A5079754201- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Immune cells in cancer
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Viral Infectious Diseases and Gene Expression in Insects
- Cutaneous Melanoma Detection and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Dermatology and Skin Diseases
- Polyomavirus and related diseases
- Complement system in diseases
- Bioinformatics and Genomic Networks
- Bacteriophages and microbial interactions
- T-cell and B-cell Immunology
- Signaling Pathways in Disease
- Plant Virus Research Studies
- Breast Lesions and Carcinomas
- Calcium signaling and nucleotide metabolism
- Advancements in Transdermal Drug Delivery
Universitätsklinikum Erlangen
2019-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2025
Freie Universität Berlin
2025
German Climate Computing Centre
2020-2024
Comprehensive Cancer Center Erlangen
2020-2022
The bone marrow niche has a pivotal role in progression, survival, and drug resistance of multiple myeloma cells. Therefore, it is important to develop means for targeting the microenvironment. Myeloma-associated macrophages (MAM) are M2 like. They provide nurturing signals cells promote immune escape. Reprogramming M2-like toward tumoricidal M1 phenotype represents an intriguing therapeutic strategy. This especially interesting view successful use mAbs against cells, as these therapies hold...
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light the simultaneous intracellular adaptation bacteria changes in proteome phagocytes response internalization C. . Quantitative analyses were carried out at different time points an infection assay data analyzed by bioinformatic approaches. Several proteins, which not observed or connected pathogenicity before,...
Summary Background Left dorsal displacement of the large colon (LDDLC) is a common type colic in horses. Different risk factors for developing LDDLC have already been established. To prevent recurrence pathology, multiple laparoscopic nephrosplenic space closing techniques developed. However, correlation between configuration (NSS), which visible through laparoscopy, and has not examined. Objectives examine whether NSS configuration, among other possible factors, correlated with development...
Dendritic cells (DCs) are professional antigen-presenting that induce and regulate adaptive immunity by presenting antigens to T cells. Due their coordinative role in immune responses, DCs have been used as cell-based therapeutic vaccination against cancer. The capacity of a response can be enhanced re-wiring cellular signalling pathways with microRNAs (miRNAs). Methods: Since the activation maturation is controlled an interconnected network, we deploy approach combines RNA sequencing data...
Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant rational antigen selection pipeline would lay the foundation immunotherapy trials with potential enhance treatment, tremendously benefiting patients suffering from rare, understudied cancers. We present experimentally validated, data-driven computational that selects ranks in multipronged approach....
Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors. However, the selection of promising candidates from total quantity possible epitopes poses a challenge to clinicians and bioinformaticians alike, very few have tested experimental or clinical settings validate their efficacy. Here, we present comprehensive database predicted nonmutated peptide derived genes that are overly expressed group 32 melanoma biopsies compared with healthy tissues were...
Merkel cell carcinoma (MCC) is a rare and highly aggressive cancer, which mainly caused by genomic integration of the polyomavirus subsequent expression truncated form its large T antigen. The resulting primary tumor known to be immunogenic under constant pressure escape immune surveillance. Because interferon gamma (IFNγ), key player response, secreted many effector cells has been shown exert both anti-tumoral pro-tumoral effects, we studied transcriptomic response MCC IFNγ. In particular,...
e21024 Background: Other than cutaneous melanoma, metastatic uveal melanoma (UM) is minimally responsive to checkpoint inhibitors. The prognosis remains very poor with mortality rates nearly unchanged over the last decades. recently growing insight that immunotherapy significantly improves outcomes for cancer patients led a re-emergence of vaccines including dendritic cell (DC) vaccines. Methods: We vaccinated an UM patient in compassionate use setting and assessed immunological clinical...
Abstract Dendritic cells (DCs) are professional antigen-presenting that induce and regulate adaptive immunity by presenting antigens to T cells. Due their coordinative role in immune responses, DCs have been used as cell-based therapeutic vaccination against cancer. The capacity of a response can be enhanced re-wiring cellular signalling pathways with microRNAs (miRNAs). Since the activation maturation is controlled an interconnected network, we deploy approach combines RNA sequencing data...
Abstract Tumor-associated antigens (TAAs) and their derived peptides constitute the chance to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. Here, we present computational pipeline that selects ranks candidate in multi-pronged approach applied it case uveal melanoma. In addition antigen expression tumor target healthy tissues, incorporated network analysis-derived indispensability index motivated by modeling results, immunogenicity...
<div>Abstract<p>Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors. However, the selection of promising candidates from total quantity possible epitopes poses a challenge to clinicians and bioinformaticians alike, very few have tested experimental or clinical settings validate their efficacy. Here, we present comprehensive database predicted nonmutated peptide derived genes that are overly expressed group 32 melanoma biopsies compared...
<p>Contains further information on raw data, its sources and processing (NGS pipeline, tissue lists selection). We also provide supporting the selected genes their expression patterns in relevant tissues.</p>
<p>Contains further information on raw data, its sources and processing (NGS pipeline, tissue lists selection). We also provide supporting the selected genes their expression patterns in relevant tissues.</p>