A5101637182- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Hydrocarbon exploration and reservoir analysis
- Intensive Care Unit Cognitive Disorders
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Paleontology and Stratigraphy of Fossils
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Alcohol Consumption and Health Effects
- Cardiac Ischemia and Reperfusion
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- Exercise and Physiological Responses
- Fibroblast Growth Factor Research
- Healthcare and Venom Research
- CRISPR and Genetic Engineering
Southern Medical University
2015-2024
Dongguan People’s Hospital
2016-2024
China University of Geosciences (Beijing)
2023-2024
Zhangzhou Municipal Hospital of Fujian Province
2024
Fujian Medical University
2024
Wenzhou Medical University
2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Cardiff University
2018
University Hospital Llandough
2018
Shijiazhuang Yiling Pharmaceutical (China)
2018
Abstract CRISPR/Cas13a is a powerful genome editing system for RNA knockdown that holds enormous potential cancer treatment by targeting currently undruggable oncogenes or immune checkpoints. However, the precise intratumoral activation of to maximize therapeutic efficiency while guaranteeing biosafety remains daunting challenge. Here, cascade self‐uncloaking nanoassembly (SRC) based on dual‐prodrug comprising SN38 and Cas13a/RNP developed, external encapsulation performed coating with...
Alda‑1, an aldehyde dehydrogenase 2 (ALDH2) agonist, has been demonstrated to reduce injury caused by acute myocardial infarction (MI) and ischemia/reperfusion. The present study aimed investigate whether oral administration of Alda‑1 improved long‑term survival rats with chronic heart failure (CHF) post‑MI. MI model treated daily exhibited increase in 20‑week rate compared untreated rats. treatment decreased the weight/body weight ratio, collagen volume, left ventricular (LV) internal...
Myocardial cell apoptosis mediated by oxidative stress has previously been identified as a key process in ischemic heart disease. Secoisolariciresinol diglucoside (SDG), polyphenolic plant lignan primarily found flaxseed, demonstrated to effectively protect myocardial cells from apoptosis. In the present study, role of Janus kinase 2 (JAK2)/signal transducer and activator transcription 3 (STAT3) was investigated mediating protective effect SDG. Findings study revealed that treatment with...
To assess the effect of tear film instability in dry eye disease (DED) by measuring visual performance and optical quality a simultaneous real-time analysis system. Thirty-seven DED participants 20 normal controls were recruited. A system was developed adding functional acuity (FVA) channel to double-pass Repeated measurements FVA objective scatter index (OSI) performed simultaneously with this under blink suppression condition for s. Patient-reported symptoms evaluated using Ocular Surface...
Abstract The mortality caused by cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) ranks second among female malignant tumour deaths, but their diagnostic therapeutic targets are still limited. N6‐methyladenosine (m6A) is the most common extensive modification in mRNA molecules, its methylation regulators participate regulating occurrence development of many tumours. However, whether m6A RNA can be used as independent prognostic indicators CESC remains unknown. This...
Lung cancer is the leading cause of cancer-associated mortality worldwide, and most lung cancers are classified as non-small cell (NSCLC). MiR-328 influence progression multiple tumors, but role miR-328-5p in NSCLC has not been elucidated. The aim this study was to illuminate oncogenic potential molecular mechanisms lysyl oxidase like 4 (LOXL4) NSCLC.Expression detected by real-time quantitative polymerase chain reaction (qRT-PCR) tumor non-tumor adjacent tissues. After Lentivirus-miR-328-5p...
Heart, liver, and kidney, which are known as the essential organs for metabolism, possess unique ability to regulate proliferation function of body against injury. Silibinin (SB), a natural polyphenolic flavonoid extracted from traditional herb Silybum marianum L., has been used protect hepatocytes. Whether SB can mitochondrial fission in normal cells underlying mechanisms remain unclear. Here, we showed that markedly promoted cell by facilitating G1/S transition via activating...
To the Editor: Mitochondrial function is one of most cutting-edge fields in current research and further study needed to investigate specific signaling mechanisms mitochondrial function. A previous has suggested that exercise increases energy metabolism via regulating dynamics by multiple mechanisms.[1] recent demonstrated electrical stimulation (ES) regulated increase reactive oxygen species (ROS) production.[2] However, whether effects ES on are associated with autophagy potential pathways...
