A5003836713- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Medication Adherence and Compliance
- Liver Disease Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Biosimilars and Bioanalytical Methods
- Opioid Use Disorder Treatment
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
- Inflammatory Bowel Disease
- Pharmaceutical Practices and Patient Outcomes
- Posttraumatic Stress Disorder Research
- Diabetes and associated disorders
- Herpesvirus Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Ocular Diseases and Behçet’s Syndrome
- Chronic Disease Management Strategies
Brigham and Women's Hospital
2015-2024
Harvard University
2004-2024
Quinnipiac University
2024
Massachusetts General Hospital
2024
The incidence of systemic lupus erythematosus (SLE) is disproportionately high in nonwhite patients compared with white patients. However, variation mortality according to race/ethnicity has not been well studied. aim this study was examine all-cause among SLE enrolled Medicaid.We used Medicaid Analytic eXtract data, billing claims from 47 US states and Washington, DC, identify individuals ages 18-65 years who were for ≥3 months 2000-2006. Individuals classified as having if they had visits...
We examined whether nonadherence to hydroxychloroquine (HCQ) or immunosuppressive medications (ISMs) was associated with higher subsequent acute care utilization among Medicaid beneficiaries systemic lupus erythematosus (SLE).We utilized US data from 2000-2006 identify adults ages 18-64 years SLE who were new users of HCQ ISMs. defined the index date as receipt ISMs without use in prior 6 months. measured adherence using medication possession ratio (MPR), proportion days covered by total...
<h3>Introduction</h3> Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA). The association longitudinal RA activity with long-term function has remained uncertain. <h3>Method</h3> We analysed multicentre prospective registry in the USA from 2001 to 2022. exposure was updated time-averaged Clinical Disease Activity Index (TA-CDAI) categories study enrolment. primary outcome estimated glomerular filtration rate (eGFR) change. Secondary outcomes included...
Objective Systemic lupus erythematosus (SLE) is more prevalent and results in severe outcomes among blacks, Asians, Hispanics than whites. Cardiovascular disease (CVD) the leading cause of death SLE patients. We undertook this study to examine racial/ethnic variations risk CVD events Methods Within Medicaid Analytic eXtract from 2000 2010, we identified patients ages 18–65 years with (≥3 International Classification Diseases, Ninth Revision 710.0 codes, ≥30 days apart) ≥12 months continuous...
Objective While infection burden is high among patients with systemic lupus erythematosus (SLE), there uncertainty about whether rates differ by immunosuppressive drug regimens. We undertook this study to compare SLE newly initiating therapy mycophenolate mofetil (MMF), azathioprine (AZA), or cyclophosphamide (CYC). Methods Within the Medicaid Analytic eXtract database (2000–2010; 29 most populated US states), we identified adults starting MMF, AZA, CYC treatment. estimated propensity scores...
Cardiovascular disease (CVD) risk is increased in SLE and underestimated by general population prediction algorithms. We aimed to develop a novel SLE-specific tool, SLECRISK, provide more accurate estimate of CVD SLE.
The opioid epidemic is a major public health concern. However, little known about use among rheumatoid arthritis (RA) patients. We undertook this study to examine trends in chronic RA patients 2002-2015 and identify clinical predictors.RA were identified from the Corrona registry. Opioid was ascertained surveys obtained at visits as often every 3 months. Chronic defined any reported during ≥2 consecutive visits. Annual prevalence of calculated using data 33,739 with information on Among...
Objective The chronicity and severity of childhood-onset systemic lupus erythematosus (cSLE) necessitate effective transition from pediatric to adult providers. We studied outcomes in a cSLE cohort. Methods identified patients at an clinic diagnosed with SLE ≤ 18 years who had been followed by rheumatologist. Data extracted the first three care (“post-transition period”) included: sociodemographics, depression, anxiety, manifestations, Disease Activity Index (SLEDAI) Systemic Lupus...
To identify racial and ethnic differences in mortality cardiovascular (CV) risk among patients with end-stage renal disease (ESRD) due to lupus nephritis (LN).Within the US ESRD registry (1995-2008), we identified individuals ages >17 years incident systemic erythematosus. We ascertained demographics, clinical factors, deaths from patient files CV events (myocardial infarction, heart failure, hemorrhagic ischemic strokes) inpatient Medicare claims. calculated incidence rates (95% confidence...
