A5035984700- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes and associated disorders
- Inflammatory Bowel Disease
- Multiple Sclerosis Research Studies
- Celiac Disease Research and Management
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Skin Diseases and Diabetes
- Fatty Acid Research and Health
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Peripheral Neuropathies and Disorders
- Lipid metabolism and disorders
- Reproductive System and Pregnancy
- Vasculitis and related conditions
University of Calgary
2016-2025
Alberta Bone and Joint Health Institute
2021-2025
Brigham and Women's Hospital
2020-2024
Harvard University
2020-2024
Chinese University of Hong Kong
2024
University of Hong Kong
1996-2024
Novo Nordisk (United Kingdom)
2024
Universidade Estadual de Campinas (UNICAMP)
2022
Hamilton Health Sciences
2016
Smiths Detection (Canada)
2016
The spectrum of antinuclear antibodies (ANAs) is changing to include both nuclear staining as well cytoplasmic and mitotic cell patterns (CMPs) accordingly a change occurring in terminology anticellular antibodies. This study examined the prevalence indirect immunofluorescence (IIF) antibody using Systemic Lupus International Collaborating Clinics inception cohort.
A novel longitudinal clustering technique was applied to comprehensive autoantibody data from a large, well-characterised, multinational inception systemic lupus erythematosus (SLE) cohort determine profiles predictive of clinical outcomes.
To determine whether disease remission or low activity state at the beginning of pregnancy in SLE patients is associated with better outcome.Pregnancies prospectively monitored by clinics four rheumatology centres were enrolled. Patient demographics and clinical information collected baseline (pregnancy visit before 8 weeks gestation) including according to Definition Remission (DORIS) criteria and/or Lupus Low Disease Activity State (LLDAS). Univariate multivariate analysis performed...
Autoantibodies to dense fine speckles 70 (DFS70) are purported rule out the diagnosis of SLE when they occur in absence other SLE-related autoantibodies. This study is first report prevalence anti-DFS70 an early, multinational inception cohort and examine demographic, clinical, autoantibody associations. Patients were enrolled Systemic Lupus International Collaborating Clinics (SLICC) within 15 months diagnosis. The association between multiple parameters 1137 patients was assessed using...
OBJECTIVE: Sporadic Inclusion Body Myositis (sIBM) is an inflammatory myopathy (IIM) without a specific diagnostic biomarker until autoantibodies to cytosolic 5'-nucleotidase 1A (NT5c1A/Mup44) were reported. The objectives of our study determine the sensitivity and specificity anti-NT5c1A for sIBM, demonstrate demographic, clinical serological predictors positivity if anti-nuclear antibody (ANA) indirect immunofluorescence (IIF) staining on HEp-2 cells reliable screening method anti-NT5c1A....
While previous studies have demonstrated an association between individual factors related to lifestyle and the risk of systemic lupus erythematosus (SLE), it is unclear how combination these might affect incident SLE. This study was undertaken prospectively evaluate whether a healthy associated with lower SLE its subtypes (anti-double-stranded DNA [anti-dsDNA]-positive anti-dsDNA-negative SLE).
Objective Cognitive impairment (CI) is one of the most common manifestations Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Despite its frequency, we have a limited understanding underlying immune mechanisms, resulting in lack pathways to target. This study aims bridge this gap by investigating differences serum analyte levels SLE patients based on their cognitive performance, independently from attribution SLE, and exploring potential for various analytes differentiate between with...
To investigate whether a healthy lifestyle, defined by lifestyle index score (HLIS), was associated with rheumatoid arthritis (RA) risk, overall and seropositive/seronegative subtypes.
A perception derived from cross-sectional studies of small systemic lupus erythematosus (SLE) cohorts is that there a marked discrepancy between antinuclear antibody (ANA) assays, which impacts on clinicians' approach to diagnosis and follow-up. We compared three ANA assays in longitudinal analysis large international incident SLE cohort retested regularly followed for 5 years.
Cardiovascular disease (CVD) risk is increased in SLE and underestimated by general population prediction algorithms. We aimed to develop a novel SLE-specific tool, SLECRISK, provide more accurate estimate of CVD SLE.
Precision health (PH) applied to autoimmune disease will need paradigm shifts in the use and application of autoantibodies other biomarkers. For example, combined with multi-analyte "omic" profiles form basis prediction allowing for earlier intervention linked prevention strategies, as well earlier, effective personalized interventions established disease. As medical moves a model "intent PREVENT," diagnostics include an early symptom/risk-based, opposed disease-based approach. Newer...
Objective Screening for cognitive impairment in systemic lupus erythematosus (SLE) conventionally relies on the American College of Rheumatology (ACR) neuropsychologic battery (NB), which is not universally available. To develop a more accessible screening approach, we assessed validity Automated Neuropsychological Assessment Metrics (ANAM). Using ACR NB as gold standard classification, objectives were 1) to measure overall discriminative ANAM versus no impairment, 2) identify subtests and...
INTRODUCTION: Food insecurity is associated with negative nutritional outcomes and experienced differently by women vs men. We evaluated the effects of gender on food dietary intake in United States. METHODS: Data from National Health Nutrition Examination Survey (2007–2016) were analyzed. Survey-weighted linear logistic regression models used to evaluate predictors security effect consumption body anthropometrics. Gender was modeled as a covariable an modifier. RESULTS: A total 30,251...