A5080176966- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Peroxisome Proliferator-Activated Receptors
- HIV/AIDS drug development and treatment
- Protein Structure and Dynamics
- Advanced NMR Techniques and Applications
- Adolescent and Pediatric Healthcare
- Skin and Cellular Biology Research
- Horticultural and Viticultural Research
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Antibiotic Resistance in Bacteria
- Nuts composition and effects
- Galectins and Cancer Biology
- Neuroendocrine regulation and behavior
- Muscle Physiology and Disorders
- Cholesterol and Lipid Metabolism
- Food Safety and Hygiene
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
Tufts Medical Center
2019-2025
Novartis (United States)
1999-2017
Tufts University
2017
Novartis (Switzerland)
1997-2014
Boston Biomedical Research Institute
2014
Novartis Institutes for BioMedical Research
2014
Pathways Behavioral Services
2007-2008
Harvard University Press
1993
Harvard University
1991-1992
Michigan State University
1992
Objective Macrophage activation syndrome (MAS), a life‐threatening complication of systemic juvenile idiopathic arthritis (JIA), resembles familial hemophagocytic lymphohistiocytosis (HLH), constellation autosomal‐recessive immune disorders resulting from deficiency in cytolytic pathway proteins. We undertook this study to test our hypothesis that MAS predisposition JIA could be attributed rare gene sequence variants affecting the cytotolytic pathway. Methods Whole‐exome sequencing was used...
Adult-onset Still's disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable clinical features of AOSD and SJIA suggest both phenotypes represent the same continuum with different ages onset. To further characterize similarity between at molecular level, 2 previously identified response gene sets in were used to investigate how genes that respond interleukin (IL)-1β inhibition canakinumab patients behave active prior IL-1β...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurement of 13C relaxation times in proteins by two-dimensional heteronuclear 1H-13C correlation spectroscopyN. R. Nirmala and Gerhard. WagnerCite this: J. Am. Chem. Soc. 1988, 110, 22, 7557–7558Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ja00230a057https://doi.org/10.1021/ja00230a057research-articleACS PublicationsRequest reuse...
Using a bioinformatics approach, we have isolated novel G-protein-coupled receptor (GPCR), R527, and demonstrated that this shows no significant homology to previously deorphanized GPCRs. Quantitative reverse transcription-polymerase chain reaction analysis of the expression GPCR R527 indicated very high level mRNA in eosinophils, with also detected neutrophils lung macrophages. Stable cell lines were generated expressing together G-protein alpha-subunit G alpha(16). These cells used screen...
Chronic obstructive pulmonary disease (COPD) is a smoking-related that lacks effective therapies due partly to the poor understanding of pathogenesis. The aim this study was identify molecular pathways could be responsible for damaging consequences smoking. To do this, we employed Gene Set Enrichment Analysis analyze differences in global gene expression, which then related pathological changes induced by cigarette smoke (CS). Sprague-Dawley rats were exposed whole body CS 1 day and various...
Canakinumab is a human anti-interleukin-1β (IL-1β) monoclonal antibody neutralizing IL-1β-mediated pathways. We sought to characterize the molecular response canakinumab and evaluate potential markers of using samples from two pivotal trials in systemic juvenile idiopathic arthritis (SJIA).Gene expression was measured patients with febrile SJIA matched healthy controls by Affymetrix DNA microarrays. Transcriptional assessed gene changes baseline day 3 adapted JIA American College...
Abstract Low socioeconomic status (SES) is thought to exacerbate risks for bacterial infections, but global evidence this relationship has not been synthesized. We systematically reviewed the literature studies describing participants’ SES and their risk of colonization or community-acquired infection with priority pathogens. Fifty from 14 countries reported outcomes by education, healthcare access, income, residential crowding, deprivation score, urbanicity, sanitation access. educational...
Objective To explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS). Methods Blood samples were collected from 20 patients active TRAPS who received 150 mg every 4 weeks months an open-label proof-of-concept phase II study, and aged-matched healthy volunteers. Gene levels evaluated whole blood by microarray analysis arrays passing...
Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression genes required for uptake and synthesis cholesterol, fatty acids, triglycerides. SREBPs are thus essential insulin-induced lipogenesis cellular membrane homeostasis biogenesis. Although multiple players have been identified activation SREBPs, gaps remain our understanding how coordinated with other physiological pathways.To...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequence-specific proton and nitrogen-15 resonance assignments for human dihydrofolate reductase in solutionBrian J. Stockman, N. R. Nirmala, Gerhard Wagner, Tavner Delcamp, Michael T. DeYarman, James H. FreisheimCite this: Biochemistry 1992, 31, 1, 218–229Publication Date (Print):January 14, 1992Publication History Published online1 May 2002Published inissue 14 January...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransfer nuclear Overhauser effect study of the conformation oxytocin bound to bovine neurophysin IG. Lippens, D. Van Belle, S. J. Wodak, K. Hallenga, N. R. Nirmala, P. Hill, C. Russell, Smith, and V. HrubyCite this: Biochemistry 1993, 32, 36, 9423–9434Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://doi.org/10.1021/bi00087a022Request reuse permissionsArticle...