A5033815543- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Musculoskeletal synovial abnormalities and treatments
- Gout, Hyperuricemia, Uric Acid
- Mobile Health and mHealth Applications
- Musculoskeletal Disorders and Rehabilitation
- Biosimilars and Bioanalytical Methods
- T-cell and B-cell Immunology
- Social Media in Health Education
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Orthopedic Surgery and Rehabilitation
- HER2/EGFR in Cancer Research
Paracelsus Medical University
2023-2025
Universitätsklinikum Erlangen
2016-2025
Nuremberg Hospital
2021-2025
Paracelsus Medizinische Privatuniversität
2021-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Women's College Hospital
2023
University of Waterloo
2023
Sozialstiftung Bamberg
2019-2022
Klinikum Arnsberg
2022
University of Bamberg
2020-2021
MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as mediators of disease pathology via coordinated regulation molecular effector pathways. Unraveling miR disease-related activities will facilitate future therapeutic interventions. miR-155 recently has been identified with critical immune regulatory functions. Although detected in articular tissues, the functional role inflammatory arthritis not defined. We report here that is up-regulated synovial membrane fluid...
Epstein-Barr virus-induced gene 3 (EBI3) and the p35 subunit of IL-12 have been reported to form a heterodimeric hematopoietin in human mouse. We constructed protein covalently linking EBI3 p35, novel cytokine which we now call IL-35. The Fc fusion IL-35 induced proliferation murine CD4(+)CD25(+) CD4(+)CD25(-) T cells when stimulated with immobilized anti-CD3 anti-CD28 antibodies vitro. IL-35-expanded cell population expressed Foxp3 produced elevated levels IL-10, whereas IL-35-induced...
The proinflammatory cytokine IL-17A is considered a crucial player in rheumatoid arthritis (RA) pathogenesis. In experimental models of autoimmune arthritis, it has been suggested that the cellular source CD4(+) T cells (Th17 cells). However, little known about IL-17 human inflamed RA tissue. We explored sources synovium. Surprisingly, only small proportion IL-17-expressing were cells, and these CCR6 negative. Unexpectedly, majority expression colocalized within mast cells. Furthermore, we...
Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in tissue, but their role during obesity is unclear.To examine functional IL-33 tissues investigate effects on vivo.We demonstrate that treatment cultures vitro with induced production Th2 cytokines (IL-5, IL-13, IL-10) reduced expression adipogenic genes. Administration recombinant genetically obese diabetic...
Anticitrullinated protein antibodies (ACPA) are a major risk factor for bone loss in rheumatoid arthritis (RA). We have recently shown that ACPA directly induce by stimulating osteoclast differentiation. As precede the clinical onset of RA years, we hypothesised positive healthy individuals may already show skeletal changes.We performed comparative micro-CT analysis microstructure metacarpophalangeal joints and negative without signs arthritis.ACPA (n=15) were not different age (48.2±4.1 vs...
Background The cellular mechanisms of tendinopathy remain unclear particularly with respect to the role inflammation in early disease. authors previously identified increased levels inflammatory cytokines an human model and sought extend these studies analysis tissue. Purpose To characterize cell subtypes tendinopathy, explored phenotype quantification cells torn control tendon samples. Design Controlled laboratory study. Methods Torn supraspinatus matched intact subscapularis samples were...
<h3>Objective</h3> To prospectively analyse the risk for disease relapses in patients with rheumatoid arthritis (RA) sustained remission, either continuing, tapering or stopping disease-modifying antirheumatic drugs (DMARDs) a prospective randomised controlled trial. <h3>Methods</h3> Reduction of Therapy Rheumatoid Ongoing remission is multicentre, controlled, parallel-group phase 3 trial evaluating effects and all conventional and/or biological DMARDs RA stable remission. Patients (disease...
To better understand the factors that influence humoral immune response to vaccination against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs).Patients and controls from a large COVID-19 study, (1) no previous history of COVID-19, (2) negative baseline anti-SARS-CoV-2 IgG test (3) at least 10 days before serum collection were measured for IgG. Demographic, disease-specific vaccination-specific data recorded.Vaccination responses 84 IMID 182 analysed. While all...
Mobile health (mHealth) defines the support and practice of care using mobile devices promises to improve current treatment situation patients with chronic diseases. Little is known about mHealth usage digital preferences rheumatic diseases.The aim study was explore usage, preferences, barriers, eHealth literacy reported by German diseases.Between December 2018 January 2019, (recruited consecutively) rheumatoid arthritis, psoriatic axial spondyloarthritis were asked complete a paper-based...
