A5103004793- Genetics, Aging, and Longevity in Model Organisms
- Cell death mechanisms and regulation
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Single-cell and spatial transcriptomics
- Hemophilia Treatment and Research
- Reproductive Biology and Fertility
- Chronic Myeloid Leukemia Treatments
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Machine Learning in Bioinformatics
Second Military Medical University
2024
Shanghai Pudong New Area Gongli Hospital
2024
Chinese PLA General Hospital
2023
Duke Medical Center
1998
Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their...
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vascular dysplasia and recurrent hemorrhage. One of the causative genes activin receptor-like kinase-1 (ALK-1) gene located on chromosome 12q13. ALK-1 endothelial cell type I receptor for TGF-β superfamily ligands. As a number mutations have been identified in kinase domain ALK-1, we initiated mutation analysis specifically targeting first four coding exons order to determine if...
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