A5039113386- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Health and Disease Prevention
- CAR-T cell therapy research
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Dermatology and Skin Diseases
- Metabolism, Diabetes, and Cancer
- Urticaria and Related Conditions
- SARS-CoV-2 and COVID-19 Research
- Psoriasis: Treatment and Pathogenesis
- Bone and Joint Diseases
- Heart Rate Variability and Autonomic Control
- Viral Infectious Diseases and Gene Expression in Insects
- Cutaneous lymphoproliferative disorders research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Autoimmune Bullous Skin Diseases
- Sexual function and dysfunction studies
- Orthopedic Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
- Pulmonary Hypertension Research and Treatments
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
Universitätsklinikum Erlangen
2022-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023-2025
Charité - Universitätsmedizin Berlin
2025
Bayer (Germany)
2025
Center for Rheumatology
2024
Aristotle University of Thessaloniki
2019-2023
University of Batna 1
2023
Hippocration General Hospital
2022
AHEPA University Hospital
2022
Interbalkan Medical Center
2022
Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these through deep depletion of B cells is a potential strategy achieving sustained drug-free remission.
KYV-101 is an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy under investigation for patients with B-cell driven autoimmune diseases. Hu19-CD828Z a fully human CAR designed and demonstrated to have favorable clinical safety profile. Since T cells target kill B in both circulation tissues, the treatment offers great potential depleting autoreactive cells. Demonstrate that manufactured from cryopreserved leukaphereses systemic lupus erythematosus (SLE) exhibit CAR-mediated...
Objectives: Sodium-glucose co-transporter 2 (SGLT-2) inhibitors reduce the incidence of heart failure and death in patients with type-2 diabetes mellitus. Arterial stiffness is a prominent risk factor for overall mortality. The aim this study was to evaluate effects dapagliflozin on ambulatory brachial central blood pressure (BP) levels arterial parameters Methods: This double-blind, randomized, placebo-controlled clinical trial including 85 adult mellitus monotherapy or combination therapy...
Nail psoriasis occurs in about every second patient. Both, finger and toe nails can be affected also severely destroyed. Furthermore, nail is associated with a more severe course of the disease development psoriatic arthritis. User independent quantification psoriasis, however, challenging due to heterogeneous involvement matrix bed. For this purpose, severity index (NAPSI) has been developed. Experts grade pathological changes each patient leading maximum score 80 for all hands. Application...
Rheumatoid arthritis (RA) is characterized by erosive joint damage, deterioration of bone mass, and biomechanics. Preclinical evidence suggests a beneficial effect Janus kinase inhibition (JAKi) on properties, but clinical data are scarce to date. In this study, we evaluated the JAKi through baricitinib (BARI) 1) volumetric mineral density (vBMD), microstructure, biomechanics, erosion repair 2) synovial inflammation in RA patients.Prospective, single-arm, interventional, open-label,...
Objectives Although patients with immune-mediated inflammatory diseases (IMID) are thought to be more susceptible viral infections, it is unclear whether their presentation differs between IMID and healthy controls. This study aimed investigate the symptom pattern of common infections in compare controls without IMIDs. Design A cross-sectional conducted 1 February 30 April 2020, using a questionnaire. Setting Seven tertiary regional care centers Germany, which specialised (namely,...
Prescribable digital health applications (DiGAs) present scalable solutions to improve patient self-management in rheumatology, however real-world evidence is scarce. Therefore, we aimed assess the effectiveness, usage, and usability of DiGAs prescribed by rheumatologists, as well satisfaction. The DiGAReal registry includes adult patients with rheumatic conditions who received a DiGA prescription. Data at baseline (T0) 3-month follow-up (T1) were collected through electronic questionnaires....
Journal Article Accepted manuscript Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis rheumatoid arthritis Get access Fredrik N Albach, Albach Department of Rheumatology Clinical Immunology, Charité - Universitätsmedizin Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ioanna Minopoulou, Minopoulou Artur Wilhelm, Wilhelm GermanyDeutsches Rheuma-Forschungszentrum Robert Biesen, Biesen...
Objective To improve and validate a convolutional neural network (CNN)-based model for the automated scoring of nail psoriasis severity using modified Nail Psoriasis Severity Index (mNAPSI) with adequate accuracy across all classes without dependency on standardized conditions. Methods Patients (PsO), psoriatic arthritis (PsA), non-psoriatic controls including healthy individuals patients rheumatoid were included training, while validation utilized an independent cohort patients. photographs...
Background: The accruing evidence about the efficacy of anti-IL-1 agents in Familial Mediterranean Fever (FMF) patients led to their widespread off-label use. Therefore, identifying precise indications and clinical characteristics IL-1i-warranting are important. This study investigated treatment with FMF requiring interleukin 1 inhibition therapy (IL-1i). Methods: Hospital records attending a tertiary care center at Department Rheumatology, University Health Sciences, Basaksehir Cam Sakura...
Objectives To assess the impact of low to moderate biomechanical stress on entheses in patients with psoriasis and psoriatic arthritis (PsA). Methods We conducted a prospective interventional study cohort PsA who underwent 60 min badminton training session. Pain assessment by Visual Analogue Scale (VAS), physical examination 29 (SPARCC, LEI, MASES) bilateral ultrasound at lateral humeral epicondyle, inferior patellar pole Achilles tendon were performed before after training. Ultrasound...
Introduction: To explore the incidence of pro-arrhythmic effects such as corrected QT interval (QTc) prolongation, arrhythmic events and myocardial injury azithromycin administered for treatment COVID-19. Material Methods: We searched PubMed, Cochrane Library Web Science databases from inception to 18 January 2021, well medRχiv preprint database 1 August 2020 studies exploring cardiotoxicity azithromycin, with or without concomitant use hydroxychloroquine, in context performed a random...