A5055518270- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoparticle-Based Drug Delivery
- Intestinal and Peritoneal Adhesions
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Pharmacological Receptor Mechanisms and Effects
- Muscle and Compartmental Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intraperitoneal and Appendiceal Malignancies
- Neuropeptides and Animal Physiology
- Inflammasome and immune disorders
University Medical Centre Mannheim
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Nantong University
2021-2024
Affiliated Hospital of Nantong University
2023-2024
Second Affiliated Hospital of Luohe Medical College
2021
A better understanding of the function neutrophil extracellular traps (NETs) may facilitate development interventions for sepsis. The study aims to investigate formation and degradation NETs in three murine sepsis models analyze production reactive oxygen species (ROS) during NET formation. Murine was induced by midgut volvulus (720° 15 min), cecal ligation puncture (CLP), or application lipopolysaccharide (LPS) (10 mg/kg body weight i.p.). modulated using mice that were genetically...
Kidney fibrosis is the common final pathway of chronic kidney disease (CKD), and it distinguished by inflammation, mesenchymal transition with myofibroblast formation, epithelial-to-mesenchymal (EMT). Macrophages are protuberant inflammatory cells in kidney, their roles dependent on phenotypes. However, remains unclear whether tubular epithelial (TECs) undergoing EMT can influence phenotypes macrophages underlying mechanisms during development fibrosis. Here, we investigated characteristics...
Renal fibrosis is the pathological outcome of most end-stage renal diseases, yet there are still limited therapeutic options for it. In recent years, bone marrow mesenchymal stem cell-derived exosomes (BM-MSCs) have received much attention. Here, we investigate effect BM-MSCs on unilateral ureteral occlusion (UUO)-induced interstitial in kidney by modulating prostaglandin E2 receptor 2 (EP2). changes were evident UUO group compared to control group, with significantly increased expression...
Abstract Sepsis‐associated acute kidney injury (AKI) has high morbidity and mortality, but without cause‐specific treatment. Erythropoietin derived Helix B surface peptide (HBSP) alleviates AKI, whereas its underlying mechanisms remain to be further explored. Here, the effects of HBSP on pyroptosis, apoptosis, macrophage polarization repair were investigated in lipopolysaccharide (LPS)‐induced AKI mouse model cultured epithelial cells. Systemic inflammation, compromised renal function...