A5090288111- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Bone health and osteoporosis research
- Lymphoma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Advanced X-ray and CT Imaging
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Cancer-related Molecular Pathways
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Orthopedic Surgery and Rehabilitation
- Biomarkers in Disease Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Otitis Media and Relapsing Polychondritis
- Health and Medical Studies
- Vitamin D Research Studies
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
Charité - Universitätsmedizin Berlin
2015-2024
Universidad Libre de Colombia
2024
Humboldt-Universität zu Berlin
2001-2023
Freie Universität Berlin
2016-2023
State and University Library
2023
Center for Rheumatology
2018
Universität Innsbruck
2011
University of Graz
2011
Ludwig-Maximilians-Universität München
2004
The University of Queensland
2004
Malfunctions of processes involved in cellular lipid storage and mobilization induce the pathogenesis prevalent human diseases such as obesity, type 2 diabetes atherosclerosis. Lipid droplets are main depots for neutral lipids eukaryotic cells, fulfil an essential function to balance metabolism energy homeostasis. Despite significant progress identifying key metabolic enzymes their regulation various model organisms, some fundamental questions biogenesis, subcellular distribution inheritance...
Objectives Inflammatory rheumatic and musculoskeletal diseases (iRMDs) are associated with increased systemic bone loss that is mediated by chronic inflammation, treatment glucocorticoids (GCs) other factors. Our objective was to analyse the impact of variables influence osteoporosis (OP) in patients iRMD treated GC. Methods Rh-GIOP (acronyme) a prospective observational cohort study investigating health consecutive current or prior GC treatment. We present an analysis patients’ baseline...
Objective Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations RA bone marrow (BM), blood Methods CD14 + cells from BM peripheral (PB) patients with osteoarthritis (OA) were profiled GeneChip microarrays. Detailed functional analysis was performed reference transcriptomes precursors, monocyte subsets, mobilisation. Cytometric profiling determined subsets ++ CD16 − , BM, PB synovial fluid (SF) ELISAs quantified...
Deregulation of cell death pathways contributes to tumor development and the clinical course cancer disease. In patients with liver metastases colorectal cancer, we have previously shown that an intact p53/BAX apoptotic pathway is a positive prognostic factor. Therefore, purpose our study was determine value BAX protein expression mutational status its upstream regulator p53 in primary adenocarcinoma. To this end, analyzed retrospectively samples 116 who underwent surgery for adenocarcinoma...
Abstract Deregulation of cell‐cycle G 1 ‐restriction point control by disruption Rb‐pathway components is a frequent event in cancer. In concert with the inactivation cell death pathways, such events not only contribute to tumor development but also determine intrinsic and acquired resistance cancer therapy and, ultimately, disease prognosis. We previously observed that cyclin‐dependent kinase inhibitor p16 INK4a proapoptotic Bcl‐2 homolog Bax are positive prognostic factors identify...
Dual-energy computed tomography detects tophi in patients with chronic gout. However, other information that can be obtained from the same scan is not focus of current research, e.g., detection bone marrow edema (BME) using virtual imaging (VBMI). The aim this study was to evaluate if BME acute arthritis detected VBMI magnetic resonance (MRI) as standard reference.This retrospective included 11 who underwent both MRI and dual-energy (mean interval 40 days). (standard reference) judged...
Abstract Advances in microbiome research suggest involvement chronic inflammatory diseases such as rheumatoid arthritis (RA). Searching for initial trigger(s) RA, we compared transcriptome profiles of highly inflamed RA synovial tissue (RA-ST) and osteoarthritis (OA)-ST with 182 selected reference transcriptomes defined cell types their activation by exogenous (microbial) endogenous stimuli. Screening dominant changes RA-ST demonstrated monocytes/macrophages gene-patterns induced bacterial...
The purpose of our study was to determine the expression pro-apoptotic BAX protein in relation mutational status and p53 (as transcriptional activator gene) benign malignant thyroid tissue. In 47 patients with tumours (14 follicular 3 papillary carcinomas, 14 adenomas 16 goitres), DNA screened for mutations (exon 1–6) 5–8) by single-strand conformation polymorphism polymerase chain reaction (SSCP-PCR). Furthermore, BAX, p21 (which is also increased transcriptionally p53) investigated...
Purpose To prove the feasibility and measure diagnostic accuracy of contrast-enhanced ultra-low-dose CT (ULD-CT) for depiction inflammatory soft-tissue changes (synovitis, tenosynovitis peritendonitis) in patients with arthritis hand. Materials methods In this institutional review board–approved study, 36 consecutive over age 50 suspected rheumatoid underwent ULD-CT (estimated radiation exposure <0.01 mSv) MRI hand weight-adapted intravenous contrast administration. subtraction MR images...
Abstract Background Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands rheumatic joint diseases with currently a lack long-term follow-up studies. Objective To investigate FOI for treatment monitoring homogenous cohort patients early (disease duration < 2 years) and active (DAS28 > 3.2) RA over period 12 months. Methods Thirty-five (24 (68.6%) females, mean age 53.3 years (SD 13.6)) were investigated clinically by DAS28, tender count (TJC) swollen...
Abstract Objectives To evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group order to gain insight into changes the extracellular matrix response crystal deposition. Materials methods This retrospective study included 28 (18 CPPD, 10 controls) who underwent DECT wrist. Collagen maps were reconstructed from datasets used measure...
Background: Glucocorticoids (GCs) can cause osteoporosis (OP). Prior observational research on bone density and the effects of GCs in polymyalgia rheumatica (PMR) vasculitides is scarce inconclusive. Methods: Rh-GIOP a prospective cohort study health patients with inflammatory rheumatic diseases. In this cross-sectional baseline analysis, we focused PMR different forms vasculitides. Multivariable linear regression was used to model effect current cumulative GC intake minimum T-score at any...
Abstract Background Fluorescence optical imaging (FOI) enables visualisation of inflammation in both hands rheumatoid arthritis (RA). Objective To investigate the usefulness FOI treatment monitoring under anti-TNFα therapy with certolizumab pegol (CZP) patients RA comparison to clinical and laboratory outcome parameters. Methods CZP-naïve were eligible for this open-label study an observational period 52 weeks. Disease activity was monitored by score DAS28, tender/swollen joint count...
Abstract Background It is unclear whether sex or age modify the association of glucocorticoid (GC) use with reduced bone mineral density (BMD) in patients rheumatoid arthritis (RA). Methods We studied cross-sectional data RA current previous GC treatment a single center cohort study ( Rh-GIOP cohort). Our primary outcome was minimum T-score (measured by DXA) either lumbar spine, total femur, femoral neck. Current dose main exposure; cumulative and duration were also assessed. Following...