Freya Sibbertsen
A5045793553- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Immune responses and vaccinations
- SARS-CoV-2 detection and testing
- PI3K/AKT/mTOR signaling in cancer
- Single-cell and spatial transcriptomics
- Prostate Cancer Treatment and Research
- Bone health and treatments
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
Universität Hamburg
2021-2023
University Medical Center Hamburg-Eppendorf
2021-2023
Abstract Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation Latent Disease) Study is a prospective cohort study designed identify follow up their household contacts infected in early 2020 first wave SARS-CoV-2. We screened 6113 < 18 by nasopharyngeal swab-PCR low-incidence setting after general lockdown,...
SARS-CoV-2 is still a major burden for global health despite effective vaccines. With the reduction of social distancing measures, infection rates are increasing in children, while data on pediatric immune response to lacking. Although typical disease course children has been mild, emerging variants may present new challenges this age group. Peripheral blood mononuclear cells (PBMC) from 51 convalescent 24 seronegative siblings early 2020, and unexposed controls were stimulated with...
Bone metastases frequently occur in breast cancer patients and lack appropriate treatment options. Hence, understanding the molecular mechanisms involved multistep process of bone metastasis tumor-induced osteolysis is paramount interest. The serine/threonine kinase AKT plays a crucial role but effect individual isoforms remains unclear. Therefore, isoform-specific knockdowns were generated on bone-seeking MDA-MB-231 BO subline proliferation, migration, invasion, chemotaxis was analyzed by...
The situation of limited data concerning the response to COVID-19 mRNA vaccinations in immunocom-promised children hinders evidence-based recommendations. This prospective observational study investigated humoral and T cell responses after primary BNT162b2 vaccination secondary immunocompromised healthy aged 5–11 years. Participants were categorized as: kidney transplantation (KTx, n = 9), proteinuric glomerulonephritis (GN, 4) (controls, 8). Expression activation-induced markers cytokine...
Pediatric SARS-CoV-2 infection is often mild or asymptomatic and the immune responses of children are understudied compared to adults. Here, we present evaluate performance a two-panel (16- 17 parameter) flow cytometry-based approach for phenotypic analysis cryopreserved PBMC samples from after infection. The panels were optimized based on previous related studies pediatric system. seven seropositive early 2020 five age-matched healthy controls stained T-cells (panel T), B innate cells B)....
Abstract SARS-CoV-2 is still a major burden for global health despite effective vaccines. With the reduction of social distancing measures, infection rates are increasing in children, while data on pediatric immune response to lacking. Although typical disease course children has been mild, emerging variants may present new challenges this age group. Peripheral blood mononuclear cells (PBMC) from 51 convalescent 24 seronegative siblings early 2020, and unexposed controls were stimulated with...
Abstract Almost two years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation Latent Disease) Study is a prospective cohort study designed identify follow up their household contacts infected in early 2020 first wave SARS-CoV-2. We screened 6113 <18 by nasopharyngeal swab-PCR low-incidence setting after general...