A5102886871- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Microstructure and Mechanical Properties of Steels
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Metal Alloys Wear and Properties
- 3D Printing in Biomedical Research
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Metallurgy and Material Forming
- Lung Cancer Treatments and Mutations
- Plant Genetic and Mutation Studies
- Epigenetics and DNA Methylation
- Polysaccharides Composition and Applications
- Endoplasmic Reticulum Stress and Disease
- Plant-based Medicinal Research
- Nuclear Structure and Function
- Bone Tissue Engineering Materials
- Immune cells in cancer
- Analytical Chemistry and Chromatography
- Fatigue and fracture mechanics
- Cell Image Analysis Techniques
- Sulfur Compounds in Biology
- Epilepsy research and treatment
City University of Macau
2025
Institute of Remote Sensing and Digital Earth
2020-2024
Southwest University of Science and Technology
2007-2024
Nanchang University
2021-2024
Guangzhou Maritime College
2023-2024
Yanshan University
2022-2024
South China Normal University
2023
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2022
Second Affiliated Hospital of Nanchang University
2021
Hunan Cancer Hospital
2019-2020
Background Protein disulfide isomerase A3 (PDIA3) is a member of the protein (PDI) family that participates in folding through its function. It has been reported to regulate progression several cancers, but function cancer immunotherapy unknown. Methods The RNA-seq data and normal tissues were downloaded from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Cbioportal dataset was used explore genomic alteration information PDIA3 pan-cancer. Human (HPA) ComPPI websites...
Attributable to sulfur's significant theoretical energy density, its affordability, and environmentally friendly nature, lithium–sulfur batteries (LSBs) are recognized as advanced storage technologies with considerable potential. Nonetheless, the solubility migration of polysulfides within electrolyte substantially hinder their practical implementation. To address this issue, we developed a nitrogen-doped two-dimensional (2D) wavy carbon nanosheet material (NCN) by using Pickering emulsion...
The antioxidant effect of 95% ethanol extract and its three subfractions, PE (petroleum ether), EtOAc (ethyl acetate), water extracts, from Gannanzao navel orange peel, were evaluated by ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)), DPPH (1,1-diphenyl-2-picryl-hydrazyl) FRAP (ferric reducing/antioxidant potential) methods for the first time. Furthermore, TPC (total polyphenol content), TFC flavonoid primary individual flavonoids four extracts analyzed compared. results...
Abstract Glioblastoma is the most frequently diagnosed primary malignant brain tumor with unfavourable prognosis and high mortality. One of its key features extensive abnormal vascular network. Up to now, mechanism angiogenesis origin vascularization remain controversial. It essential establish an ideal preclinical model elucidate vascularization, role cells in this process. In study, both U118 cell GSC23 exhibited good printability proliferation. Compared 3D‐U118, 3D‐GSC23 had a greater...
Background: This study aims to design a 3D printed handheld electrospinning device and evaluate its effect on the rapid repair of mouse skin wounds. Methods: The was developed by Solidworks Object 350 photosensitive resin printer. polylactic acid (PLA)/gelatin blend used as raw material fabricate in-situ degradable nanofiber scaffolds. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), water vapor permeability test were properties...
The pathogenic cascade of Alzheimer's disease (AD) characterized by amyloid-β protein accumulation is still poorly understood, partially owing to the limitations relevant models without in vivo neural tissue microenvironment recapitulate cell-cell interactions. To better mimic microenvironment, three-dimensional (3D) core-shell AD model constructs containing human progenitor cells (NSCs) with 2% matrigel as core bioink and alginate shell have been bioprinted a co-axial bioprinter, suitable...
Abstract Introduction Increasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in endoplasmic reticulum stress (ERS) response. However, role PDIA4 regulating glioblastoma (GBM)-specific pro-angiogenesis is still unknown. Methods The expression and prognostic were analyzed using a bioinformatics approach validated 32 clinical samples follow-up data. RNA-sequencing was used to search for PDIA4-associated biological processes GBM cells, proteomic mass spectrum...
Background Cardiotrophin-like cytokine factor 1 (CLCF1) has been described as an oncogene and a potential therapeutic target in variety of cancers, but its role glioma remains unknown. Methods Based on The Cancer Genome Atlas (TCGA), we conducted bioinformatics analysis to investigate the clinical significance biological functions CLCF1 at transcriptional level predicted response immunotherapy patients with different expression levels. All results were further verified Chinese Glioma...
