A5002749958- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related gene regulation
- Toxoplasma gondii Research Studies
- Epigenetics and DNA Methylation
- Cardiac Ischemia and Reperfusion
- Skin Protection and Aging
- Wnt/β-catenin signaling in development and cancer
- Mycobacterium research and diagnosis
- Cancer Genomics and Diagnostics
- Hearing, Cochlea, Tinnitus, Genetics
- Glioma Diagnosis and Treatment
- Identification and Quantification in Food
- Frequency Control in Power Systems
- Gout, Hyperuricemia, Uric Acid
- Salmonella and Campylobacter epidemiology
- Milk Quality and Mastitis in Dairy Cows
- Cancer, Stress, Anesthesia, and Immune Response
Harbin Medical University
2019-2025
Nankai University
2025
Sun Yat-sen Memorial Hospital
2023
Sun Yat-sen University
2023
Key Laboratory of Guangdong Province
2023
Hebei Medical University
2022-2023
Second Hospital of Hebei Medical University
2022-2023
Nanchang University
2010-2022
Second Affiliated Hospital of Nanchang University
2017-2022
Nanjing Drum Tower Hospital
2021-2022
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Cardiac hypertrophy is a precursor to heart failure and represents significant global cause of mortality, thereby necessitating timely effective therapeutic interventions. Zinc finger protein 36 (Zfp36) recognised as critical regulator ferroptosis; however, its role underlying mechanisms in cardiac remain largely unexplored. This study aims investigate the regulatory function Zfp36 ferroptosis within context hypertrophy. Single-cell sequencing analysis demonstrated reduction expression...
Heart failure (HF) is a major cause of morbidity and mortality in patients with various cardiovascular diseases. Restoration cardiac function critical improving the clinical outcomes HF. Long noncoding RNAs are widely involved development multiple diseases, whereas their role regulating remains unclear. In this study, we found that expression long RNA-DACH1 (dachshund homolog 1) was upregulated failing hearts mice human. We tested hypothesis intronic RNA DACH1 (LncDACH1) can participate...
Emerging evidence has suggested that circular RNAs (circRNAs) are involved in multiple physiological processes and participate a variety of human diseases. However, the underlying biological function circRNAs pulmonary hypertension (PH) is still ambiguous. Herein, we investigated implication regulatory effect typical circRNA, CDR1as, pathological process vascular calcification PH. Human artery smooth muscle cell (HPASMC) was analyzed by western blotting, immunofluorescence, alizarin red S...
Pathological cardiac hypertrophy (CH) is a key factor leading to heart failure and ultimately sudden death. Long non-coding RNAs (lncRNAs) are emerging as new player in gene regulation relevant wide spectrum of human disease including disorders. Here, we characterize the role specific lncRNA named hypertrophy-associated regulator (CHAR) CH delineate underlying signalling pathway. CHAR was found markedly down-regulated both vivo mouse model induced by pressure overload vitro cellular...
Background: long noncoding RNA (lncRNA) has been widely studied and understood in various cancer types. However, the expression profiles of glycolysis-related lncRNA endometrial (EC) have poorly reported. Methods: In this study, we retrieved Glycolysis gene list from Molecular Signatures Database (MSigDB) screened prognostic using The Cancer Genome Atlas (TCGA) Uterine Corpus Endometrial Carcinoma (UCEC) RNA-seq dataset. Then, TCGA UCEC patients were randomly divided. Lasso algorithm...
Pulmonary hypertension (PH) is a clinically common malignant cardiovascular disease. Pyroptosis new form of inflammatory cell death that involved in many disease processes. Glioma-associated oncogene family zinc finger 1 (GLI1) transcriptional activator participates diseases, but its role has never been explored inducing pyroptosis and the progress PH. In this study, we used an animal model molecular biology to determine effect GLI1 on chronic hypoxia-mediated PH progression pulmonary artery...
Pulmonary artery smooth muscle cells (PASMCs) proliferation caused by hypoxia is an important pathological process of pulmonary hypertension (PH). Prevention PASMCs can effectively reduce PH mortality. Long non-coding RNAs (lncRNAs) are involved in the process. Recent evidence has demonstrated that functional peptides encoded lncRNAs play roles cell pathophysiological Our previous study lnc-Rps4l with high coding ability mediates under hypoxic conditions. We hypothesize this a...
The effects of quantum dots (QDs) on the elimination nonspecific amplification polymerase chain reaction (PCR) were investigated. It was found that QDs could increase specificity PCR at different annealing temperatures and with DNA templates lengths. efficiency also studied, results showed there no enhancement. mechanisms underlying these are discussed. This method be used to modify conventional PCR. Furthermore, this technology make more widely applicable, especially in multi-PCR system...
Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, previously involved in regulation stress. In this study, we detected protective property PF against function PLIN2 vivo vitro. We found that pre-treatment could prominently alleviate cytotoxicity human...
Pulmonary hypertension is a rare, progressive disorder that can lead to right ventricular hypertrophy, heart failure, and even sudden death. N6-methyladenosine modification the main methyltransferase mediates it, methyltransferase-like (METTL) 3, exert important effects on many biological pathophysiological processes. However, role of METTL3 in pyroptosis remains unclear.
Abstract Background The therapeutic effects of conventional treatment on gliomas are not promising. tumor microenvironment (TME) has a close association with the invasiveness multiple types tumors, including low‐grade (LGG). This study aims to validate prognostic and immune‐related role macrophage scavenger receptor 1 ( MSR1 ) in LGG patients. Methods Data this were obtained from public databases. differential expression was analyzed patients different clinicopathological characteristics....
Background Cardiotrophin-like cytokine factor 1 (CLCF1) has been described as an oncogene and a potential therapeutic target in variety of cancers, but its role glioma remains unknown. Methods Based on The Cancer Genome Atlas (TCGA), we conducted bioinformatics analysis to investigate the clinical significance biological functions CLCF1 at transcriptional level predicted response immunotherapy patients with different expression levels. All results were further verified Chinese Glioma...
A single base changes causing a change to the amino acid sequence of encoded protein, which is defined as non-synonymous nucleotide polymorphisms (nsSNPs). Many nsSNPs can cause disease, and these are considered pathogenic mutations. In study, high-risk WFS1 their influence on structure function wolframin protein were predicted by multiple bioinformatics software. We obtained 13 WFS1. All highly conserved residues with conservative score 9 or 8 mostly may decrease in stability. The have an...