A5039186600- Hip disorders and treatments
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Orthopaedic implants and arthroplasty
- Pregnancy-related medical research
- Orthopedic Infections and Treatments
- Sports injuries and prevention
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Bone fractures and treatments
- Foot and Ankle Surgery
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Abdominal Trauma and Injuries
- Orthopedic Surgery and Rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Trauma and Emergency Care Studies
- Cancer, Hypoxia, and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Polyamine Metabolism and Applications
BG Klinikum Hamburg
2022-2024
University Medical Center Hamburg-Eppendorf
2019-2024
Universität Hamburg
2019-2024
Circulating tumor cells (CTCs) are shed from the primary into bloodstream. While many studies on solid exist, data CTCs scarce. The mortality of cancer is mostly associated with metastasis and recent research identified as initiators metastasis. PI3K/AKT/mTOR signaling pathway an intracellular that regulates essential functions including protein biosynthesis, cell growth, cycle control, survival migration. Importantly, activating oncogenic mutations amplifications in this frequently observed...
Abstract Introduction Traditionally, plate osteosynthesis of the anterior column combined with an antegrade posterior screw is used for fixation plus hemitransverse (ACPHT) acetabulum fractures. Replacing infraacetabular could improve straightforwardness surgery, as it can be inserted using less invasive approaches, such AIP/Stoppa approach, which a well-established standard approach. However, biomechanical stability instead unknown. Material and methods Two constructs were compared in...
Bone metastases frequently occur in breast cancer patients and lack appropriate treatment options. Hence, understanding the molecular mechanisms involved multistep process of bone metastasis tumor-induced osteolysis is paramount interest. The serine/threonine kinase AKT plays a crucial role but effect individual isoforms remains unclear. Therefore, isoform-specific knockdowns were generated on bone-seeking MDA-MB-231 BO subline proliferation, migration, invasion, chemotaxis was analyzed by...
Bone stress injuries (BSIs) are common sports that occur because of an imbalance between microdamage accumulation and removal through bone remodeling. The underlying phenotype has been assumed to be a contributing factor. However, the microarchitecture athletes with BSI is not well characterized, no study investigated whether impaired associated composition or anatomic site injury.This cross-sectional characterizes at distal radial tibial reference locations in BSI. Based on previous...
Dynamization of proximal femoral nailing by removal distal interlocking is one the recommended treatment options for nonunions femur fractures. However, in certain inter-/subtrochanteric fractures, gliding nail along shaft blocked lateral cortical support lag screw. For these cases, Biber et al. proposed notching (LCN), which supporting bone removed. This study investigates biomechanical effect LCN on and stress distribution at bone/implant interface.In this finite element analysis a...
The management of periprosthetic joint infection (PJI) remains a major challenge in orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure and metabolism clinical cohort patients with chronic PJI.Periprosthetic femoral trabecular specimens were obtained from suffering PJI hip knee (n = 20). Microbiological analysis was performed on preoperative aspirates tissue during revision Microstructural cellular parameters analyzed by histomorphometry undecalcified...
Short stems are a valuable option in young patients undergoing total hip arthroplasty (THA) because of their bone stock preserving properties facilitating revision arthroplasty. Although the effect obesity on conventional THA is well studied, data about short stem obese lacking. Therefore, this study aimed to investigate influence complications, revisions, and outcome after THA.
Abstract Purpose Addressing grade 2 and 3 medial‐sided instabilities during anterior cruciate ligament (ACL) reconstruction is crucial to reduce the risk of ACL graft failure. This study introduced a minimally invasive, medial collateral (MCL) augmentation technique using peroneus longus split tendon autograft, which was fixed femoral deep MCL insertion tibial superficial insertion. Methods prospective, longitudinal, single‐centre case series included patients who underwent concurrent with...
Background: Short-stem total hip arthroplasty (THA) has gained popularity due to its bone-sparing technique, but outcomes in patients with obesity remain uncertain. The aim of this study was investigate the impact on postoperative subsidence and clinical after short-stem THA. Methods: A retrospective cohort a minimum follow-up 24 months conducted 163 who underwent THA collarless, triple-tapered, cementless stem achieving fixation metaphyseal region. Patients were categorized into (Body Mass...
Bekannt ist, dass Beckenring- und Acetabulumfrakturen im Rahmen von Arbeitsunfällen neben langen Arbeitsunfähigkeitszeiten auch mit einer hohen Rate an Minderungen der Erwerbsfähigkeit (MdE) sowie Kosten für Renten/Abfindungen einhergehen. Untersuchung Änderungen Rentenleistungen 2013 bis 2019 nach isolierten in Deutschland. Für alle Patienten aus dem Register Deutschen Gesetzlichen Unfallversicherung (DGUV) isolierter oder Acetabulumfraktur eines Arbeitsunfalls wurden lineare Trendanalysen...
To analyse the results after tibial plateau fractures with a focus on socioeconomic consequences.On basis of data from rehabilitation documentation German Statutory Accident Insurance (DGUV) (Code 83), retrospective anonymised evaluation injuries which occurred in 2010 and 2016 was carried out. The registry allowed subdivision into 3 groups: Medial, lateral bicondylar fractures. have been analysed regard to following parameters: age, gender, treatment, time return work (AU), costs per case,...
Traumatic or iatrogenic sciatic nerve injury, but not superior gluteal is a well described complication after acetabular fractures. Most often, injuries occur in fractures involving the posterior column/wall with hip dislocation and fracture displacement resulting narrowing of greater foramen injuring passing through. In this case report, abductor mechanism deficiency positive Trendelenburg's sign an column presented. Postoperative clinical MRI examination revealed neurogenic atrophy gluteus...