A5039485840- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal Disorders and Rehabilitation
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Social Media in Health Education
- Innovations in Medical Education
- Vasculitis and related conditions
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Mobile Health and mHealth Applications
- Adolescent and Pediatric Healthcare
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Endometrial and Cervical Cancer Treatments
- Neurogenetic and Muscular Disorders Research
- Genomic variations and chromosomal abnormalities
- Health and Medical Studies
- Empathy and Medical Education
- Health Literacy and Information Accessibility
Heinrich Heine University Düsseldorf
2016-2025
Düsseldorf University Hospital
2016-2024
First Hospital of China Medical University
2023
Xian Central Hospital
2023
Université Laval
2023
Toronto General Hospital
2023
Toronto General Hospital Research Institute
2023
Deutsche Gesellschaft für Urologie
2020-2022
Medizinische Hochschule Hannover
2014-2022
AstraZeneca (France)
2022
Objectives To update the EULAR recommendations for management of systemic lupus erythematosus (SLE) based on emerging new evidence. Methods An international Task Force formed questions systematic literature reviews (January 2018–December 2022), followed by formulation and finalisation statements after a series meetings. A predefined voting process was applied to each overarching principle recommendation. Levels evidence strengths recommendation were assigned, participants finally provided...
Background Chronic rheumatic diseases need long-term treatment and professional supervision. Mobile apps promise to improve the lives of patients physicians. In routine practice, however, rheumatology are largely unknown little is known about their quality safety. Objective The aim this study was provide an overview mobile currently available in German app stores, evaluate using Application Rating Scale (MARS), compile brief, ready-to-use descriptions for rheumatologists. Methods App Store...
Objective To analyse the impact of COVID-19 pandemic on rheumatic patients’ and rheumatologists’ usage, preferences perception digital health applications (DHAs). Methods A web-based national survey was developed by Working Group Young Rheumatology German Society for League against Rheumatism. The prospective distributed via social media (Twitter, Instagram Facebook), QR code email. Descriptive statistics were calculated, regression analyses performed to show correlations. Results We...
Symptom checkers are increasingly used to assess new symptoms and navigate the health care system. The aim of this study was compare accuracy an artificial intelligence (AI)-based symptom checker (Ada) physicians regarding presence/absence inflammatory rheumatic disease (IRD). In survey study, German-speaking with prior rheumatology working experience were asked determine IRD suggest diagnoses for 20 different real-world patient vignettes, which included only basic symptom-related medical...
The global COVID-19 pandemic has led to drastic changes in the management of patients with rheumatic diseases. Due imminent risk infection, monitoring intervals have prolonged. aim this study is present insights from patients, rheumatologists, and digital product developers on ongoing health transition rheumatology. A qualitative participatory semi-structured fishbowl approach was conducted gain detailed a total 476 participants. main findings show that remote care are generally welcomed by...
To determine whether disease remission or low activity state at the beginning of pregnancy in SLE patients is associated with better outcome.Pregnancies prospectively monitored by clinics four rheumatology centres were enrolled. Patient demographics and clinical information collected baseline (pregnancy visit before 8 weeks gestation) including according to Definition Remission (DORIS) criteria and/or Lupus Low Disease Activity State (LLDAS). Univariate multivariate analysis performed...
To evaluate the feasibility, accuracy, usability and acceptability of two upper arm self-sampling devices for measurement autoantibodies C reactive protein (CRP) levels in patients with immune-mediated rheumatic diseases (IMRDs).70 consecutive IMRD previously documented were assigned to supervised unsupervised self-collection capillary blood Tasso+ or TAP II device. Interchangeability 17 biomarkers standard venesection was assessed by: concordance, correlation, paired sample hypothesis...
We report on further cases of high functioning fragile X males showing decreased expression FMR1 protein, absence detectable methylation at the EagI site in gene promoter, and highly unusual patterns mutations defined as smear expansions extending from premutation to full mutation range. Very diffuse therefore not easily were also observed prenatal testing using DNA chorionic villi sampled a time development when still unmethylated this particular tissue. In search for possible determinants...
Background and Purpose Due to its sensitivity deoxyhemoglobin, susceptibility weighted imaging (SWI) enables the visualization of deep medullary veins (DMV) in patients with acute stroke, which are difficult depict under physiological circumstances. This study assesses asymmetric appearance prominent DMV as an independent predictor for stroke severity outcome. Materials Methods SWI 86 middle cerebral artery (MCA) were included. A scoring system from 0 (no visible DMV) 3 (very was applied...
