A5067251673- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Blood disorders and treatments
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Glycosylation and Glycoproteins Research
- Ocular Surface and Contact Lens
- Intestinal and Peritoneal Adhesions
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Oral microbiology and periodontitis research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Tumors Diagnosis and Treatment
- Vasculitis and related conditions
- Nitric Oxide and Endothelin Effects
- Intraperitoneal and Appendiceal Malignancies
- Corneal Surgery and Treatments
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Legionella and Acanthamoeba research
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
University Medical Centre Mannheim
2023-2025
Heidelberg University
2023-2025
University Hospital Heidelberg
2023-2025
Universitätsklinikum Erlangen
2016-2024
University Medical Center
2024
German Climate Computing Centre
2020
Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger in COVID-19 are incompletely understood.
Neoplasms with a myopericytomatous pattern represent morphological spectrum of lesions encompassing myopericytoma the skin and soft tissue, angioleiomyoma, myofibromatosis/infantile haemangiopericytoma putative neoplasms reported as malignant myopericytoma. Lack reproducible phenotypic genetic features myopericytic have prevented establishment sarcoma an acceptable diagnostic category. Following detection LMNA-NTRK1 gene fusion in index case paediatric haemangiopericytoma-like by combined...
Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution inflammation are incompletely characterized. Nanoparticles known to induce plasma membrane damage and necrosis followed by sterile inflammation. We observed that injection metabolically inert nanodiamonds resulted in paw edema WT Ncf1** mice. However, while quickly resolved mice, it persisted over several weeks mice...
In response to various infectious and sterile stimuli neutrophils release chromatin decorated with bactericidal proteins, referred as NETs. Their scaffolds are formed from fibers which display an apparent diameter of 15–17 nm mainly consist DNA (2 nm) DNA-associated histones (11 nm). The NET-forming strands thus not naked but higher ordered structures. may be released the NET, especially if their tail arginines have been citrullinated. Several studies indicate that extracellular toxic for...
Phagocytosis, degranulation, and neutrophil extracellular traps (NETs) formation build the armory of neutrophils for first line defense against invading pathogens. All these processes are modulated by microenvironment including tonicity, pH oxygen levels. Here we investigated infiltration in cardiac tissue autopsy samples patients with acute myocardial infarction (AMI) compared tissues from sepsis, endocarditis, dermal inflammation, abscesses diseases prominent infiltration. We observed many...
A better understanding of the function neutrophil extracellular traps (NETs) may facilitate development interventions for sepsis. The study aims to investigate formation and degradation NETs in three murine sepsis models analyze production reactive oxygen species (ROS) during NET formation. Murine was induced by midgut volvulus (720° 15 min), cecal ligation puncture (CLP), or application lipopolysaccharide (LPS) (10 mg/kg body weight i.p.). modulated using mice that were genetically...
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Neutrophils operate as part of the innate defence in skin and may eliminate Borrelia spirochaete via phagocytosis, oxidative bursts, hydrolytic enzymes. However, their importance Lyme neuroborreliosis (LNB) is unclear. Neutrophil extracellular trap (NET) formation, which associated with production reactive oxygen species, involves extrusion neutrophil DNA to form traps that incapacitate bacteria immobilise viruses. Meanwhile, NET formation has recently been studied pneumococcal meningitis,...
Salivary gland stones, or sialoliths, are the most common cause of obstruction salivary glands. The mechanism behind formation sialoliths has been elusive. Symptomatic sialolithiasis a prevalence 0.45% in general population, is characterized by recurrent painful periprandial swelling affected gland, and often results sialadenitis with need for surgical intervention. Here, we show use immunohistochemistry, immunofluorescence, computed tomography (CT) scans reconstructions, special dye...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to an adaptive immune response in the host and formation of anti-SARS-CoV-2 specific antibodies. While IgG responses against SARS-CoV-2 have been characterized quite well, less is known about IgA. IgA2 activates cells induces inflammation neutrophil extracellular trap (NET) which may contribute organ injury fatal outcome SARS-CoV-2-infected patients. spike protein antibody levels were measured plasma samples 15...
Abstract The release of neutrophil extracellular traps (NETs) is one the weapons neutrophils have in their armory. NETs consist chromatin fibers decorated with a plethora cytoplasmic and granular proteins, such as antimicrobial serine protease elastase (NE). Because first description beneficial to host, reports on double-faced role health disease considerably increased recently. On hand, reportedly trap kill bacteria also participate resolution acute inflammation associated infection tissue...