A5024910931- Reproductive Biology and Fertility
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Nanoplatforms for cancer theranostics
- Renal and related cancers
- Immune cells in cancer
- Genetics, Aging, and Longevity in Model Organisms
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Nanoparticle-Based Drug Delivery
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Minimally Invasive Surgical Techniques
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Carbon and Quantum Dots Applications
- Genetic Associations and Epidemiology
- Redox biology and oxidative stress
- Animal Genetics and Reproduction
- Sirtuins and Resveratrol in Medicine
- Optimism, Hope, and Well-being
Zhongnan Hospital of Wuhan University
2021-2025
Wuhan University
2021-2025
Hubei University of Technology
2023
East China Jiaotong University
2023
Huazhong University of Science and Technology
2013-2021
Tongji Hospital
2013-2021
Central Hospital of Wuhan
2019
Army Medical University
2009
Cell-membrane-coated nanoparticles are widely studied due to their inherent cellular properties, such as immune escape and homologous homing. A cell membrane coating can also maintain the relative stability of during circulation in a complex blood environment through encapsulation technology. In this study, we fused murine-derived ID8 ovarian cancer with red (RBC) create hybrid biomimetic (IRM), IRM camouflaged indocyanine green (ICG)-loaded magnetic (Fe
Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their...
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed system remain elusive. Recent advancements omics technologies computational capabilities facilitated emergence multiomics deep phenotyping. Through application refinement various high-throughput methods, a...
Ovarian aging is a long-term and complex process associated with decrease in follicular quantity quality. The damaging effects of reactive oxygen species (ROS) ovarian aging-associated disorders have received relatively little attention. Thus, we assessed if the oxidative stress induced by (defined Environmental Protection Agency as at least 30 days duration) moderate ozone inhalation reduced reserves, decreased function disorders. expression markers antioxidant enzymes was used to determine...
Ferroptosis is characterized by iron accumulation and lipid peroxidation. However, a clinical dose of Fe3O4 nanoparticles could not cause effective ferroptosis in tumors, the mechanism yet to be completely understood. In this study, using RNA-seq data, we found that tumor cells feedback-activate antioxidant system upregulating Nrf-2 expression, thus avoiding caused nanoparticles. We also DHJS (a probe for ROS generation) can antagonize expression when it synergizes with nanoparticles,...
Aggresomes are the product of misfolded protein aggregation, and presence aggresomes has been correlated with poor prognosis in cancer patients. However, exact role tumorigenesis progression remains largely unknown. Herein, multiomics screening reveal that OTUD1 plays an important retaining ovarian stem cell (OCSC) properties. Mechanistically, elevated levels lead to formation OTUD1-based cytoplasmic aggresomes, which is mediated by a short peptide located intrinsically disordered N-terminal...
Hemicyanine molecules have unparalleled potential in the fields of fluorescence sensing, bioimaging, and disease therapeutics due to their excellent optical properties, cell penetration, mitochondrial targeting, photosensitivity. Herein, three dual-cation hemicyanine molecular probes named DCy, PDCy, TDCy were developed. All them could detect HSO3-, PDCy recognize HSO3- under 365 nm ultraviolet light or sunlight. In addition, is a multifunctional molecule, which has following advantages:...
Abstract CpG oligodeoxynucleotides (CpG), as an immunoadjuvant, can facilitate the transformation of tumor‐associated macrophages (TAMs)into tumoricidal M1 macrophages. However, accumulation free in tumor tissues remains a substantial challenge. To address this, nanovaccine (PLGA‐CpG@ID8‐M) is engineered by encapsulating within PLGA using ID8 ovarian cancer cell membranes (ID8‐M). This demonstrates remarkable efficacy reprogramming TAMs and significantly extends survival ID8‐bearing mice....
Chiral nanomaterials have great potential in improving the clinical therapeutic effect due to unique chiral selectivity of biosystems. However, such a promising strategy has so far received little attention cancer treatment. Here, we report first Fenton catalyst, d-/l-penicillamine-modified Cu2-xSe nanoparticles (d-/l-NPs), for enhanced synergistic chemodynamic therapy (CDT) and photothermal (PTT) under second near-infrared (NIR-II) light irradiation. The study NPs on cells shows that d-NPs...
Stimuli-responsive hydrogel actuators have attracted tremendous interest in switches and microrobots. Based on N-isopropylacrylamide (NIPAM) monomers with LCST phase separation photochromic molecule spiropyran which can respond to ultraviolet light H+, we develop a novel multistimuli-responsive co-polymer anisotropic bilayer hydrogel, undergo complex deformation behavior under environmental stimuli. Diverse bending angles were achieved based inhomogeneous swelling. By controlling the...
Early menopause and infertility often occur in female cancer patients after chemotherapy (CTx). For these patients, oocyte/embryo cryopreservation or ovarian tissue is the current modality for fertility preservation. However, above methods are limited long-term protection of function, especially preservation (very few females with have achieved pregnancy cryopreserved eggs until now). In addition, subject to their scope (females no husband prepubertal mature oocytes). Thus, many who suffer...
Sonochemistry-assisted photocontrolled atom transfer radical polymerization (SAP-ATRP) is developed to circumvent the problem caused by low penetration depth of light.
Female germline stem cells (FGSCs) or oogonial (OSCs) have the capacity to generate newborn oocytes and thus open a new door fight ovarian aging female infertility. However, production identification of OSCs are difficult for investigators. Rare amount these in ovary results failure acquisition OSCs. Furthermore, oocyte formation by vivo was usually confirmed using tissue sections immunofluorescence immunohistochemistry previous studies. STO MEF feeder derived from mouse, not human. In our...