The molecular mechanisms of syndesmophyte formation in ankylosing spondylitis (AS) are yet to be characterised. Molecules involved bone such as Wnt proteins and their antagonists probably drive AS.This study investigated sequential serum levels functional dickkopf-1 (Dkk1), a potent antagonist arthritis, by capture ELISA with its receptor LRP6 65 AS patients from the German Spondyloarthritis Inception Cohort. Dkk1 were then related structural progression (syndesmophyte formation) well...
Psoriasis is a common chronic autoimmune condition of the skin characterized by hyperplasia epidermal keratinocytes associated with pro-inflammatory cytokines. IL-33 new member IL-1 superfamily that signals through ST2 receptor and was originally defined as an inducer T helper 2 (Th2) Recently, broader immune activatory potential has been for particularly via mast cell activation neutrophil migration. Here, we show ST2(-/-) mice exhibit reduced cutaneous inflammatory responses compared WT in...
<h3>Objective</h3> Interleukin (IL)-36R signalling plays a proinflammatory role in different organs including the skin, but expression of IL-36R ligands and their molecular function intestinal inflammation are largely unknown. <h3>Design</h3> We studied characteristics ligand IBDs experimental colitis. The functional intestine was addressed colitis wound healing models vivo by using mice with defective (<i>IL-36R</i>−/−) or Myd88, neutralising anti-IL-36R antibodies, recombinant RNA-seq...
<h3>Abstract</h3> Previously, we classified colorectal cancers (CRCs) into five CRCA subtypes with different prognoses and potential treatment responses, using a 786-gene signature. We merged our those described by other groups four consensus molecular (CMS) that are similar to subtypes. Here demonstrate the analytical development application of custom NanoString platform-based biomarker assay stratify CRC To reduce costs, switched from standard protocol modified (NanoCRCA) high Pearson...
Rheumatoid arthritis therapies that are based on inhibition of a single cytokine, e.g., tumor necrosis factor α (TNFα) or interleukin-6 (IL-6), produce clinically meaningful responses in only about half the treated patients. This study was undertaken to investigate whether combined TNFα and IL-17 has additive synergistic effects suppression mesenchymal cell activation vitro inflammation tissue destruction vivo.Cultures human fibroblast-like synoviocytes (FLS) were stimulated with TNFα,...
Abstract Th2–eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of in counteracting the development arthritis. In two independent models arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation joints associated with robust inhibition arthritis protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, show that...
JAK inhibition enhances the function of bone-forming osteoblasts, increases bone mass, and induces repair arthritic erosions.
To search for subclinical inflammatory joint disease in patients with psoriasis without psoriatic arthritis (PsA), and to determine whether such changes are associated the later development of PsA.Eighty-five subjects (55 30 healthy controls) received high field MRI hand. scans were scored synovitis, osteitis, tenosynovitis periarticular inflammation according PsAMRIS method. Patients additionally complete clinical investigation, high-resolution peripheral quantitative CT detecting erosions...
Immune-mediated inflammatory diseases (IMIDs) of the joints, gut and skin are treated with inhibitors cytokines. These cytokines involved in pathogenesis coronavirus disease 2019 (COVID-19). Investigating anti-SARS-CoV-2 antibody responses IMIDs we observe a reduced incidence SARS-CoV-2 seroconversion IMID patients cytokine compared to receiving no such two healthy control populations, despite similar social exposure. Hence, seem at least partially protect from infection.
A specific subset of psoriasis patients is characterized by subclinical inflammatory changes. These frequently present with arthralgia and have a higher risk to develop psoriatic arthritis (PsA). We hypothesized that IL-17A inhibition in this can intercept the link between skin joint disease resolves pain Psoriasis, but no PsA, were included open prospective exploratory Interception very early PsA (IVEPSA) study. Patients had nail or scalp involvement high area severity index (PASI) (> 6) as...
Objective B cell depletion is an established therapeutic principle in a wide range of autoimmune diseases. However, cells are also critical for inducing protective immunity after infection and vaccination. We undertook this study to assess humoral cellular immune responses with or vaccination against SARS–CoV‐2 patients controls who cell–competent. Methods Antibody (tested using enzyme‐linked immunosorbent assay) T interferon‐γ immunospot the spike S1 nucleocapsid proteins were assessed...
Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection blood for the analysis inflammation markers autoantibodies could improve monitoring RA facilitate identification individuals at-risk RA.
Symptom checkers are increasingly used to assess new symptoms and navigate the health care system. The aim of this study was compare accuracy an artificial intelligence (AI)-based symptom checker (Ada) physicians regarding presence/absence inflammatory rheumatic disease (IRD). In survey study, German-speaking with prior rheumatology working experience were asked determine IRD suggest diagnoses for 20 different real-world patient vignettes, which included only basic symptom-related medical...