A5002583726- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Otitis Media and Relapsing Polychondritis
- Peripheral Neuropathies and Disorders
- Inflammasome and immune disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Salivary Gland Disorders and Functions
- Respiratory viral infections research
- Spondyloarthritis Studies and Treatments
- Neurogenetic and Muscular Disorders Research
- Inflammation biomarkers and pathways
- Animal Virus Infections Studies
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Oral microbiology and periodontitis research
- Acute Lymphoblastic Leukemia research
- Intramuscular injections and effects
- Viral Infectious Diseases and Gene Expression in Insects
- Multiple Sclerosis Research Studies
- Hematological disorders and diagnostics
- Musculoskeletal Disorders and Rehabilitation
Charité - Universitätsmedizin Berlin
2009-2025
Humboldt-Universität zu Berlin
2020-2023
Freie Universität Berlin
2021-2023
Center for Rheumatology
2014
Background: A limited number of studies suggest a higher prevalence periodontal disease among individuals with rheumatoid arthritis (RA); however, results have been inconsistent. Further, it is unclear to what extent poor oral hygiene patients RA may account for this association. Methods: The association between and periodontitis was examined in 57 subjects 52 healthy controls, matched by age gender. Oral examination included plaque index (PI), gingival (GI), probing depth (PD), clinical...
Adult-onset Still's disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable clinical features of AOSD and SJIA suggest both phenotypes represent the same continuum with different ages onset. To further characterize similarity between at molecular level, 2 previously identified response gene sets in were used to investigate how genes that respond interleukin (IL)-1β inhibition canakinumab patients behave active prior IL-1β...
Inhibition of interleukin (IL)-1 represents a promising treatment option in adult-onset Still's disease (AOSD).
To study the effect of methotrexate (MTX) and its discontinuation on humoral immune response after COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD).In this retrospective study, neutralising SARS-CoV-2 antibodies were measured second 64 AIRD MTX therapy, 31 whom temporarily paused medication without a fixed regimen. The control group consisted 21 immunosuppressive medication.Patients showed significantly lower mean antibody compared therapy (71.8% vs 92.4%, p<0.001)....
Journal Article Accepted manuscript Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis rheumatoid arthritis Get access Fredrik N Albach, Albach Department of Rheumatology Clinical Immunology, Charité - Universitätsmedizin Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Ioanna Minopoulou, Minopoulou Artur Wilhelm, Wilhelm GermanyDeutsches Rheuma-Forschungszentrum Robert Biesen, Biesen...
Objective The development of sufficient COVID-19 vaccines has been a big breakthrough in fighting the global SARS-CoV-2 pandemic. However, vaccination effectiveness can be reduced patients with autoimmune rheumatic diseases (AIRD). aim this study was to identify factors that lead diminished humoral response AIRD. Methods Vaccination measured surrogate virus neutralisation test and by testing for antibodies directed against receptor-binding-domain (RBD) 308 fully vaccinated In addition, 296...
Objective: Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft hard connective tissue destruction. AS has been related to other diseases, however, there is a paucity data on whether associated with PD. Methods: The association between PD was examined 48 patients healthy controls, matched for age gender. diagnosed according modified New York criteria. Periodontal examination included probing pocket...
Objective The level of neutralising capacity against Omicron BA.1 and BA.2 after third COVID-19 vaccination in patients on paused or continuous methotrexate (MTX) therapy is unclear. Methods In this observational cohort study, serum activity SARS-CoV-2 wild-type (Wu01) variant concern were assessed by pseudovirus neutralisation assay before, 4 12 weeks mRNA booster immunisation 50 rheumatic MTX, 26 whom the medication. 44 non-immunosuppressed persons (NIP) served as control group. Results...
Epigenetic modifications are dynamic and influence cellular disease activity. The aim of this study was to investigate global DNA methylation in peripheral blood mononuclear cells (PBMCs) RA patients clarify whether pattern testing might be useful monitoring activity as well the response therapeutics.Flow cytometric measurement 5-methyl-cytosine (5'-mC) established using cell line U937. In subsequent prospective study, 62 samples were investigated, including 17 healthy donors 45 at baseline...
