A5046418192- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Respiratory Health Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tracheal and airway disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Congenital gastrointestinal and neural anomalies
- Hernia repair and management
- Neuroblastoma Research and Treatments
- Neonatal and Maternal Infections
- Appendicitis Diagnosis and Management
- Urological Disorders and Treatments
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Injury Epidemiology and Prevention
- Gastrointestinal disorders and treatments
- Burn Injury Management and Outcomes
- Intestinal and Peritoneal Adhesions
- Infant Nutrition and Health
- Testicular diseases and treatments
- Intraperitoneal and Appendiceal Malignancies
- Immune Cell Function and Interaction
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Kinderkrebs-Zentrum Hamburg
2022-2025
Martini-Klinik
2024
University Hospital Carl Gustav Carus
2024
TU Dresden
2024
University Hospital Cologne
2024
University of Cologne
2024
Pediatric Oncology Group
2022
Altonaer Kinderkrankenhaus
2013-2021
To test the clinical and sonographic predictors of testicular torsion (TT) with aim reducing negative exploration rates.We performed a prospective study all boys treated for 'acute scrotum' at our institute between January 2001 April 2012 findings were documented. If available, ultrasonography (US) was added to diagnostic evaluation. A prediction diagnosis based on features, followed by surgical in patients.A total 104 patients included 16-month period study. No single finding excluded TT....
Background Neutrophils are the first responders in wound healing after injury that mediate pro- and anti-inflammatory activities i.a. through formation of extracellular traps (NETs). However, excessive NETs presence tissue can cause local hyperinflammation -coagulation resulting delayed healing. To improve healing, we aimed to examine role DNase1 on primary secondary Methods The study included 93 C57BL/6 mice, with 3 different genotypes: wildtype, Pad4-, DNase1-Knockout (KO). Pad4-KO mice...
Objective: To systematically investigate the impact of location defect in congenital diaphragmatic hernia on neonatal mortality and morbidity with a special focus survival at discharge, extracorporeal membrane oxygenation requirement, development chronic lung disease. Design: Retrospective tertiary care center study matched-pair analysis all fetuses that were treated for between 2004 2009. Setting: A specialized hernia. Patients: Complete sets data available 106 patients For 17 18 infants...
Abstract Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition kinetics of NK intestine during first year life, when infants broadly exposed to exogenous antigens, still unclear. Here we show that CD103 + major ILC population small intestines infants. When compared adult intestinal infant exhibit a robust effector phenotype, characterized by Eomes, perforin granzyme B expression, superior degranulation...
A better understanding of the function neutrophil extracellular traps (NETs) may facilitate development interventions for sepsis. The study aims to investigate formation and degradation NETs in three murine sepsis models analyze production reactive oxygen species (ROS) during NET formation. Murine was induced by midgut volvulus (720° 15 min), cecal ligation puncture (CLP), or application lipopolysaccharide (LPS) (10 mg/kg body weight i.p.). modulated using mice that were genetically...
Abstract Background Predicting burn-related mortality is vital for family counseling, triage, and resource allocation. Several of the burn-specific prediction scores have been developed, including Abbreviated Burn Severity Index (ABSI) in 1982. However, these are not tested accuracy to support contemporary estimates global burden burn injury. This study compares across countries with varying economic levels, as indicated by Human Development (HDI), assess if a modified ABSI (mABSI) offers...
In this single-center retrospective analysis, we present case data and insights gathered over the past eight years. Additionally, computed postnatal, pre-therapy lesion-to-lung ratios of Congenital Pulmonary Airway Malformations (CPAMs) to retrospectively assess potential outcome prediction using ratios. Data were collected between 2015 2022. Information such as chosen therapy, surgical duration, postoperative hospital stay, follow-up was obtained from electronic records. Pre-therapy...
(1) Background: In children, bacterial pneumonia is the most common cause of parapneumonic pleural effusions which can eventually lead to empyema. Treatment varied and a combination antibiotic therapy, chest tube drainage, fibrinolytics video-assisted thoracoscopic surgery (VATS). Postoperative complications latter include pneumothoraces bronchopleural fistula (BPF). The aim this study investigate incidence duration during perioperative period follow-up (FU) elucidate their progression...
Abstract This study aimed to assess the risk factors for complications post-Tenckhoff catheter implantation in paediatric patients. All records of children who underwent procedure from 2002 2022 at University Medical Centre Hamburg were analyzed. The demographic and anthropometric characteristics scrutinized, with particular attention given such as leakage, occlusions, peritonitis. Univariate multivariate analyses employed determine hazard ratios complications. In total, 299 implantations...
Abstract Duplications of the gastrointestinal tract exist in various forms and present differently depending on their location. They are extremely rare congenital malformations, especially duplication cysts pyloric channel among rarest. appear with a variety symptoms, above all severe vomiting. To date surgical resection seems to be only effective treatment. In order share our experience gastric cyst, we case 36-day-old girl.
Abstract Thrombosis and inflammation cooperate in the development of intestinal infarction. Recent studies suggest that extracellular DNA released by damaged cells or neutrophils form traps (NETs) contributes to organ damage experimental models ischemia-reperfusion injury. Here we compared therapeutic effects targeting fibrin infarction after midgut volvulus rats. Following iatrogenic induction for 3 hours, treated animals with a combination tissue plasminogen activator (tPA) low molecular...
Necrotizing enterocolitis (NEC) is one of the most devastating diseases affecting premature and mature infants. It hypothesized that NEC result neutrophils' active role in hyperinflammation after bacterial gut colonization, through their nuclear DNA release formation neutrophil extracellular traps (NETs) to combat pathogens. The aim this study was evaluate importance NETs pathogenesis, as well identify validate markers NETosis predict NEC. induced mice by gavage feeding Neocate...
An early and accurate diagnosis of onset neonatal sepsis (EONS) late (LONS) is essential to improve the outcome this devastating conditions. Especially, preterm infants are at risk. Reliable biomarkers rare, clinical decision-making depends on appearance multiple laboratory findings. Markers NET formation turnover might diagnostic precision. Aim study was evaluate value NETs in infants.Plasma samples with suspected were collected. Blood assayed for markers turnover: cfDNA, DNase1,...
Abstract Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation Latent Disease) Study is a prospective cohort study designed identify follow up their household contacts infected in early 2020 first wave SARS-CoV-2. We screened 6113 < 18 by nasopharyngeal swab-PCR low-incidence setting after general lockdown,...
Adequate patient volume is essential for the maintenance of quality, meaningful research, and training next generation pediatric surgeons. The role university hospitals to fulfill these tasks at highest possible level. Due decentralization surgical care during last decades, there a trend toward reduction operative caseloads. aim this study was assess most relevant congenital malformations German academic institutions over past years. Nineteen chairpersons representing university-chairs in...
Background & AimsUlcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, associated with specific risk single nucleotide polymorphisms in HLA class II. Given recently discovered interactions between subsets HLA-DP molecules activating natural killer (NK) cell receptor NKp44, genetic associations UC haplotypes their functional implications were investigated.MethodsHLA-DP haplotype association analyses performed (UC: n = 13,927; control:...