A5075333464- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Viral-associated cancers and disorders
- Biosimilars and Bioanalytical Methods
- Multiple Myeloma Research and Treatments
- Advanced Nanomaterials in Catalysis
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
Universitätsklinikum Erlangen
2015-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2025
Ludwig-Maximilians-Universität München
2024-2025
Centro de Investigación del Cáncer
2025
Cancer Research Center
2024-2025
Universitätsklinikum Würzburg
2024
Huawei German Research Center
2023-2024
Comprehensive Cancer Center Erlangen
2021-2023
Beijing Hospital
2023
Second Affiliated Hospital of Guangzhou Medical University
2023
Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger in COVID-19 are incompletely understood.
Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these through deep depletion of B cells is a potential strategy achieving sustained drug-free remission.
Abstract Neutrophil extracellular traps (NETs) are structures, composed of nuclear DNA and various proteins released from neutrophils. Evidence is growing that NETs exert manifold functions in infection, immunity cancer. Recently, have been detected colorectal cancer (CRC) tissues, but their association with disease progression putative functional impact on tumourigenesis remained elusive. Using high‐resolution stimulated emission depletion (STED) microscopy, we showed citrullinated histone...
Prolonged cytopenias after chimeric antigen receptor (CAR) T cell therapy are a significant clinical problem and the underlying pathophysiology remains poorly understood. Here, we investigated how expansion dynamics serum proteomics affect neutrophil recovery phenotypes CD19-directed CAR therapy. Survival favored patients with "intermittent" (e.g., recurrent dips) compared to either "quick" or "aplastic" recovery. While intermittent displayed increased expansion, aplastic exhibited an...
Chimeric antigen receptor (CAR) T cells targeting CD19+ B have demonstrated efficacy in refractory systemic lupus erythematosus (SLE). Although initial clinical data suggest that anti-CD19 CAR cell therapy is well tolerated and highly effective, the immunologic consequences of SLE patients remain unclear. We profiled serum six prior to 3 months following infusion. Three post infusion, inflammatory cytokines IL-6 TNFα decreased patient sera. This was accompanied by elevations IL-7 BAFF....
CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has shown remarkable outcomes in patients with systemic lupus erythematosus. The effects of CAR T cells on organ manifestations sclerosis have yet to be characterised. B a central role the pathogenesis sclerosis. We present detailed analysis Six severe diffuse an insufficient response at least two treatments were consecutively recruited Department Internal Medicine 3, University Hospital Erlangen (Erlangen, Germany) receive...
Abstract Purpose: Cytokine-engineering of chimeric antigen receptor-redirected T cells (CAR cells) is a promising principle to overcome the limited activity canonical CAR against solid cancers. Experimental Design: We developed an investigational medicinal product, GD2IL18CART, consisting directed ganglioside GD2 with CAR-inducible IL18 enhance their activation response and cytolytic effector functions in tumor microenvironment. To allow stratification patients according expression, we...
Despite revolutionary efficacy of CD19-CAR-T cell therapy (CAR-T) in aggressive B lymphoma, many patients still relapse mostly early. In early failure, distinct drugs support CAR-T which makes reliable and prediction imminent relapse/refractoriness critical. A complete metabolic remission (CR) on Fluor-18-Deoxyglucose (FDG) Positron-Emission-Computed Tomography (PET) 30 days after (PET30) strongly predicts progression-free survival (PFS), but fails a relevant proportion patients. We aimed to...
Adoptive transfer of third-party mesenchymal stromal cells (MSCs) has emerged as a promising tool for the treatment steroid-refractory graft-versus-host disease (GVHD). Despite numerous in vitro studies and preclinical models, little is known about their effects on patients' immune system. We assessed alterations T-cell, B-cell, natural killer cell, dendritic monocytic compartments GVHD patients 30, 90, 180 days after MSC (n = 6) or placebo 5) infusion, respectively. Infused MSCs were...
Acute myeloid leukemia (AML) is the most common acute amongst adults with a 5-year overall survival lower than 30%. Emerging evidence suggest that immune alterations favor leukemogenesis and/or AML relapse thereby negatively impacting disease outcome. Over last years derived suppressor cells (MDSCs) have been gaining momentum in field of cancer research. MDSCs are heterogeneous cell population morphologically resembling either monocytes or granulocytes and sharing some key features including...
Cellular secretion of proteins into the extracellular environment is an essential mediator critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. Here, we report a novel methodology that allows for real-time detection imaging single unlabeled are secreted from individual living cells. This accomplished via interferometric scattered light (iSCAT) demonstrated with Laz388 cells, Epstein–Barr virus (EBV)-transformed...
The bone marrow niche has a pivotal role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the microenvironment. Myeloma-associated macrophages (MAM) are M2 like. They provide nurturing signals cells promote immune escape. Reprogramming M2-like toward tumoricidal M1 phenotype represents an intriguing therapeutic strategy. This especially interesting view successful use mAbs against cells, as these therapies hold...
Since December 2019, Coronavirus disease-19 (COVID-19) has spread rapidly throughout the world, leading to a global effort develop vaccines and treatments. Despite extensive progress, there remains need for treatments bolster immune responses in infected immunocompromised individuals, such as cancer patients who recently underwent haematopoietic stem cell transplantation. Immunological protection against COVID-19 is mediated by both short-lived neutralizing antibodies long-lasting...