A5054459303- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Retinal Diseases and Treatments
- Photoreceptor and optogenetics research
- Ocular and Laser Science Research
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- melanin and skin pigmentation
- Ocular Disorders and Treatments
- Intraocular Surgery and Lenses
- Infrared Target Detection Methodologies
- Dermatological and Skeletal Disorders
- Autoimmune and Inflammatory Disorders
- Corneal Surgery and Treatments
- Retinal Imaging and Analysis
- Cardiac Imaging and Diagnostics
- Circadian rhythm and melatonin
- Photochromic and Fluorescence Chemistry
- Retinal and Optic Conditions
- Blood Pressure and Hypertension Studies
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
Universitätsklinikum Erlangen
2014-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2023
Bayer (Germany)
2021
Zimmer Biomet (United States)
2003
Interpretation of dobutamine stress echocardiography (DSE) is subjective and strongly dependent on the skills reader. Strain-rate imaging (SRI) by tissue Doppler may objectively analyze regional myocardial function. This study investigated SRI markers stress-induced ischemia analyzed their applicability in a clinical setting.DSE was performed 44 patients with known or suspected coronary artery disease. Simultaneous perfusion scintigraphy served as "gold standard" to define ischemia. All...
Purpose: Stargardt disease (STGD1) is an autosomal recessive retinopathy, caused by mutations in the retina-specific ATP-binding cassette transporter (ABCA4) gene. To establish mutational spectrum and to assess effects of selected deep intronic common genetic variants on disease, we performed a comprehensive sequence analysis large cohort German STGD1 patients. Methods: DNA samples 335 patients were analyzed for ABCA4 its 50 coding exons adjacent sequences resequencing array technology or...
Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim this study was to measure alterations trace levels aqueous humor patients with non-exsudative (dry) AMD. For pilot study, samples were collected from undergoing cataract surgery. 12 dry AMD (age 77.9±6.62, female 8, male 4) and 11 without 66.6±16.7, 7, included. Aqueous cadmium, cobalt, copper, iron, manganese, selenium, zinc measured by use...
Optic neuritis leads to degeneration of retinal ganglion cells whose axons form the optic nerve. The standard treatment is a methylprednisolone pulse therapy. This slightly shortens time recovery but does not prevent neurodegeneration and persistent visual impairment. In phase II trial performed in preparation this study, we have shown that erythropoietin protects global nerve fibre layer thickness (RNFLT-G) acute neuritis; however, preparatory was powered show effects on function. Treatment...
Increased expression of glial fibrillary acidic protein (GFAP) is a characteristic gliotic activation (Müller cells and astrocytes) in the retina. This study assessed vitreous body GFAP levels various forms retinal pathology.This prospective included 82 patients who underwent vitrectomy (46 detachments (RDs), 13 macular hole (MHs), 15 epiretinal glioses (EGs), 8 organ donors). An established enzyme-linked immunosorbent assay (ELISA, SMI26) was used for quantification GFAP.The highest...
To identify patterns of functional defects in perifoveal photoreceptor-directed temporal contrast sensitivities (tCSs) patients with inherited retinal diseases. We retrospectively studied RP1L1-associated occult macular dystrophy (OMD), Stargardt disease (STGD), and RP. Photoreceptor-directed tCS directed at L-, M-, S-cones rods different frequencies were measured using a four-primary LED-stimulator an annular test field (2° inner diameter 12° outer diameter). Mean (MDs) calculated by...
Abstract Inherited retinal dystrophies (IRDs) and inherited optic neuropathies (IONs) are characterized by distinct genetic causes molecular mechanisms that can lead to varying degrees of visual impairment. The discovery pathogenic variants in numerous genes associated with these conditions has deepened our understanding the pathways influence both vision disease manifestation may ultimately novel therapeutic approaches. Over past 18 years, DNA diagnostics unit been performing testing on...
We evaluated a technique for measuring temporal contrast sensitivities to sine-wave modulation driven by S-cones and rods in the perifovea using triple silent substitution. Isolating stimuli were created an eight-channel, four-primary LED stimulator that has been validated before. Sensitivities measured at 10 different frequencies between 1 28 Hz three normal observers 14 retinal illuminances 0.07 587 photopic troland (phot Td) over same range one S-cone monochromat. The was further...