Past studies have focused on aggregate lupus disease activity during pregnancy and produced conflicting results. Our study evaluated based involvement of five specific organ systems the six months prior to conception pregnancy. We assessed 147 pregnancies among 113 women followed at Brigham Women’s Lupus Center, 1990–2013. Organ-specific included hematologic disorder, nephritis, skin disease, arthritis, serositis. hypothesized that presence organ-specific would increase risk for same type...
To investigate the nationwide prevalence and incidence of serious infections among children with systemic lupus erythematosus (SLE) enrolled in Medicaid, US health insurance program for low-income patients.From Medicaid claims (2000-2006) we identified ages 5 to <18 years SLE (≥3 International Classification Diseases, Ninth Revision [ICD-9] codes 710.0, each >30 days apart) nephritis (LN; ≥2 ICD-9 kidney disease on/after codes). From hospital discharge diagnoses, infection subtypes...
Objective Cardiovascular disease (CVD) risk is elevated in patients with systemic lupus erythematosus (SLE) and diabetes mellitus (DM), but whether of CVD SLE as high those DM unknown. The present study was undertaken to compare risks between general population US Medicaid recipients. Methods In a cohort study, we identified age‐ sex‐matched adults (1:2:4) or from the using Analytic eXtract, 2007–2010. We collected data on baseline sociodemographic factors, comorbidities, medications. used...
Poor bone health is common in systemic lupus erythematosus (SLE) patients. This study was undertaken to evaluate fracture risks among low-income SLE and nephritis patients compared those without SLE.We performed a cohort for whom there were Medicaid claims 2007-2010, age- sex-matched non-SLE comparators. defined by the presence of ≥3 International Classification Diseases, Ninth Revision codes SLE. Patients with additionally had ≥2 renal disease. The primary outcome measure pelvis, wrist,...
Objective Tocilizumab (TCZ) has shown similar efficacy when used as monotherapy in combination with other treatments for rheumatoid arthritis (RA) randomized controlled trials (RCTs). We derived a remission prediction score TCZ (TCZm) using RCT data and performed an external validation of the real-world (RWD). Methods identified patients Corrona RA registry who TCZm (n = 452), matched design from 4 RCTs previous work 853). Patients were followed to determine status at 24 weeks. compared...
PV080 / #137 Poster Topic: AS11 - Epidemiology and Public Health Background/Purpose Mental health disorders, including depression, anxiety, post-traumatic stress disorder, are prevalent among people living with SLE. We hypothesized that these mental conditions may increase recurrent acute care use (emergency department [ED] visits, hospitalizations) patients Methods used data from the nationwide All of Us Research Program (version 7), an NIH cohort >287,000 U.S. adults who enrolled...
While systemic lupus erythematosus and nephritis (LN) disproportionately affect females, previous studies suggest that males may experience poorer outcomes. We undertook this study to investigate sex differences in health care utilization, end-stage renal disease (ESRD), mortality among patients with LN receiving Medicaid, public insurance for low-income individuals.
SLE is associated with high risks of cardiovascular disease (CVD) and mortality, has a wide spectrum presentations. We investigated whether severity at diagnosis was CVD or mortality risk.Within Medicaid (2000-10), we identified patients 18-65 years age incident SLE. Initial classified-mild, moderate, severe-during the baseline year prior to start follow-up (incident index date) using published algorithm based on SLE-related medications diagnoses. Patients were followed from date first event...
To identify interactions between genetic factors and current or recent smoking in relation to risk of developing systemic lupus erythematosus (SLE).For the study, 673 patients with SLE (diagnosed according American College Rheumatology 1997 updated classification criteria) were matched by age, sex, race (first 3 principal components) 3,272 control subjects without a history connective tissue disease. Smoking status was classified as smoking/having recently quit within 4 years before...
It is unknown how the relationship between disease activity in rheumatoid arthritis (RA) and cardiovascular (CV) events may change over time. We examined potentially time-varying association of RA to CV events.We used CorEvitas prevalent registry. The Clinical Disease Activity Index (CDAI) score category, averaged within each 6-month window since enrollment, was exposure, outcome major adverse (MACEs). marginal structural models estimate hazard ratio (HR), comparing CDAI category with...
We studied posttraumatic stress disorder (PTSD), a severe trauma-related mental disorder, and systemic lupus erythematosus (SLE) risk in large, diverse population enrolled Medicaid, US government-sponsored health insurance program for low-income individuals.