A5037953219- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Pancreatic function and diabetes
- Protein Degradation and Inhibitors
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
Qinghai Provincial Peoples Hospital
2015-2025
Huazhong University of Science and Technology
2020-2024
Tongji Hospital
2021-2024
Louisiana State University Health Sciences Center Shreveport
2018-2024
First Affiliated Hospital of Henan University
2024
National Clinical Research Center for Digestive Diseases
2021-2024
Peking University Shenzhen Hospital
2022
Shandong Center for Disease Control and Prevention
2020
Nanjing Drum Tower Hospital
2018
Qinghai University
2016-2017
Ferroptosis is a type of cell death driven by iron accumulation and lipid peroxidation, which involved in the pathogenesis various tumors. Small ubiquitin-like modifier (SUMO)-specific protease 1 (SENP1) critical SUMO-specific protease, controls multiple cellular signaling processes. However, roles mechanisms SENP1-mediated protein SUMOylation regulation ferroptosis remain unexplored.The gene expression SENP1 ferroptosis-related genes samples lung cancer patient cells were determined...
Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon binding partners, ikaros aiolos, induce many cellular responses, including cytotoxicity to multiple myeloma (MM) cells. Nevertheless, it takes days for MM cells die after IMiD induced depletion aiolos thus we searched other partners participate in cytotoxicity. Cereblon were...
Abstract Background The T helper 17 (Th17)/T regulatory (Treg) cell imbalance is involved in the course of obesity and type 2 diabetes mellitus (T2DM). In current study, exact role glucagon-like peptide-1 receptor agonist (GLP-1RA) exenatide on regulating Th17/Treg balance underlying molecular mechanisms are investigated obese diabetic mice model. Methods Metabolic parameters were monitored db/db treated with/without during 8-week study period. frequencies Th17 Treg cells from peripheral...
Immune checkpoint inhibitors (ICI)-based combination strategies have improved the survival outcomes in advanced non-small cell lung cancers; however, data regarding their efficacy remains limited for uncommon histological types, including large-cell carcinoma (LCC) and neuroendocrine (LCNEC).We retrospectively analyzed a total of 60 patients with LCC LCNEC - 37 treatment-naïve 23 pre-treated who received pembrolizumab or without chemotherapy. Treatment were analyzed.Of first-line combined...
Abstract Background Pembrolizumab has been indicated in the treatment of solid tumors with high frequency microsatellite instability (MSI-H) or tumor mutational burden (TMB-H); however, real-world data on effectiveness pembrolizumab without chemotherapy this molecular subset remain limited. Our retrospective study evaluated clinical efficacy and safety treating advanced either MSI-H TMB-H. Methods This analyzed from 116 patients TMB-H cancers who received regardless setting. We objective...
To the Editor: Lung cancer is characterized by its high incidence and mortality rates, imposing a significant burden of disease globally.[1] Liver metastasis associated with poorer clinical outcomes shorter life expectancy in non-small cell lung (NSCLC).[2] Although immune checkpoint inhibitors (ICIs) have revolutionized treatment NSCLC, existing predictive prognostic biomarkers limited effectiveness pose challenge, particularly for patients liver metastasis. The albumin–bilirubin (ALBI)...
ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect efficacy in are not yet well-elucidated. Our retrospective study aimed to compare the of chemotherapy treatment advanced cancer evaluate various might impact real-world practice.Treatment responses, survival outcomes, patterns disease progression were analyzed for 235 patients with locally who received (n = 67) or 168).The overall response rate was 85.7%...
// Long-Xian Lv 1, 2, * , Zhen-Xing Zhou Zhan 1 Li-Jiang Zhang Ren Yan 2 Zhao Li-Ya Yang Xiao-Yuan Bian Hui-Yong Jiang Yu-Dong Li Yi-Sheng Sun Qin-Qin Xu Gui-Li Hu 3 Wen-Jun Guan Yong-Quan Institute of Pharmaceutical Biotechnology and College Sciences, Zhejiang University, 310058 Hangzhou, China State Key Laboratory for Diagnosis Treatment Infectious Diseases, Collaborative Innovation Center The First Affiliated Hospital, Medicine, 310003 Department Basic These authors contributed equally to...
The programmed death-ligand 1 (PD-L1) 22C3 assay is one of the approved companion diagnostic assays for receiving anti-programmed cell death ligand therapy. Our study evaluated performance E1L3N and antibodies in estimating PD-L1 expression non-small lung cancer (NSCLC).Our retrospective included 46 patients diagnosed with unresectable EGFR/ALK/ROS1-negative NSCLC who received first-line pembrolizumab therapy between 2018 2021. immunohistochemistry baseline tissue biopsy samples was...
Anaplastic thyroid carcinoma (ATC) is almost universally fatal. Elevated keratin-8 (KRT8) protein expression an established diagnostic cancer biomarker in several epithelial cancers (but not ATC). Several keratins, including KRT8, have been suggested to a role cell biology beyond that of structural cytoskeletal proteins. Here, we provide evidence KRT8 plays direct the growth ATCs. Genomic and transcriptomic analysis >5000 patients demonstrates mutation copy number amplification are...