding enzyme myeloperoxidase (MPO). We discovered eight...
Macrophages are one of the key mediators therapeutic effects exerted by monoclonal antibodies, such as anti-CD19 antibody tafasitamab, approved in combination with lenalidomide for treatment relapsed or refractory (r/r) diffuse large B cell lymphoma (DLBCL). However, antibody-dependent cellular phagocytosis (ADCP) tumor microenvironment can be counteracted increased expression inhibitory receptor SIRPα on macrophages and its ligand, immune checkpoint molecule CD47 cells. The aim this study...
Generalized pustular psoriasis is a severe psoriatic subtype characterized by epidermal neutrophil infiltration. Although variants in IL36RN and MPO have been shown to affect immune cells, systematic analysis of neutrophils PBMC subsets their differential gene expression dependent on genotypes was not performed yet. We assessed the transcriptomes MPO-deficient patients using single-cell RNA sequencing PBMCs stable disease state. Cell-type annotation multimodal reference mapping...