We established a protocol using well-established LED stimulator to measure temporal contrast sensitivities driven by sine-wave modulation of L- and M-cones in the perifovea triple silent substitution. The stimulus was presented an annular field (2° inner diameter, 13° outer diameter). validated this technique studying sensitivity three color normal observers at 10 different frequencies (between 1 28 Hz) over large range retinal illuminances 0.07 587 phot Td), spanning complete mesopic range....
Purpose To psychophysically determine macular pigment optical density (MPOD) employing the heterochromatic modulation photometry (HMP) paradigm by estimating 460 nm absorption at central and peripheral retinal locations. Methods For HMP measurements, two lights (B: R: 660 nm) were presented in a test field modulated counterphase medium or high frequencies. The contrasts of varied tandem to flicker detection thresholds. Detection thresholds measured for different R:B ratios. ratio with...
The silent substitution paradigm offers possibilities to investigate and compare the temporal properties of mechanisms driven by single photoreceptor types, including critical flicker frequency (CFF), in which state adaptation can be kept as invariant. We have (1) measured CFFs using triple substitutions isolate L-, M-, S-cone well rod-driven pathways under identical mean luminances chromaticities; (2) repeated CFF measurements at different order validate Ferry-Porter law (stating that...
Abstract Chloroquine and hydroxychloroquine, while effective in rheumatology, pose risks of retinal toxicity, necessitating regular screening to prevent visual disability. The gold standard for includes imaging automated perimetry, with multifocal electroretinography (mfERG) being a recognized but less accessible method. This study explores the efficacy Artificial Intelligence (AI) algorithms detecting damage patients undergoing (hydroxy-)chloroquine therapy. We analyze mfERG data, comparing...
Purpose: The purpose of this study was to compare L-, M-, S-cone-, and rod-driven temporal contrast sensitivities (tCS) in patients with RP1L1-associated autosomal-dominant occult macular dystrophy (OMD), investigate how photoreceptor degeneration determines which post-receptoral channels dominate perception. Methods: Photoreceptor isolating stimuli were created the silent substitution technique. Photoreceptor-selective tCS deviations (D L-cone/M-cone/S-cone/Rod) obtained as a function...
Background: Low vision in children can be accompanied by pallor of the optic disc with little or no characteristic morphologic changes retina. A variety diseases underlying cause, including hereditary atrophy, Leber's congenital amaurosis (LCA), achromatopsia, and calcium channel, voltage-dependent, L-type, alpha-1F subunit gene (CACNA1F)-associated retinopathy (most widely known as incomplete stationary night blindness: iCSNB). Differentiation at early age is desirable due to large...
Purpose: Inherited retinal diseases affect the L-, M-, S-cones and rods in distinct ways, which calls for new methods that enable quantification of photoreceptor-specific functions. We tested feasibility using silent substitution paradigm to estimate photoreceptor-driven temporal contrast sensitivity (tCS) functions patients with retinitis pigmentosa. Methods: The is based on lights different spectral composition; this offers considerable advantage over other stimulation techniques. used a...
To examine the influence of cold pressor test (CPT) on steady-state pattern electroretinograms (PERG) in healthy subjects and glaucoma patients.Steady-state PERGs to 7.8 Hz reversal stimuli were recorded 63 subjects. Fifteen control subjects, 14 patients with ocular hypertension (OHT), 34 open-angle (20 normotensive [NTG] high tension [HTG]) examined. Steady-state PERG amplitudes latencies analyzed at baseline, during stimulus using a modified CPT, subsequent recovery phase. Blood pressure...
<i>Background:</i> In this report we present a patient with unilateral membranous cataract and describe the histological biochemical findings accompanying rare condition. <i>Methods:</i> The underwent an uneventful extraction. Aqueous humor (20 µl) was aspirated from anterior chamber intraoperatively processed for fibroblast growth factor (FGF) epidermal (EGF) using immunoassay method (ELISA). lens material subjected to examination. <i>Results:</i> had...
Inherited retinal diseases with cone dysfunction can be accompanied by severe visual loss and a marked of color vision despite relatively normal fundus appearance. Autosomal dominant occult macular dystrophy (RP1L1 gene) X‑chromosomal retinitis pigmentosa (RPGR gene, including heterozygous female carriers) are important examples. New examination techniques enable quantification the extent disturbances.After thorough clinical examination, discrimination function were quantified. The Cambridge...