Physical exercises and physiotherapy are of great importance for maintenance joint function in patients with rheumatoid arthritis (RA). However, many RA complain about problems to receive prescriptions or have a lack access physiotherapy. Recent reports shown positive effects the Wii game console on physical psychosocial conditions other underlying diseases. The primary objectives this prospective controlled pilot study were investigate feasibility patients' assessment using an animated...
Adult-onset Still's disease (AOSD) is a systemic auto-inflammatory characterized by the presence of immunologically mediated inflammation and deficient resolution inflammation. Canakinumab an approved IL-1β inhibitor in treatment AOSD with balanced efficacy safety profile. Since inflammatory cytokines play major role pathogenesis AOSD, we investigated effects canakinumab on cytokine profile patients from randomized controlled trial. Multiplex analysis ELISA were used to test concentrations...
<h3>Background</h3> Primary Sjögren9s syndrome (pSS) is a systemic autoimmune disease, with basically symptomatic treatment and use of conventional DMARDs on off-label use. Cyclosporine A (CyA), an approved DMARD for different rheumatic disorders, mainly used as local keratoconjunctivitis sicca in pSS, whereas reports effects are limited to small cohorts so far. Low-dose CyA has shown promising good tolerability other disorders [1, 2, 3]. <h3>Objectives</h3> To investigate the reduced dosage...
Objective Adult‐onset Still disease (AOSD) is a systemic autoinflammatory disorder (AID) of unknown etiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis large cohort with AOSD to investigate the underlying pathology identify novel targets for potential treatment. Methods We investigated cases (n = 60) rare germline somatic variants using whole exome sequencing virtual gene panels. Transcriptome profiles were by bulk RNA blood....
ABSTRACT Objective To study the effect of methotrexate (MTX) and its discontinuation on humoral immune response after COVID-19 vaccination in patients with autoimmune rheumatic diseases (AIRD). Methods In this retrospective study, neutralising SARS-CoV-2 antibodies were measured second 64 therapy, 31 whom temporarily paused medication without a fixed regimen. The control group consisted 21 AIRD immunosuppressive medication. Results MTX showed significantly lower mean antibody compared to...
<h3>Background</h3> Inhibition of interleukin-1 (IL-1) represents a promising treatment option in adult-onset Still’s disease (AOSD). Canakinumab (CAN) is approved for systemic juvenile idiopathic arthritis (sJIA) since 2013 and recently AOSD Europe. In sJIA, CAN has proven marked impact on articular activity, but RCT data limited. <h3>Objectives</h3> Investigation efficacy safety patients with joint involvement by means multi-centre, double-blinded, randomized, placebo controlled trial....
Background: Inhibition of interleukin-1 (IL-1) represents a promising treatment option in adult-onset Still's disease (AOSD). Canakinumab is approved for systemic juvenile idiopathic arthritis and has marked impact on as well articular activity the disease.Objective: To investigate efficacy safety canakinumab patients with AOSD active joint involvement by means multi-centre, double-blinded, randomized, placebo controlled trial. Methods: Patients (tender swollen count ≥4 each) were stratified...
ABSTRACT Objective To determine the immediate need for a fourth COVID-19 vaccination based on neutralizing capacity in patients methotrexate (MTX) therapy after mRNA booster immunization. Methods In this observational cohort study, serum activity against SARS-CoV-2 wildtype (Wu01) and variant of concern (VOC) Omicron BA.1 BA.2 were assessed by pseudovirus neutralization assay before, 4 12 weeks immunization 50 rheumatic MTX, 26 whom paused medication. 44 non-immunosuppressed persons (NIP)...
Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder resembling similar pediatric syndrome known as systemic juvenile idiopathic arthritis (SJIA).[1] The superimposable and clinical features in SJIA AOSD suggest that both phenotypes represent continuum with (SJIA) more adult-onset (AOSD).[2] Analyses of gene expression profiles may be useful not only for classification, diagnosis, prognosis, but also to identify specific treatment effects counteract the underlying...