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Alexander Zähringer

ORCID: 0009-0006-1079-8214
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A5097984181
Research Areas
  • Cancer Immunotherapy and Biomarkers
  • Cancer Mechanisms and Therapy
  • Colorectal Cancer Treatments and Studies
  • Pancreatic and Hepatic Oncology Research
  • Pancreatitis Pathology and Treatment
  • Chronic Myeloid Leukemia Treatments
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Glioma Diagnosis and Treatment
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Acute Myeloid Leukemia Research
  • CAR-T cell therapy research

University of Freiburg
 2024

University Medical Center Freiburg
 2024

 Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
OPENALEX - Publications 
Janaki Manoja Vinnakota Francesca Biavasco Marius Schwabenland Chintan Chhatbar Rachael C. Adams and 59 more Daniel Erny Sandra Duquesne Nadia El Khawanky Dominik Schmidt Viktor Fetsch Alexander Zähringer Henrike Salié Dimitrios Athanassopoulos Lukas M. Braun Nora R. Javorniczky Jenny N. H. G. Ho Katrin Kierdorf Reinhard Marks Ralph Wäsch Federico Simonetta Geoffroy Andrieux Dietmar Pfeifer Gianni Monaco Christian M. Capitini Terry J. Fry Thomas Blank Bruce R. Blazar Eva Wagner Matthias Theobald Clemens Sommer Matthias Stelljes Christian Reicherts Astrid Jeibmann Jens Schittenhelm Camelia‐Maria Monoranu Andreas Rosenwald K. Martin Kortüm Leo Rasche Hermann Einsele Philipp T. Meyer Joachim Brumberg Simon Völkl Andréas Mackensen Roland Coras Michael von Bergwelt‐Baildon Nathalie L. Albert Laura M. Bartos Matthias Brendel Adrien Holzgreve Matthias Mack Melanie Boerries Crystal L. Mackall Justus Duyster Philipp Henneke Josef Priller Natalie Köhler Felix Strübing Bertram Bengsch Marco Ruella Marion Subklewe Louisa von Baumgarten Saar Gill Marco Prinz Robert Zeiser

10.1038/s43018-024-00764-7 article EN Nature Cancer 2024-05-13
 Anti–PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation
OPENALEX - Publications 
Janaki Manoja Vinnakota Rachael C. Adams Dimitrios Athanassopoulos Dominik Schmidt Francesca Biavasco and 28 more Alexander Zähringer Daniel Erny Marius Schwabenland Marlene Langenbach Valentin Wenger Henrike Salié James Cook Omar Mossad Geoffroy Andrieux Rick Dersch Sebastian Rauer Sandra Duquesne Gianni Monaco Phillipp Wolf Thomas Blank Philipp Häne Melanie Greter Burkhard Becher Philipp Henneke Dietmar Pfeifer Bruce R. Blazar Justus Duyster Melanie Boerries Natalie Köhler Chintan Chhatbar Bertram Bengsch Marco Prinz Robert Zeiser

Cancer treatment with anti-PD-1 immunotherapy can cause central nervous system immune-related adverse events (CNS-irAEs). The role of microglia in immunotherapy-induced CNS-irAEs is unclear. We found that mice caused morphological signs activation and major histocompatibility complex (MHC) class II up-regulation on microglia. Functionally, induced neurocognitive deficits mice, independent T cells, B natural killer cells. Instead, we mediated these CNS-irAEs. Single-cell RNA sequencing...

10.1126/scitranslmed.adj9672 article EN Science Translational Medicine 2024-06-12
 AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling
OPENALEX - Publications 
Alexander Zähringer Ines Morgado Daniel Erny Florian Ingelfinger Jana Gawron and 28 more Subhendra Chatterjee Valentin Wenger Dominik Schmidt Lennard Frederik Schwöbel Rachael C. Adams Marlene Langenbach Alina M. Hartmann Natascha Osswald Julian Wolf Günther Schlunck Priscilla S. Briquez Kathleen Grueter Dietrich Alexander Ruess Ian J. Frew Ann‐Cathrin Burk Verena Holzmüller Bodo Grimbacher David Michonneau Geoffroy Andrieux Gèrard Socié Julia Kolter Melanie Börries Marie Follo Franziska Blaeschke Lisa Sevenich Marco Prinz Robert Zeiser Janaki Manoja Vinnakota

10.1182/bloodadvances.2024015000 article EN cc-by-nc-nd Blood Advances 2025-03-31
 Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment
OPENALEX - Publications 
Dominik Schmidt Cornelia Endres Rouven Hoefflin Geoffroy Andrieux Melissa Zwick and 24 more Nikolaos Karantzelis Hans F. Staehle Janaki Manoja Vinnakota Sandra Duquesne Miriam Mozaffari Jovein Dietmar Pfeifer Heiko Becker Bruce R. Blazar Alexander Zähringer Justus Duyster Tilman Brummer Melanie Boerries Julian Baumeister Khalid Shoumariyeh Juan Li Anthony R. Green Florian H. Heidel Itay Tirosh Heike L. Pahl Nils B. Leimkühler Natalie Köhler Marcelo A. S. Toledo Steffen Koschmieder Robert Zeiser

Abstract Increasing evidence supports the interplay between oncogenic mutations and immune escape mechanisms. Strategies to counteract mediated by signaling could provide improved therapeutic options for patients with various malignancies. As mutant calreticulin (CALR) is a common driver of myeloproliferative neoplasms (MPN), we analyzed impact CALRdel52 on bone marrow (BM) microenvironment in MPN. Single-cell RNA-sequencing revealed that led expansion TGF-β1-producing erythroid progenitor...

