A5077009005- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Neurological disorders and treatments
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Genetic Neurodegenerative Diseases
- Neuroendocrine Tumor Research Advances
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Amino Acid Enzymes and Metabolism
- Cancer Diagnosis and Treatment
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Ludwig-Maximilians-Universität München
2025
Heidelberg University
2023
Heidelberg University
2023
Bayer (Germany)
2022
Klinik und Poliklinik für Nuklearmedizin
1996-2021
Forschungszentrum Jülich
1987-2019
Hudson Institute
2017
John Wiley & Sons (United States)
2017
Interpretation of dobutamine stress echocardiography (DSE) is subjective and strongly dependent on the skills reader. Strain-rate imaging (SRI) by tissue Doppler may objectively analyze regional myocardial function. This study investigated SRI markers stress-induced ischemia analyzed their applicability in a clinical setting.DSE was performed 44 patients with known or suspected coronary artery disease. Simultaneous perfusion scintigraphy served as "gold standard" to define ischemia. All...
The radionuclide bone scan is the cornerstone of skeletal nuclear medicine imaging. Bone scintigraphy a highly sensitive diagnostic imaging technique that uses radiotracer to evaluate distribution active formation in skeleton related malignant and benign disease, as well physiological processes. European Association Nuclear Medicine (EANM) has written approved these guidelines promote use procedures high quality. present offer assistance practitioners optimizing procedure interpreting...
Objectives To date, there is no valuable tool to assess fibrotic disease activity in humans vivo a non-invasive way. This study aims uncouple inflammatory from fibroinflammatory diseases such as IgG 4 -related disease. Methods In this cross-sectional clinical study, 27 patients with inflammatory, and overlapping manifestations of underwent positron emission tomography (PET) scanning tracers specific for fibroblast activation protein (FAP; 68 Ga-FAP inhibitor (FAPI)-04), 18...
In this study the regional cerebral glucose utilization and neuropsychological performance of patients with amyotrophic lateral sclerosis (ALS) was investigated. Special attention given to tests thought mirror frontal lobe dysfunction. The studied in 18 using high-resolution positron emission tomography. Clinically all displayed upper lower motor neurone signs. ALS metabolism significantly reduced entire cortex compared controls; no changes were seen cerebellum. Comprehensive assessment a...
In 23 patients with moderate to severe Huntington's disease (HD) and 21 normal volunteers, the regional cerebral metabolic rate of glucose consumption (rCMRGlc) was measured in cerebellum, thalamus, striatum, cortex using positron emission tomography 18F-deoxyglucose method. contrast previous reports, rCMRGlc reduced not only but also HD as compared subjects. No significant difference between subjects found for thalamic cerebellar rCMRGlc. To investigate relationship clinical status rCMRGlc,...
We present a calibration method of clinical SPECT/CT device for quantitative <sup>99m</sup>Tc SPECT. use commercially available reconstruction package including ordered-subset expectation maximization (OSEM) with depth-dependent 3-dimensional resolution recovery (OSEM-3D), CT-based attenuation correction, and scatter correction. validated the in phantom studies applied it to images from patients injected <sup>99m</sup>Tc-diphosponate. <b>Methods:</b> The following 3 steps were performed...
The purpose of this study was to determine the diagnostic value 131I SPECT/spiral CT (SPECT/CT) on nodal staging patients with thyroid carcinoma at first ablative radioiodine therapy.Fifty-seven were studied using SPECT/CT 3-4 d after receiving 3.96+/-0.5 GBq for radioablation remnants a thyroidectomy differentiated carcinoma. In addition planar whole-body scintigraphy, neck performed hybrid camera combining double-head SPECT either 2-slice (n=23) or 6-slice (n=34) spiral scanner. scans and...
Fever of unknown origin (FUO) and inflammation (IUO) are diagnostically challenging conditions. Diagnosis underlying disease may be improved by 18F-fluorodesoxyglucose positron emission tomography (18F-FDG-PET).Prospective study to test diagnostic utility 18F-FDG-PET/CT in a large cohort patients with FUO or IUO define parameters that increase the likelihood 18F-FDG-PET/CT. Patients received scanning addition standard work-up. results were classified as helpful non-helpful establishing final...
Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of various types cancers. <sup>68</sup>Ga-labeled chelator-linked FAP inhibitors (FAPIs) have been successfully applied to PET tumor types. To broaden spectrum applicable tracers for extended studies FAP-dependent diseases, we herein report radiosynthesis preclinical evaluation <sup>18</sup>F-labeled glycosylated FAPI ([<sup>18</sup>F]FGlc-FAPI). <b>Methods:</b> An...
Attenuation correction of positron emission tomographic (PET) data is critical in providing accurate and quantitative PET volumes. Deriving an attenuation map (μ-map) from magnetic resonance (MR) volumes a challenge PET/MR hybrid imaging. The difficulty lies differentiating cortical bone air standard MR sequences because both these classes yield little to no signal thus shows distinguishable information. objective this contribution 2-fold: (1) generate evaluate continuous valued computed...
Routine single-photon emission computed tomography (SPECT) currently lacks quantitative information on regional activity concentration (ACC) of the injected tracer (e.g. kBq/ml). Furthermore, little is known skeletal absolute 99mTc-DPD after intravenous injection in bone scintigraphy. The aim this study to determine ACC healthy lumbar vertebrae patients using a recently published SPECT/computed (CT) protocol. Lumbar estimates were performed 50 female (mean age 69.88 ± 13.73 years) who had...