A5043778382- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Retinal Diseases and Treatments
- Connexins and lens biology
- Testicular diseases and treatments
- Multisensory perception and integration
- Muscle Physiology and Disorders
- Sperm and Testicular Function
- CCD and CMOS Imaging Sensors
- Impact of Light on Environment and Health
- Neurobiology and Insect Physiology Research
- Immunotherapy and Immune Responses
- Fault Detection and Control Systems
- Vestibular and auditory disorders
Ludwig-Maximilians-Universität München
2022
Universitätsklinikum Erlangen
2015-2019
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2017
The University of Melbourne
2009-2016
Australian College of Optometry
2010-2016
National Eye Institute
2003
The global or gross response index of visual performance measured from the eye does not necessarily translate to responses brain. A better understanding this relationship would facilitate monitoring disease models that affect pathway. We consider whether rod- and cone-retino-cortical-pathways are equally affected by acute IOP elevation.Acute, stepwise elevation (10, 30, 40, 50, 60, 70 mm Hg) was induced in anesthetized dark- (N = 8) light-adapted pigmented rats 6). Electroretinogram (ERG)...
An overview of electroretinogram response components to incremental and decremental steps in L- M-cone excitation was obtained human observers, while varying the spatial properties stimulus. Responses stimuli opposite polarity resembled each other, particularly within central 35° retina. All amplitudes grew as stimulus size increased; however, earlier later On- Off-responses showed differing degrees dependency on size. Thus, they may reflect different proportions responses originating...
When combined with the electroretinogram (ERG), heterochromatic flicker photometry procedure allows an objective in vivo assessment of postreceptoral activity. Responses evoked at intermediate (approximately 12 Hz) and high (>30 temporal frequencies reflect red-green cone opponent (possibly parvocellular) luminance magnocellular) responses, respectively. Previously, we found that cone-isolating stimuli elicited ERG responses similar amplitudes phases for different spatial arrangements...
The electroretinogram (ERG) and visual evoked potential (VEP) are commonly used to assess the integrity of pathway. ERG measures electrical responses retina light stimulation, while VEP corresponding functional pathways from primary cortex following same event. waveform can be broken down into components that reflect different retinal neuronal glial cell classes. early represent optic nerve higher cortical centers. These recordings conducted in isolation or together, depending on...
Visual information is processed in parallel pathways the visual system. Parallel processing begins at synapse between photoreceptors and their postreceptoral neurons human retina. The integrity of this first neural connection vital for normal downstream. Of numerous elements necessary proper functioning synaptic contact, dystrophin proteins eye play an important role. Deficiency muscle causes Duchenne muscular dystrophy (DMD), X-linked disease that affects function leads to decreased life...
The dystrophin mouse mutant mdx3Cv exhibits scotopic electroretinograpic (ERG) abnormalities, which resemble clinical changes observed in Duchenne muscular dystrophy (DMD) patients. In the present study, ERGs obtained from and their wild-type littermates under scotopic, mesopic, photopic conditions were analyzed to provide further insight on affected retinal pathways, compare them with human data.Electroretinograms of (n = 9) age-matched C57BL/6J mice 10) included full-field flash (for outer...
The mouse is commonly used for studying retinal processing, primarily because it amenable to genetic manipulation. To accurately study photoreceptor driven signals in the healthy and diseased retina, of great importance isolate responses single types. This not easily achieved mice strong overlap rod M-cone absorption spectra (i.e., maxima at 498 508 nm, respectively). With a newly developed model (Opn1lw(LIAIS)) expressing variant human L-cone pigment (561 nm) instead M-opsin, are...
The clearer divergence in spectral sensitivity between native rod and human L-cone (L*-cone) opsins the transgenic Opn1lwLIAIS mouse (LIAIS) allows normal visual processes mediated by these photoreceptor subtypes to be isolated effectively using silent substitution technique. objective of this study was further characterize influence mean luminance temporal frequency on functional properties signals originating each separately independently adaptation state LIAIS mice.Electroretinographic...
To date, most studies involving in vivo electroretinography mice are performed on steady state adapted animals. In this study, we focused the dynamics of adaptation to high and low light levels mouse retina. Two flash electroretinogram (ERG) protocols one flicker ERG protocol were employed. two protocols, animals either 25 or 40 cd/m2 white ERGs recorded for up 15 min adaptation. Afterwards, 45 dark Amplitudes increased during adaptation, while implicit times different wave components...
L and M cones send their signals to the cortex using two chromatic (parvocellular blue-yellow koniocellular) one luminance (magnocellular) pathways. These pathways contain ON OFF subpathways that respond excitation increments decrements respectively. Here, we report on visually evoked potentials (VEP) recordings reflect L- M-cone driven increment (LI MI) decrement (LD MD) activity. VEP were performed 12 trichromats four dichromats (two protanopes deuteranopes). We found responses LI strongly...
Integrated motor behaviors involving ocular motion-associated movements of the head, neck, pinna, and parts face are commonly seen in animals orienting to a visual target. A number coordinated have also been observed humans making rapid gaze shifts horizontal extremes, which may be vestiges these. Since such integrated mechanisms point nonpathological coactivation several anatomically separate cranial circuits humans, it is important see how different pairs integrative with common trigger...
The cellular origins of slow ERG changes during light adaptation following a dark-adapted state are still unclear. To study adaptation, six healthy, normal trichromats were for 30 min prior to full-field recordings sinusoidal stimuli that isolate responses the L- or M-cones stimulate luminance and chromatic mechanisms at 12 36 Hz. Recordings performed 16 with 2-min intervals after onset constant background. Generally, sine-wave-like, first harmonic (fundamental) component dominated Fourier...
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
The electroretinogram (ERG) and visual evoked potential (VEP) are commonly used to assess the integrity of pathway. ERG measures electrical responses retina light stimulation, while VEP corresponding functional pathways from primary cortex following same event. waveform can be broken down into components that reflect different retinal neuronal glial cell classes. early represent optic nerve higher cortical centers. These recordings conducted in isolation or together, depending on...