A5074543270- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Inflammasome and immune disorders
- Gut microbiota and health
- Plant biochemistry and biosynthesis
- Head and Neck Cancer Studies
- Heavy Metals in Plants
- Alcohol Consumption and Health Effects
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Studies
- Mitochondrial Function and Pathology
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Dialysis and Renal Disease Management
- Metabolism and Genetic Disorders
- Oral Health Pathology and Treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- Bladder and Urothelial Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alkaloids: synthesis and pharmacology
- Ferroptosis and cancer prognosis
Southern Medical University
2020-2025
Shanghai Ocean University
2024
Zhujiang Hospital
2021-2024
Dongguan People’s Hospital
2024
Ollscoil na Gaillimhe – University of Galway
2023
Hebei Medical University
2023
TCM-Intigrated Cancer Center of Southern Medical University
2020-2022
Peking University
2022
Guangzhou University of Chinese Medicine
2017-2019
Shaoguan University
2019
Abstract Background The prevalence of hyperuricaemia (HUA), a metabolic disorder characterized by elevated levels uric acid, is on the rise and frequently associated with renal injury. Gut microbiota gut-derived uremic toxins are critical mediators in gut-kidney axis that can cause damage to kidney function. dysbiosis has been implicated various diseases. However, role underlying mechanism gut HUA-induced injury remain unknown. Results A HUA rat model was first established knocking out...
Inflammation and apoptosis of vascular endothelial cells play a key role in the occurrence development atherosclerosis (AS), AMPK/mTOR/Nrf2 signaling pathway plays an important alleviating symptoms AS. Geniposide combined with notoginsenoside R1 (GN combination) is patented supplement for prevention treatment It has been proven to improve blood lipid levels inhibit formation AS plaques; however, it still unclear whether GN combination can inflammation by regulating its downstream signals....
Abstract Context Qi‐dan‐dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. Objective This study reveals mechanism by which QDD ameliorates DKD. Materials and Methods The compounds in were identified high‐performance liquid chromatography quadrupole‐time‐of‐flight tandem mass spectrometry (HPLC‐Q‐TOF‐MS). Key targets signaling pathways screened through bioinformatics. Nondiabetic Lepr db/m mice as control group,...
Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.The study investigated whether azithromycin (AZT) could promote high-fat diet (HFD)-induced Moreover, effect of citrus reticulata pericarpium (CRP) extract on via regulation microbiome exposed antibodies early life were...
Cervical cancer is the fourth leading type and second most common gynecological malignancy among women worldwide. Silibinin (SB), a chief bioactive natural polyphenolic flavonoid of Silybum marianum L., has been used clinically for its hepatocyte protective effects. It also anticancer effects via induction apoptosis cell cycle arrest. However, SB on cervical cells through mitochondrial fission have not studied. Here, we showed that markedly suppressed proliferation by inducing G2/M arrest...
Teashirt zinc finger homeobox 3 (TSHZ3) is a transcription factor implicated in the progression of certain cancers. However, its expression and function lung adenocarcinoma (LUAD) remain unclear. Therefore, we aimed to investigate TSHZ3 assess prognostic significance LUAD patients. First, explored data predicted cancer through bioinformatics analysis. We then validated functions using cellular animal experiments. Our results indicated that was significantly lower compared normal tissues....
<title>Abstract</title> Background Cardiovascular disease (CVD) ranks among the top causes of mortality worldwide, particularly impacting US. The Blood Urea Nitrogen-to-Serum Albumin Ratio (BAR) has recently been identified as a promising biomarker that integrates indicators both renal and nutritional health. However, association between BAR CVD not thoroughly explored. Methods This study utilized cross-sectional data from individuals aged ≥ 20 years who participated in NHANES 2011–2018. To...