10.1158/0008-5472.can-23-3553 article EN Cancer Research 2024-06-17
 Data from Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
OPENALEX - Publications 
Dominik Schmidt Cornelia Endres Rouven Hoefflin Geoffroy Andrieux Melissa Zwick and 24 more Nikolaos Karantzelis Hans F. Staehle Janaki Manoja Vinnakota Sandra Duquesne Miriam Mozaffari Jovein Dietmar Pfeifer Heiko Becker Bruce R. Blazar Alexander Zähringer Justus Duyster Tilman Brummer Melanie Boerries Julian Baumeister Khalid Shoumariyeh Juan Li Anthony R. Green Florian H. Heidel Itay Tirosh Heike L. Pahl Nils B. Leimkühler Natalie Köhler Marcelo A. S. Toledo Steffen Koschmieder Robert Zeiser

<div>Abstract<p>Increasing evidence supports the interplay between oncogenic mutations and immune escape mechanisms. Strategies to counteract mediated by signaling could provide improved therapeutic options for patients with various malignancies. As mutant calreticulin (CALR) is a common driver of myeloproliferative neoplasms (MPN), we analyzed impact CALR<sup>del52</sup> on bone marrow (BM) microenvironment in MPN. Single-cell RNA sequencing revealed that led...

10.1158/0008-5472.c.7451256 preprint EN 2024-09-16
 Supplementary Data from Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
OPENALEX - Publications 
Dominik Schmidt Cornelia Endres Rouven Hoefflin Geoffroy Andrieux Melissa Zwick and 24 more Nikolaos Karantzelis Hans F. Staehle Janaki Manoja Vinnakota Sandra Duquesne Miriam Mozaffari Jovein Dietmar Pfeifer Heiko Becker Bruce R. Blazar Alexander Zähringer Justus Duyster Tilman Brummer Melanie Boerries Julian Baumeister Khalid Shoumariyeh Juan Li Anthony R. Green Florian H. Heidel Itay Tirosh Heike L. Pahl Nils B. Leimkühler Natalie Köhler Marcelo A. S. Toledo Steffen Koschmieder Robert Zeiser

<p>Supplementary data</p>

10.1158/0008-5472.27024108.v1 preprint EN 2024-09-16
 Data from Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
OPENALEX - Publications 
Dominik Schmidt Cornelia Endres Rouven Hoefflin Geoffroy Andrieux Melissa Zwick and 24 more Nikolaos Karantzelis Hans F. Staehle Janaki Manoja Vinnakota Sandra Duquesne Miriam Mozaffari Jovein Dietmar Pfeifer Heiko Becker Bruce R. Blazar Alexander Zähringer Justus Duyster Tilman Brummer Melanie Boerries Julian Baumeister Khalid Shoumariyeh Juan Li Anthony R. Green Florian H. Heidel Itay Tirosh Heike L. Pahl Nils B. Leimkühler Natalie Köhler Marcelo A. S. Toledo Steffen Koschmieder Robert Zeiser

<div>Abstract<p>Increasing evidence supports the interplay between oncogenic mutations and immune escape mechanisms. Strategies to counteract mediated by signaling could provide improved therapeutic options for patients with various malignancies. As mutant calreticulin (CALR) is a common driver of myeloproliferative neoplasms (MPN), we analyzed impact CALR<sup>del52</sup> on bone marrow (BM) microenvironment in MPN. Single-cell RNA sequencing revealed that led...

10.1158/0008-5472.c.7451256.v1 preprint EN 2024-09-16
 Supplementary Data from Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
OPENALEX - Publications 
Dominik Schmidt Cornelia Endres Rouven Hoefflin Geoffroy Andrieux Melissa Zwick and 24 more Nikolaos Karantzelis Hans F. Staehle Janaki Manoja Vinnakota Sandra Duquesne Miriam Mozaffari Jovein Dietmar Pfeifer Heiko Becker Bruce R. Blazar Alexander Zähringer Justus Duyster Tilman Brummer Melanie Boerries Julian Baumeister Khalid Shoumariyeh Juan Li Anthony R. Green Florian H. Heidel Itay Tirosh Heike L. Pahl Nils B. Leimkühler Natalie Köhler Marcelo A. S. Toledo Steffen Koschmieder Robert Zeiser

<p>Supplementary data</p>

10.1158/0008-5472.27024108 preprint EN 2024-09-16
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