Background The use of patient-reported outcomes (PROs) allows for patient-centered, measurable, and transparent care. Electronic PROs (ePROs) have many benefits hold great potential to improve current usage PROs, yet limited evidence exists regarding their acceptance, usage, barriers among rheumatologists. Objective This study aims evaluate the level German rheumatologists ePROs. importance different ePRO features was investigated. Additionally, most frequently used patients with rheumatoid...
Time-of-flight (TOF) angiography detects embolic occlusion of arteries in patients with acute ischemic stroke due to the absence blood flow occluded vessel. In contrast, susceptibility weighted imaging (SWI) directly enables intravascular clot visualization hypointense vessel signs (SVS) The aim this study was compare diagnostic accuracy both methods determine stroke.
Inhomogeneity of immune cell distribution in the synovial sublining layer was analyzed order to improve our mechanistic understanding inflammation and explore potential refinements for histological biomarkers rheumatoid arthritis (RA) osteoarthritis (OA). Synovial tissue 20 patients (11 RA, 9 OA) immunohistochemically stained macrophages (CD68), fibroblasts (CD55), T cells (CD3), plasma (CD38), endothelial (vWF) mast (MCT). The divided into predefined adjacent zones fractions area (SA) were...
<h3>Objective</h3> Precise detection of sentinel lymph nodes (SLNs) seems to be a crucial factor for optimized treatment cervical cancer. We assess the use single photon emission computed tomography combined with (SPECT/CT) as an alternative lymphoscintigraphy (LSG) preoperative identification SLN. <h3>Methods</h3> This study was performed in prospective, unicentric setting. Patients carcinoma were scheduled surgery and additional SLN labeling by peritumoral injection 10 MBq...
Abstract Objective A steadily increasing demand and decreasing number of rheumatologists push current rheumatology care to its limits. Long travel times poor accessibility present particular challenges for patients. Need-adapted, digitally supported, patient-centered flexible models could contribute maintaining high-quality patient care. This qualitative study was embedded in a randomized controlled trial (TELERA) investigating new model consisting the use medical app ePRO (electronic...
Innovative strategies are needed to adequately assess and monitor disease activity of patients with rheumatoid arthritis (RA) in times scarce appointments. The aim the TELERA study is evaluate feasibility performance asynchronous telemedicine visits based on patient-generated data patient's drug history. RA use a medical app, ABATON, that captures results self-performed quick CRP-test, joint-count, electronic patient-reported outcomes between visits. This prospective, multi-center,...
Background Inflammatory arthritides (IA) such as rheumatoid arthritis or psoriatic are disorders that can be difficult to comprehend for health professionals and students in terms of the heterogeneity clinical symptoms pathologies. New didactic approaches using innovative technologies virtual reality (VR) apps could helpful demonstrate disease manifestations well joint pathologies a more comprehensive manner. However, potential VR education concept IA has not yet been evaluated. Objective We...
Introduction As chronic systemic autoimmune disease, which can affect every organ, SLE is creating significant burden and increased mortality. Despite better outcomes over the past decades by optimising standard of care, new interventions are needed for further improvements. Changing strategy to ‘treat-to-target’ (T2T) may be a promising concept proven successful in other diseases. Methods analysis In this cluster-randomised trial, centres will assigned 1:1:1 care (SoC), remission (no...
The primary aim of the CHANGE survey is to determine current state gender equity within rheumatology, and secondarily, review physician perspective on bullying, harassment equipoise opportunities rheumatology. e-survey a cross-sectional self-reported questionnaire adapted from EULAR's in academic rheumatology task force. was launched January 2023; it available six languages distributed widely via organizations social media. Eligible participants include rheumatologist physicians health-care...
Objective It is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact LDASA on pregnancy outcomes in without history renal involvement and antiphospholipid antibodies (aPL). Methods retrospective analysis prospectively monitored pregnancies seven rheumatology centres. Previous/current aPL positivity were exclusion criteria. Adverse outcome (APO) composite included...
We present high-energy spectroscopy results on the occupied and unoccupied electronic structures of strongly anisotropic compounds ${\mathrm{MoO}}_{3}$ ${\mathrm{K}}_{0.3}{\mathrm{MoO}}_{3}$ near Fermi level. X-ray photoemission reveals a close similarity valence-band spectra in both materials. The metal shows an additional Mo $4d$-derived conduction band whose population is achieved by electron transfer from K to Mo. This concluded studies intentional surface doping insulating which leads...