Sperm autoantigen protein 17 (SPA17) is a highly conserved mammalian that participates in the acrosome reaction during fertilization and recently reported member of cancer-testicular antigen (CTA) family. It has been SPA17 expression limited adult somatic tissues re-expressed tumor tissues. Recently, studies have found regulates progression various cancers, but its role cancer immunotherapy not clear. The pan-cancer normal tissue transcriptional data were acquired from Cancer Genome Atlas...
Abstract Background: The role of DnaJ heat shock protein family (Hsp40) member C10 (DNAJC10) in cancers has been reported but its function glioma is not clear. We reveal the prognostic and underlying functions DNAJC10 present study. Methods: Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) was used to quantify relative messenger RNA (mRNA) expression clinical samples. Protein expressions samples were tested by Western blot. overall survival (OS) patients with different...
Glioma is a common intracranial malignancy in adults and has high mortality due to its poor prognosis recurrence rate. Dysregulation of protein degradation one the main promoting factors glioma development. As an indispensable unit proteasome, Proteasome 20S Subunit Beta 9 (PSMB9) major enzymes ubiquitin-dependent cells. In addition, proteasomes also participate series cellular processing, like immune regulation, nerve signal transduction, material transport through channels, cell adhesion,...
Controlling continuous cooling is an important means to control the most mechanical properties of bainitic steel for frogs in railroad applications. In this paper, a railway taken as research object. By designing different rates transformation medium temperature region, effect rate on fatigue crack propagation was studied. The results show sample 4 °C/s exhibits higher strength and impact toughness, while near threshold significantly lower relatively at 0.1 rate. This related fact that more...
Abstract Aims This real‐world study is conducted to evaluate the efficacy and safety of recombinant human endostatin (rh‐endostatin) combined with chemotherapy as first‐line treatment for non‐driver genes mutation non‐small cell lung cancer (NSCLC) patients, establish evidence‐based optimal regimen rh‐endostatin. Patients Methods Using propensity score matching (cut‐off: 0.01), 88 patients were eligible our study, 34 which received platinum‐based alone (chemotherapy group), 54 plus...
An accumulation of studies has indicated aging to be a significant hazard factor for the development tumors. Cellular senescence is positively associated with progress and aging-related genes (AGs) can regulate cellular tumor malignancy. While association between AGs prognosis patients glioma still unclear. In our study, we initially selected four survival-associated performed consensus clustering these based on The Cancer Genome Atlas (TCGA) database. We then explored potential biological...
Glioblastomas are the most frequently diagnosed and one of lethal primary brain tumors, their key features is a dysplastic vascular network. However, because origin tumor blood vessels remains controversial, an optimal preclinical model must be established to elucidate angiogenesis mechanism, especially role cells themselves in angiogenesis. Therefore, shell-glioma cell (U118)-red fluorescent protein (RFP)/core-human umbilical vein endothelial (HUVEC)-green (GFP) hydrogel microfibers were...
The first hyperpolarizabilities, β HRS , of corrole derivatives have been measured by using Hyper–Rayleigh Scattering technique. results showed that corroles could be greatly enhanced modifying its periphery with donor–acceptor groups. Maximum value reaches 354 × 10 -30 esu at an incident wavelength 1500 nm. investigated were also calculated the Zerner's intermediate neglect differential overlap/configuration interaction/sum-over-states method. and experimental are in good agreement conclude...
Many studies have defined a critical role for ferroptosis in cancer progression and therapy, but it is unclear how regulates tumor immunity or microenvironment (TME). In this study, 24 ferroptosis-regulators were assessed by nonnegative matrix factorization (NMF) consensus clustering to identify patterns lower-grade gliomas (LGGs). Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method single sample gene set enrichment analysis (ssGSEA) used quantify...
Abstract Background The p21-activated kinase (PAK) family (PAKs) plays a key role in the formation and development of human tumors. However, systematic analysis PAKs cancers is lacking potential cancer immunity has not been explored. Methods We used datasets from Cancer Genome Atlas (TCGA) database Genotype-Tissue Expression (GTEx). Results Based on TCGA most show noteworthy differences expression between tumors corresponding normal tissues or across different tumor tissues. Patients with...
Chondroitin polymerizing factor (CHPF) is an important glycosyltransferases that participates in the biosynthesis of chondroitin sulfate (CS). Our previous study showed silencing CHPF expression inhibited glioma cell proliferation vitro, but molecular mechanisms by which contributes to development have not been characterized. In this study, we found was up-regulated tissues and positively correlated with malignant clinical pathological characteristics patients glioma. Silencing...