A5039917618- Ocular Surface and Contact Lens
- Otitis Media and Relapsing Polychondritis
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Colorectal Cancer Surgical Treatments
- Intraocular Surgery and Lenses
- Salivary Gland Disorders and Functions
- Glaucoma and retinal disorders
- Dental Anxiety and Anesthesia Techniques
- Anesthesia and Sedative Agents
- Laser Applications in Dentistry and Medicine
- Corneal Surgery and Treatments
- Inflammation biomarkers and pathways
University of Leeds
2024
NIHR Leeds Musculoskeletal Biomedical Research Unit
2024
St James's University Hospital
2024
Kresge Eye Institute
1998-2008
The University of Texas Health Science Center at Houston
1998
Atrium Health Wake Forest Baptist
1998
St. John Medical Center
1998
Scripps Health
1998
Scripps Clinic
1998
Penn Presbyterian Medical Center
1998
ABSTRACT The apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is crucial for inflammasome assembly and activation of several inflammasomes, including NLRP3. ASC aggregates are detected in human sera post pyroptotic cell death, but their origin remains unclear. This study aimed to develop method detect originating from NLRP3 inflammasomes. Initially, monocytes, macrophages, THP-1 reporter cells were employed validate the detection ASC/NLRP3-positive events...
Objective Adult‐onset Still disease (AOSD) is a systemic autoinflammatory disorder (AID) of unknown etiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis large cohort with AOSD to investigate the underlying pathology identify novel targets for potential treatment. Methods We investigated cases (n = 60) rare germline somatic variants using whole exome sequencing virtual gene panels. Transcriptome profiles were by bulk RNA blood....