A5069203531- Cancer and Skin Lesions
- Ear and Head Tumors
- Nail Diseases and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Cervical Cancer and HPV Research
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Histiocytic Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Tumors and Oncological Cases
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- Genetic and rare skin diseases.
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Neuroblastoma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Parvovirus B19 Infection Studies
- Advanced Antenna and Metasurface Technologies
- Skin and Cellular Biology Research
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
University of the Witwatersrand
2009-2023
South African Medical Research Council
2023
University of Johannesburg
2023
Education Labour Relations Council
2023
Right to Care
2023
University of the Free State
2023
University of Pretoria
2023
National Institute for Communicable Diseases
2023
Milpark Hospital
2022
National Health Laboratory Service
2002-2020
Rosai-Dorfman disease (RDD) is a rare but distinctive clinicopathologic entity of unknown etiology affecting lymph nodes as well extranodal sites. Although cutaneous involvement in RDD common, purely and not documented. We report 22 patients with superficial subcutaneous RDD. The lesions presented papules nodules, often discoloration (9/22) frequent multifocality (13/22), without predilection for specific site the body. Age distribution was wide ranged from 15 to 68 years, median 43.5 years....
This review provides a comprehensive overview of the broad clinicopathologic spectrum cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in older literature such as anaplastic telangiectatic KS, well several lymphedematous variants; numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like,...
Primary cutaneous apocrine carcinoma is a rare malignancy. This study of 24 examples suggests that the prognosis not always poor and grading criteria devised for breast may have utility in this group malignancies. Furthermore, steroid receptor expression should be investigated these tumors, particularly if tumor unlikely to controlled by surgery alone.
The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2). Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had solitary neoplasm (size 2.2 17.5 cm; median 4 cm), whereas the remaining 5 (4 1 male; 66 72 manifested clinical features Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, on which background larger lesions appeared....
Abstract: Mutations in β‐catenin are present benign pilomatrixomas. is a downstream effector the WNT‐signalling pathway, acting as signal for differentiation and proliferation. CTNNB1 , gene encoding β‐catenin, wide variety of malignant neoplasms. We examined series pilomatrix carcinomas (15 cases) by using immunohistochemistry DNA sequencing exon 3 from compared these to pilomatrixomas (13 cases). All 11 available examination showed nuclear localization mutations similar those demonstrated...
Cutaneous sebaceous neoplasia is known to exhibit a high degree of DNA mismatch repair (MMR) deficiency leading microsatellite instability and these tumors can be markers the Muir-Torre syndrome internal malignancy. Other tumors, such as colonic carcinoma, show tendencies toward particular histologic features sites involvement correlating with MMR deficiency. There are few comprehensive studies unselected cutaneous neoplasms. To address this gap in knowledge, we examined 94 neoplasms from 92...
Carcinosarcomas (malignant Müllerian mixed tumors [MMMTs]) of the uterine cervix are rare neoplasms. This report describes morphology, immunohistochemical profiles, and human papillomavirus (HPV) status eight cervical MMMTs. Patients' ages ranged from 32 to 93 years (mean, 61 years). Seven cases showed in situ squamous cell carcinoma (SCC). The invasive epithelial component (EC) was composed combined adenoid basal carcinoma, basaloid SCC, cystic (ACC) two cases. Keratinizing large...
Adenoid cystic carcinomas (ACCs) and adenoid basal (ABCs) are rare neoplasms of the uterine cervix that currently regarded as distinct clinicopathologic entities. Accurate distinction between ABCs ACCs is clinical importance because differences in their biological behavior. This study compares morphologic, mucin, immunohistochemical profiles 18 cervical ACCs, 8 ABCs, 1 combined ABC-ACC. Serial sections from 27 cases were stained with hematoxylin eosin, periodic acid-Schiff-diastase,...
Mucinous carcinoma may present at various sites, including the breast and gastrointestinal tract. Rarely, such tumors arise within skin. Comparatively, lesions are relatively common usually associated with a good prognosis. When pure, they typically estrogen (ER) progesterone receptor (PR) positive responsive to tamoxifen. The authors studied 12 mucinous carcinomas of skin compared morphology that typical mammary lesions. also evaluated for expression receptor, mucus-associated peptides...
Aim: To investigate the role of human papillomavirus (HPV) in large cell neuroendocrine carcinoma (LCNEC) uterine cervix.Methods: Twelve archival, immunohistochemically and/or electron microscopically confirmed cases cervical LCNEC were studied.Non-isotopic situ hybridisation (NISH) was performed on formalin fixed, paraffin wax embedded biopsies using digoxigenin labelled probes to HPV types 6, 11, 16, 18, 31, and 33.The tumours then subjected polymerase chain reaction (PCR) analysis...
Squamous differentiation in eccrine porocarcinoma (EPC) is an unusual phenomenon that has rarely been reported the literature. This study describes clinical and pathological findings a series of 21 cases EPC showing extensive squamous differentiation.The H&E-stained sections, epithelial membrane antigen carcinoembryonic immunohistochemical stains were reviewed for each case. The following variables examined: age, gender, race, site size EPC. prevalence other cutaneous lesions and/or...
Background: Kaposi sarcoma (KS) is a low-grade angioproliferative neoplasm derived from lymphatic endothelium. Lesions progress early patch stage into plaques that ultimately form tumor nodules. Several histological variants of KS have been described. The aim this study to describe 5 new histopathologic cutaneous KS. Method: Skin biopsy material submitted South African dermatopathology practice diagnostic was reviewed. Formalin-fixed, paraffin-embedded tissue routinely processed and stained...
Rosai-Dorfman disease (RDD), previously known as sinus histiocytosis with massive lymphadenopathy, is a benign, idiopathic histiocytic proliferative disorder. It commonly affects lymph nodes, but any organ of the body may be involved. Histological findings include characteristic large, pale, cells (Rosai-Dorfman cells) exhibiting cytophagocytosis. Immunohistochemically, these histiocytes are positive for S-100 protein and CD68, stain negatively CD1a. On electron microscopy, Birbeck granules...
AIM: To investigate the role of human papillomavirus (HPV) in adenoid cystic carcinoma uterine cervix. METHODS: Eleven archival, paraffin wax embedded specimens were analysed by non-isotopic situ hybridisation (NISH) for HPV types 6, 11, 16, 18, 31, and 33 using digoxigenin labelled probes. The polymerase chain reaction (PCR) was carried out on each cases consensus primers to HPV. RESULTS: A total eight carcinomas harboured genome NISH, which five PCR positive. Integrated 16 DNA demonstrated...
Chronic infection with hepatitis B virus (HBV) remains a problem of global significance and improving available treatment is important to prevent life-threatening complications arising in persistently infected individuals. HBV susceptible silencing by exogenous artificial intermediates the RNA interference (RNAi) pathway. However, toxicity Pol III cassettes short duration effectors RNAi pathway may limit anti-HBV therapeutic utility. To advance RNAi-based gene silencing, mono- trimeric...
A large percentage of patients with HIV/AIDS will develop dermatological complications. Consequently, all practising clinicians and pathologists in regions a high prevalence must be familiar the diverse cutaneous manifestations disease. This paper highlights fact that biopsy material this clinical context may occasionally reveal more than one pathological process. The potential spectrum includes two or infections single skin (e.g., herpes simplex cytomegalovirus infection), neoplastic...