Background: Trastuzumab resistance in HER-2 positive breast cancer cells is closely related to overexpression of both epidermal growth factor receptor (EGFR) and human (HER-2). SHP-1 has been demonstrated downregulate tyrosine kinase activity including EGFR via its phosphatase function, but effect on still unknown. Here, we examined the hypothesis that enhances anticancer efficacy trastuzumab EGFR/HER-2 through combining dual inhibition HER-2. Methods: Trastuzumab-resistant SKBr-3 were...
The spectrum allocated to an end-to-end connection between source and destination nodes varies dynamically with time (denoted as time-varying traffic). For serving traffic in Elastic optical network (EON), the for can be expanded or contracted meet requirement. Moreover, multipath routing algorithms more flexibly utilize resources than single-path dynamic scenario, since it splits a request into multiple small-size connections individually transmitting them through several paths. In this...
The aim of the present study was to investigate effect heart rate (HR) on diagnostic accuracy 256-slice computed tomography angiography (CTA) in detection coronary artery stenosis. Coronary imaging performed using a Philips spiral CT, and receiver operating characteristic (ROC) curve analysis conducted evaluate value CTA HR research subjects within certain range (39-107 bpm). One hundred patients suspected disease underwent examination. cases were divided into three groups: Low (HR <75 bpm),...
The effect of different vasoactive drugs on the pH [intracellular (pH
The expression level and prognosis of Toll-like receptor 2 (TLR2) mRNA in peripheral blood mononuclear cells patients with severe sepsis after applying pulse high-volume hemofiltration (PHVHF) were investigated. Sustained PHVHF treatment was carried out on 40 the basis conventional for up to 72 h. Acute physiology chronic health evaluation (APACHE) Ⅱ scores compared before treatment. CD4+, CD8+ lymphocyte counts ratios detected using FASort 24 48 h Enzyme‑linked immunosorbent assay adopted...
To study the inhibitory effect of 10-gingerol on proliferation hepatocellular carcinoma HepG2 cells and role Src/STAT3 signaling pathway in mediating effect.SYBYL-X2.1 software was used to simulate interaction between Src. treated with at 1, 3, 10 or μol/L for 24 h were assessed cell viability using MTT assay, EdU staining detect calculate number positive cells. The expressions p-Src p-STAT3 detected Western blotting, mRNA target genes STAT3 (cyclin D1 CMCC) qPCR.10-gingerol capable forming...
Cambrian age strata are the critical development and research stratum series of oil gas reserves in Tarim Basin, which contains rich resources. The restoration carbonate platform conversion main control factors has significant implication for distribution ultra-deep dolomite reservoirs. Based on a large number drilling outcrop profile data, micro geomorphic characteristics platforms different periods period reconstructed western area, basin filling structure, paleoclimate, sea level change,...
The genesis of deep-to-ultra-deep dolomite reservoirs in the Tarim Basin is crucial for exploration and development. Cambrian subsalt are widely distributed, marking significant prospects ultra-deep reservoir exploration. Based on big data methodologies, this study collects analyzes porosity permeability carbonate western Basin, specifically targeting deep-oil gas-reservoir research. Through an examination sedimentary evolution distribution carbonate–evaporite sequences, considering facies,...
Abstract Smoking is one of the major contributors to airway injuries. N‐acetylcysteine (NAC) has been proposed as a treatment or preventive measure for such However, exact nature smoking‐induced injury and protective mechanism NAC are not yet fully understood. Here, patient tissue‐derived organoids modeling injury, therapeutic investigation, studies developed. Airway consist mainly ciliated cells, together with basal goblet myofibroblast‐like cells. The display apical‐out basal‐in polarity...
Background: Esophageal squamous cell carcinoma (ESCC) is the most important pathological type of esophageal cancer with high incidence and limited efficient therapies in China worldwide. Understanding ESCC genomic features advantageous for exploring clinical therapeutic strategies. Methods: Deep sequencing targeting 450 genes was performed on FFPE matched blood samples collected from 90 Chinese patients(pts) a median age 60 years old. Genomic alterations (GAs) including single nucleotide...
Abstract Background EGFR-TKIs have shown remarkable effect in non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. Nevertheless, several mechanisms including activation of PI3K/AKT/mTOR pathway been proved to generate acquired assistance EGFR-TKIs. In this study, we investigated the genomic characteristics PI3K NSCLC resistance and whether both targeting mTOR could reverse resistance. Methods A total 605 cases who received prior TKI treatment were reviewed, which 328...