A5090250837- Chronic Kidney Disease and Diabetes
- Cancer-related gene regulation
- Cardiac Imaging and Diagnostics
- Intraocular Surgery and Lenses
- Acute Kidney Injury Research
- RNA modifications and cancer
- Traumatic Ocular and Foreign Body Injuries
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Retinal and Macular Surgery
- Ferroptosis and cancer prognosis
- Structural Response to Dynamic Loads
- High-Velocity Impact and Material Behavior
- Circular RNAs in diseases
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Ocular Oncology and Treatments
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Advanced Glycation End Products research
- Ophthalmology and Visual Impairment Studies
- Image Processing Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
Huazhong University of Science and Technology
2023-2024
Central Hospital of Wuhan
2023-2024
Northwest Institute of Nuclear Technology
2010-2024
Central South University
2015-2024
Xiangya Hospital Central South University
2019-2024
Kangda College of Nanjing Medical University
2019-2023
Yangzhou University
2009-2023
Nanjing Medical University
2019-2023
Harbin University of Science and Technology
2023
Jiangsu Vocational College of Medicine
2023
The promise of single-objective light-sheet microscopy is to combine the convenience standard microscopes with speed, coverage, resolution and gentleness microscopes. We present DaXi, a microscope design based on oblique plane illumination that achieves: (1) wider field view high-resolution imaging via custom remote focusing objective; (2) fast volumetric over larger volumes without compromising image quality or necessitating tiled acquisition; (3) fuller coverage for large samples...
Ocular trauma is a major cause of visual loss, but little known about its epidemiology and clinical characteristics in China. The aim this study was to determine the prevalence ocular assess prognostic factors Changsha, Hunan, located South-Central China.A retrospective case series (ICD codes: S05) patients performed at Second Xiangya Hospital, Central South University, from 1 January 2010 31 December 2014. Demographic information, injury causes, types initial final acuity (VA) were recorded...
Abstract Iodinated contrast media serves as a direct causative factor of acute kidney injury (AKI) and is involved in the progression cellular dysfunction apoptosis. Emerging evidence indicates that NLRP3 inflammasome triggers inflammation, apoptosis tissue during AKI. Nevertheless, underlying renoprotection mechanism against contrast-induced AKI (CI-AKI) was still uncertain. This study investigated role CI-AKI both vitro vivo . In HK-2 cells unilateral nephrectomy model, member ASC were...
Abstract Systemic lupus erythematosus (SLE) is a common but severe autoimmune systemic inflammatory disease. Lupus nephritis (LN) serious complication of SLE,affecting up to 70% SLE patients. Circulating microRNAs (miRNA) are emerging as biomarkers for pathological conditions and play significant roles in intercellular communication. In present research, serum samples from healthy control, early late stage LN patients were used analyze the expression profile miRNAs by microarray. Subsequent...
ABSTRACT In the Arabidopsis stomatal lineage, cells transit through several distinct precursor identities, each characterized by unique cell division behaviors. Flexibility in duration of these phases enables plants to alter leaf size and density response environmental conditions; however, transitions between must be complete unidirectional produce functional correctly patterned stomata. Among direct transcriptional targets initiating factor SPEECHLESS, a pair genes, SOL1 SOL2, are required...
A protocol of visible-light-promoted C2 selective arylation quinoline and pyridine N-oxides, with diaryliodonium tetrafluoroborate as an reagent, using eosin Y a photocatalyst for the construction N-heterobiaryls was presented. This methodology provided efficient way synthesis 2-aryl-substituted N-oxides. strategy has following advantages: specific regioselectivity, simple operation, good functional group tolerance, high to moderate yields under mild conditions.
Introduction Uveal melanoma (UVM) is the most invasive intraocular malignancy in adults with a poor prognosis. Growing evidence revealed that immune-related gene related to tumorigenesis and This study aimed construct an prognostic signature for UVM clarify molecular immune classification. Methods Based on The Cancer Genome Atlas (TCGA) database, single-sample set enrichment (ssGSEA) hierarchical clustering analysis were performed identify infiltration pattern of classify patients into two...
Tetramethylpyrazine (TMP), a compound known for its natural health benefits, has garnered significant attention. However, current detection methods TMP are overly expensive and cost-timing. In this study, we developed...
Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes podocyte injury in chronic kidney disease (CKD) by weighted gene correlation network analysis (WGCNA), explore related functions.GSE66107, GSE93798, GSE30528, GSE32591 expression data including models or glomeruli CKD patients were downloaded from the GEO database. R was used for analysis. Differentially expressed (DEGs) (FDR< 0.05 |Fold Change|≥1.5)...
Abstract Oxidative stress has been associated with the etipathogenesis of Diabetic retinopathy (DR). Studies have shown that DJ-1 plays an important role in regulating reactive oxygen species (ROS) production and resistance to oxidative stress-induced apoptosis. This study aimed investigate whether upregulates prevents damage retinal capillary pericytes by increasing antioxidant capacity through Nuclear factor erythroid 2-related 2 (Nrf2) signaling pathway. Nrf2 is a redox-sensitive...
Purpose: Aging alters the function of lacrimal gland and disrupts balance microenvironment on ocular surface, eventually leading to aqueous-tear-deficient dry eye. Mitophagy has been reported play an important role in aging, but underlying mechanism remains unclear. Methods: The young (6 weeks) middle-aged (12 months) male C57BL/6J mice were used this study, mitophagy agonist rapamycin inhibitor Mdivi-1 vivo experiments. Hematoxylin eosin, Masson, Oil Red O, reactive oxygen species (ROS)...
N6-methyladenosine (m6A) is the most abundant modification known in mRNAs. It participates a variety of physiological and pathological processes, such as metabolism, inflammation, apoptosis. To explore mechanism m6A cisplatin-induced acute kidney injury (AKI) berberine alleviation mouse. This study investigated methylome kidneys from three mouse groups: C57 mice (controls), those with CI-AKI (injury group, IG), pretreated (treatment TG). Methylated RNA Immunoprecipitation Next Generation...
Abstract Contrast‐induced nephropathy (CIN) is a condition that causes kidney damage in patients receiving angiography with iodine‐based contrast agents. This study investigated the potential protective effects of berberine (BBR) against CIN and its underlying mechanisms. The researchers conducted both vivo vitro experiments to explore BBR's renal effects. In experiments, SD rats were used create model, different groups established. results showed model group exhibited impaired function,...
Abstract In hospitals, contrast‐induced acute kidney injury (CI‐AKI) is a major cause of renal failure. This study evaluates berberine's (BBR) protection and its potential HDAC4 mechanism. CI‐AKI in rats was induced with 10 mL kg −1 ioversol. Rats were divided into five groups: Ctrl, BBR, CI‐AKI, + Tasq. The function determined by measuring serum creatinine blood urea nitrogen. Histopathological changes apoptosis tubular epithelial cells observed HE terminal deoxynucleotidyl transferase...
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy. The aims of the present study were to screen critical miRNA and corresponding target genes that related development ESCC by weighted gene correlation network analysis (WGCNA) investigate functions experimental validation.Datasets mRNA expression data downloaded from GEO. R software was used for preprocessing differential analysis. differentially expressed protein-coding (DEGs) miRNAs (DEMs) selected (FDR <0.05 or...
To investigate the long-term outcomes and complications of scleral-fixated intraocular lens (SFIOL) implantation without conjunctival peritomies sclerotomy in patients with a history ocular trauma inadequate capsular support during primary pars plana vitrectomy or silicone oil removal.Records who underwent SFIOL removal.Sixty-nine eyes 69 were included this study. The median follow-up period was 34 months (range, 6-99 months). average patient age at time surgery 44 years old 4-80 years). At...
Pathologic changes such as renal tubular atrophy and interstitial fibrosis are common in chronic kidney disease (CKD), which turn, leads to loss of function. The aims present study were screen critical genes with tubulointerstitial lesion CKD by weighted gene correlation network analysis (WGCNA). Gene expression data including 169 samples 21 controls downloaded from Expression Omnibus (GEO) database. Totally 294 differentially expressed (DEGs) screened, 180 upregulated 114 downregulated...
We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, roles XPG polymorphisms in combination with H.pylori infection determining risk cancer. In our study, we collected 337 newly diagnosed cases 347 health controls. Three XPG, rs2296147T>C, rs2094258C>T rs873601G>A, were genotyped using Taqman real-time PCR method 7900 HT sequence detector system. H. pylori was by...