A5010877170- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Bone health and treatments
- Pressure Ulcer Prevention and Management
- Erythropoietin and Anemia Treatment
- Bone Metabolism and Diseases
- Diabetic Foot Ulcer Assessment and Management
- Acute Ischemic Stroke Management
- Art Therapy and Mental Health
- Cell death mechanisms and regulation
- Andrographolide Research and Applications
- Posttraumatic Stress Disorder Research
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Heme Oxygenase-1 and Carbon Monoxide
- Vascular Procedures and Complications
- Traumatic Brain Injury Research
- Peripheral Artery Disease Management
- Orthopedic Surgery and Rehabilitation
- Cardiac Ischemia and Reperfusion
First Affiliated Hospital of Zhengzhou University
2013-2024
Zhengzhou University
2014-2015
As a conventional complication of sepsis, acute kidney injury (AKI) is characterized by high incidence and mortality. Effective management methods are still lacking. Quercetin belongs to kind flavonoids that exerts many functions, for example anti-inflammation anti-fibrosis. However, its function in sepsis AKI uncertain. Our study therefore set out assess the quercetin mice model induced lipopolysaccharide (LPS) human proximal tubular cells (HK-2), including potential mechanisms. was loaded...
Damaged lesion remedial is a devastating impediment of diabetes that escorts to noteworthy disease state, predominantly bottom end diseases. Herbal outputs have exposed be effectual in managing skin abrasions. Kirenol recognized encourage angiogenesis, fibroblast propagation, and exposure cytokines development factors concerned wound remedial. The current study executed appraise the curing action kirenol streptozotocin-persusded diabetic rats by macroscopic parameters, histopathological,...
Osteoarthritis (OA) is a prevalent degenerative joint disease with lack of effective therapeutic. Chondrocyte ferroptosis contributes to the progression OA. PUM2 shown exacerbate ischemia-reperfusion-induced neuroinflammation by promoting ferroptosis, but its role in OA remains unexplored. Here, primary mouse chondrocytes were stimulated IL-1β mimic chondrocyte injury vitro. And was upregulated cartilage tissues and IL-1β-induced chondrocytes. Silencing alleviated inflammation ECM...
We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, roles XPG polymorphisms in combination with H.pylori infection determining risk cancer. In our study, we collected 337 newly diagnosed cases 347 health controls. Three XPG, rs2296147T>C, rs2094258C>T rs873601G>A, were genotyped using Taqman real-time PCR method 7900 HT sequence detector system. H. pylori was by...
As the most common primary bone neoplasm, osteosarcoma is highly aggressive and represents a high risk to human health. Biological agents, including tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), are considered promising therapeutic strategies for osteosarcoma. The current issue limiting application of TRAIL gene therapy that normal cells also affected due lack selectivity. present study aimed employ miRNA response elements (MREs) microRNA (miR)-34 miR-122, which...
The influence of albumin towards the metabolism behavior fenoprofen enantiomers and relevant drug-drug interaction was investigated in present study. metabolic compared a phase II incubation system with without bovine serum (BSA). BSA supplement increased binding affinity parameter (Km) (R)-fenoprofen human liver microsomes (HLMs) from 148.3 to 214.4 μM. In contrast, decreased Km (S)-fenoprofen HLMs 218.2 123.5 For maximum reaction velocity (Vmax), addition Vmax 1.3 1.6 nmol/min/mg protein....
Bone marrow mesenchymal stem cells (BMSC) have the ability to multi polarize with multiple tropisms and participate in tissue remodeling. This study assessed effect of titanium dioxide nanotubes different diameters on ossification BMSC HIF-1α expression ossification. Titanium were prepared then following groups set according size pressure; Ti group, NT10 NT30 NT60 group. Analysis cell morphology was done by fluorescence microscope, while adhesion proliferation MTT assay. Moreover, ALP...
Objective To investigate the experience in treatment of major vascular injury limbs.Methods Took active 36 cases patients with limbs.Repaired angioplasty 7 cases,end-to-end anastomosis 14 cases,autogenous vein graft 8 cases,free flaps 4 according to different conditions,and then handled associated injuries respectively.Results There were no death cases,although underwent amputation.The blood vessels repaired 33 cases,30 successful(90.9％).According assessment,limb function was good 27...
Objective To investigate the roles of insulin-like growth factor-1 (IGF-1) in rabbits fracture healing.Methods Sixty adult female New Zealand white were randomly divided into six groups according to random number method (n =10 each):normal control group (N),osteoporosis (O),and four experiment (A,B,C,D).Except for normal group,the rats rest five fed 12 weeks after removal both ovaries,resulting osteoporosis model.The left tibia model was made on all rabbits,and from first day surgery,0.2...
Objective To investigate the effect of estrogen on interleukin 6 (IL-6) bone marrow cells and marrow-derived osteoclast formation.Methods Ninety 4-month-old female SD rats were randomly divided into three groups:sham operation group (N group),ovariectomized (OVX group) + E2 group).Bone tissues cultured each after treating 1,3,5 weeks.The levels IL-6 in serum tissue culture fluid tested,and bone-derived osteoclasts numbered.Results (1) OVX respectively (62.01 ± 12.38),(95.63 16.79),(139.00...
Objective To investigate the effect of KM91104 on osteoclast differentiation and bone absorption mechanism. Methods Bone marrow mononuclear macrophage in vitro was cultured, effects (0-40 μmol/L) progenitor cell proliferation, osteoclasts, specific gene expression were observed, molecular mechanism function investigated by Western bloting. Results After treatment 0, 1.25, 2.50, 5.00 μmol/L KM91104, counts respectively 116.67±9.713, 79.67±16.166, 62.33±21.825, 27.33±13.650...