Ilex pubescens Hook et Arn mainly contains triterpenoids that possess antithrombotic, anti-inflammatory and analgesic effects. Quantitative qualitative analyses of the in I. can be useful for determining authenticity quality raw materials guiding its clinical preparation.To establish a method rapid comprehensive analysis using ultra-high-performance liquid chromatography coupled to electrospray ionisation quadrupole time-of-flight-mass spectrometry (UPLC-ESI-QTOF-MS), which will also applied...
Abstract Background The present study aimed to investigate oral cancer awareness and its related knowledge among residents in Beijing. Methods A questionnaire survey was conducted Beijing concerning their of cancer, prevention treatment. Results total 3055 questionnaires were completed, 45.8% by males 54.2% females. ages the respondents ranged from 15 93 years; 12.4% smokers, 1.1% chewed betel nuts, 82.5% brushed teeth at least twice a day. Lung heard most respondents, followed gastric liver...
Zhenwu Decoction (ZWD) is a traditional Chinese medicine (TCM) formula which has wide scope of indications related to Yang deficiency and dampness retention in TCM syndrome. Cardiac hypertrophy can induce similar symptoms signs the clinical features ZWD increase left ventricular ejection fraction, reduce cardiac patients with chronic heart failure. However, its underlying pharmacological mechanism remains unclear.The study aimed confirm protective effects on explore mechanisms.The potential...
Background: Intestinal microbial colonization in early life plays a crucial role immune development and mucosal homeostasis later years. Antibiotic exposure increases the risk of inflammatory bowel disease (IBD). Ginger acts like prebiotic has been used traditional Chinese medicine for colitis. We investigated protective effect ginger against dextran sulfate sodium (DSS)-induced colitis mice exposed to antibiotic their Methods: A weaned mouse model azithromycin (AZT) 2 weeks was mimic...
Lung cancer is the leading cause of cancer-associated mortality worldwide, and most lung cancers are classified as non-small cell (NSCLC). MiR-328 influence progression multiple tumors, but role miR-328-5p in NSCLC has not been elucidated. The aim this study was to illuminate oncogenic potential molecular mechanisms lysyl oxidase like 4 (LOXL4) NSCLC.Expression detected by real-time quantitative polymerase chain reaction (qRT-PCR) tumor non-tumor adjacent tissues. After Lentivirus-miR-328-5p...
Introduction Brain metastasis is the terminal event of breast cancer with poor prognoses. Therefore, this article aimed to provide an updated summary on development, hotspots, and research trends brain from based bibliometric analysis. Method Publications retrieved Web Science Core Collection. CiteSpace, VOSviewer, other online analysis platforms were used analyze visualize result. Result In totality, 693 researchers 3,623 institutions across 74 counties regions published a total 2,790...
Heart, liver, and kidney, which are known as the essential organs for metabolism, possess unique ability to regulate proliferation function of body against injury. Silibinin (SB), a natural polyphenolic flavonoid extracted from traditional herb Silybum marianum L., has been used protect hepatocytes. Whether SB can mitochondrial fission in normal cells underlying mechanisms remain unclear. Here, we showed that markedly promoted cell by facilitating G1/S transition via activating...
Variability in volume delineation is a possible error source brachytherapy. This study assessed the interobserver variations clinical target (CTV) postoperative adjuvant 125I seed implant brachytherapy after parotid gland cancer surgical resection and evaluated image fusion technique for delineation.Five radiation oncologists delineated gross tumor (GTV) CTV 20 patients using conventional methods. The consistency was determined on basis of differences between oncologists. Kendall's W-test,...
To evaluate the protective effect of Cuscuta chinensis Lam. polysaccharides (PCCL) on 5-fluorouracil-(5-FU)-induced intestinal mucositis (IM) in mice.PCCL was orally administered at a dose 20 mg·kg-1 for 7 days and its 5-FU-induced IM (5-FU, 50 5 days) evaluated by monitoring changes body weight, degree diarrhea, levels tissue inflammatory factors (tumor necrosis factor α, interleukin 6, 1β levels), apoptosis rates, expression caspase-3, Bax Bcl-2.The severity mucosal injury (as reflected...